Transient deficiency of protein S after past infection process, complications and outcome: clinical case
Background. Purpura fulminans (PF) – is an acute rapidly progressive thrombosis of small-diameter blood vessels located mainly on the skin of the extremities. PF is characterized by high mortality rates. Patients can have serious consequences, including amputations and loss of fingers, foots or even...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Union of pediatricians of Russia
2023-03-01
|
| Series: | Педиатрическая фармакология |
| Subjects: | |
| Online Access: | https://www.pedpharma.ru/jour/article/view/2270 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850047596274384896 |
|---|---|
| author | Olga B. Gordeeva Albina V. Dobrotok Liliia R. Selimzianova Valeria A. Deeva |
| author_facet | Olga B. Gordeeva Albina V. Dobrotok Liliia R. Selimzianova Valeria A. Deeva |
| author_sort | Olga B. Gordeeva |
| collection | DOAJ |
| description | Background. Purpura fulminans (PF) – is an acute rapidly progressive thrombosis of small-diameter blood vessels located mainly on the skin of the extremities. PF is characterized by high mortality rates. Patients can have serious consequences, including amputations and loss of fingers, foots or even extremities in general.Clinical case description. A clinical case of developing transient deficiency of protein S complicated by idiopathic PF on the 7th day after acute otitis in a 3-year-old boy due to past infection is presented. The progression of the disease developed within a few hours. The patient became hemorrhagic elements on the skin of extremities, and later — tissue necrosis. The conducted therapy facilitated to stop the pathological process in the form of PF, and also prevented the development of severe disabling complications in the child.Conclusion. Differential diagnosis and treatment should be fast and accurate, as the development of PF occurs in mere hours. Diagnostics should include expanded panel of coagulological tests and instrumental examinations, which determines the justifiability of a multidisciplinary approach in the patient management with disorders in the hemostatic system. |
| format | Article |
| id | doaj-art-c11f6a50ea944e1caea57df117f79277 |
| institution | DOAJ |
| issn | 1727-5776 2500-3089 |
| language | Russian |
| publishDate | 2023-03-01 |
| publisher | Union of pediatricians of Russia |
| record_format | Article |
| series | Педиатрическая фармакология |
| spelling | doaj-art-c11f6a50ea944e1caea57df117f792772025-08-20T02:54:11ZrusUnion of pediatricians of RussiaПедиатрическая фармакология1727-57762500-30892023-03-01201697610.15690/pf.v20i1.25321961Transient deficiency of protein S after past infection process, complications and outcome: clinical caseOlga B. Gordeeva0Albina V. Dobrotok1Liliia R. Selimzianova2Valeria A. Deeva3Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of SurgeryResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University; Sechenov First Moscow State Medical UniversityPirogov Russian National Research Medical UniversityBackground. Purpura fulminans (PF) – is an acute rapidly progressive thrombosis of small-diameter blood vessels located mainly on the skin of the extremities. PF is characterized by high mortality rates. Patients can have serious consequences, including amputations and loss of fingers, foots or even extremities in general.Clinical case description. A clinical case of developing transient deficiency of protein S complicated by idiopathic PF on the 7th day after acute otitis in a 3-year-old boy due to past infection is presented. The progression of the disease developed within a few hours. The patient became hemorrhagic elements on the skin of extremities, and later — tissue necrosis. The conducted therapy facilitated to stop the pathological process in the form of PF, and also prevented the development of severe disabling complications in the child.Conclusion. Differential diagnosis and treatment should be fast and accurate, as the development of PF occurs in mere hours. Diagnostics should include expanded panel of coagulological tests and instrumental examinations, which determines the justifiability of a multidisciplinary approach in the patient management with disorders in the hemostatic system.https://www.pedpharma.ru/jour/article/view/2270purpura fulminanshemostasisdic syndromedeficiency of protein sclinical case |
| spellingShingle | Olga B. Gordeeva Albina V. Dobrotok Liliia R. Selimzianova Valeria A. Deeva Transient deficiency of protein S after past infection process, complications and outcome: clinical case Педиатрическая фармакология purpura fulminans hemostasis dic syndrome deficiency of protein s clinical case |
| title | Transient deficiency of protein S after past infection process, complications and outcome: clinical case |
| title_full | Transient deficiency of protein S after past infection process, complications and outcome: clinical case |
| title_fullStr | Transient deficiency of protein S after past infection process, complications and outcome: clinical case |
| title_full_unstemmed | Transient deficiency of protein S after past infection process, complications and outcome: clinical case |
| title_short | Transient deficiency of protein S after past infection process, complications and outcome: clinical case |
| title_sort | transient deficiency of protein s after past infection process complications and outcome clinical case |
| topic | purpura fulminans hemostasis dic syndrome deficiency of protein s clinical case |
| url | https://www.pedpharma.ru/jour/article/view/2270 |
| work_keys_str_mv | AT olgabgordeeva transientdeficiencyofproteinsafterpastinfectionprocesscomplicationsandoutcomeclinicalcase AT albinavdobrotok transientdeficiencyofproteinsafterpastinfectionprocesscomplicationsandoutcomeclinicalcase AT liliiarselimzianova transientdeficiencyofproteinsafterpastinfectionprocesscomplicationsandoutcomeclinicalcase AT valeriaadeeva transientdeficiencyofproteinsafterpastinfectionprocesscomplicationsandoutcomeclinicalcase |