AR and YAP crosstalk: impacts on therapeutic strategies in prostate cancer
Prostate cancer ranks as one of the most common types of cancer affecting men worldwide, and its progression is shaped by a diverse array of influencing factors. The AR signaling pathway plays a pivotal role in the pathogenesis of prostate cancer. While existing anti-androgen treatments show initial...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1520808/full |
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| author | Guansong Zheng Zhaojie Yan Junrong Zou Junrong Zou Junrong Zou Xiaofeng Zou Keqiang Chai Guoxi Zhang |
| author_facet | Guansong Zheng Zhaojie Yan Junrong Zou Junrong Zou Junrong Zou Xiaofeng Zou Keqiang Chai Guoxi Zhang |
| author_sort | Guansong Zheng |
| collection | DOAJ |
| description | Prostate cancer ranks as one of the most common types of cancer affecting men worldwide, and its progression is shaped by a diverse array of influencing factors. The AR signaling pathway plays a pivotal role in the pathogenesis of prostate cancer. While existing anti-androgen treatments show initial efficacy, they ultimately do not succeed in halting the advancement to CRPC. Recent studies have identified alterations in the Hippo-YAP signaling pathway within prostate cancer, highlighting intricate crosstalk with the AR signaling pathway. In this review, we examine the interactions and underlying mechanisms between AR and YAP, the key molecules in these two signaling pathways. AR regulates the stability and function of YAP by modulating its transcription, translation, and phosphorylation status, while YAP exerts both promotional and inhibitory regulatory effects on AR. Based on these findings, this paper investigates their significant roles in the onset, progression, and therapeutic resistance of prostate cancer, and discusses the clinical potential of YAP in prostate cancer treatment. |
| format | Article |
| id | doaj-art-c10a00a50b4b4920b39f0b07096ff0b0 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-c10a00a50b4b4920b39f0b07096ff0b02025-02-03T05:12:01ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.15208081520808AR and YAP crosstalk: impacts on therapeutic strategies in prostate cancerGuansong Zheng0Zhaojie Yan1Junrong Zou2Junrong Zou3Junrong Zou4Xiaofeng Zou5Keqiang Chai6Guoxi Zhang7First Clinical College, Gannan Medical University, Ganzhou, ChinaFirst Clinical College, Gannan Medical University, Ganzhou, ChinaDepartment of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaInstitute of Urology, Gannan Medical University, Ganzhou, ChinaDepartment of Jiangxi Engineering Technology Research Center of Calculi Prevention, Gannan Medical University, Ganzhou, ChinaDepartment of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Urology, Third Affiliated Hospital of Gansu University of Chinese Medicine, Baiyin, ChinaDepartment of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaProstate cancer ranks as one of the most common types of cancer affecting men worldwide, and its progression is shaped by a diverse array of influencing factors. The AR signaling pathway plays a pivotal role in the pathogenesis of prostate cancer. While existing anti-androgen treatments show initial efficacy, they ultimately do not succeed in halting the advancement to CRPC. Recent studies have identified alterations in the Hippo-YAP signaling pathway within prostate cancer, highlighting intricate crosstalk with the AR signaling pathway. In this review, we examine the interactions and underlying mechanisms between AR and YAP, the key molecules in these two signaling pathways. AR regulates the stability and function of YAP by modulating its transcription, translation, and phosphorylation status, while YAP exerts both promotional and inhibitory regulatory effects on AR. Based on these findings, this paper investigates their significant roles in the onset, progression, and therapeutic resistance of prostate cancer, and discusses the clinical potential of YAP in prostate cancer treatment.https://www.frontiersin.org/articles/10.3389/fonc.2025.1520808/fullprostate cancerandrogen receptoryes-associated proteincrosstalkmechanism |
| spellingShingle | Guansong Zheng Zhaojie Yan Junrong Zou Junrong Zou Junrong Zou Xiaofeng Zou Keqiang Chai Guoxi Zhang AR and YAP crosstalk: impacts on therapeutic strategies in prostate cancer Frontiers in Oncology prostate cancer androgen receptor yes-associated protein crosstalk mechanism |
| title | AR and YAP crosstalk: impacts on therapeutic strategies in prostate cancer |
| title_full | AR and YAP crosstalk: impacts on therapeutic strategies in prostate cancer |
| title_fullStr | AR and YAP crosstalk: impacts on therapeutic strategies in prostate cancer |
| title_full_unstemmed | AR and YAP crosstalk: impacts on therapeutic strategies in prostate cancer |
| title_short | AR and YAP crosstalk: impacts on therapeutic strategies in prostate cancer |
| title_sort | ar and yap crosstalk impacts on therapeutic strategies in prostate cancer |
| topic | prostate cancer androgen receptor yes-associated protein crosstalk mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1520808/full |
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