ImputeHiFI: An Imputation Method for Multiplexed DNA FISH Data by Utilizing Single‐Cell Hi‐C and RNA FISH Data

ImputeHiFI: An Imputation Method for Multiplexed DNA FISH Data by Utilizing Single‐Cell Hi‐C and RNA FISH Data

Abstract Although multiplexed DNA fluorescence in situ hybridization (FISH) enables tracking the spatial localization of thousands of genomic loci using probes within individual cells, the high rates of undetected probes impede the depiction of 3D chromosome structures. Current data imputation metho...

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Bibliographic Details
Main Authors: Shichen Fan, Dachang Dang, Lin Gao, Shihua Zhang
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Advanced Science
Subjects:
3D genomes
single‐cell Hi‐C data
DNA FISH data
multimodal imaging
imputation
Online Access:https://doi.org/10.1002/advs.202406364
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