The additive diagnostic value of ultrasonic strain elastography in characterizing BI-RADS 4 breast lesions
Abstract Background Breast cancer is a significant global health issue and is a leading cause of female deaths worldwide. Ultrasonography (US) is an adjunct technique for early diagnosis of breast cancer but has low specificity. So, researchers have suggested using US elastography to distinguish bet...
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SpringerOpen
2025-02-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
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| Online Access: | https://doi.org/10.1186/s43055-025-01427-y |
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| author | Dalia Bayoumi Farah Ahmed Shokeir Rasha Karam Ghada Hassan Abd Elraouf Dina Abdallah Ibrahim Aya Elboghdady |
| author_facet | Dalia Bayoumi Farah Ahmed Shokeir Rasha Karam Ghada Hassan Abd Elraouf Dina Abdallah Ibrahim Aya Elboghdady |
| author_sort | Dalia Bayoumi |
| collection | DOAJ |
| description | Abstract Background Breast cancer is a significant global health issue and is a leading cause of female deaths worldwide. Ultrasonography (US) is an adjunct technique for early diagnosis of breast cancer but has low specificity. So, researchers have suggested using US elastography to distinguish between benign and malignant breast lesions, which may lead to a decrease in unnecessary biopsy rates. We aimed to assess the diagnostic performance of strain elastography and if there was an increase in the diagnostic accuracy after adding it to conventional US results in BI-RADS 4 category breast lesions. Results This cross-sectional study was carried out from June 2022 to June 2024 on 240 patients with 240 breast lesions that were diagnosed as BI-RADS 4 category by conventional US. All the cases were examined using conventional US and strain elastography. Out of the 240 lesions, 107 were benign (44.6%) and 133 were malignant (55.4%). There was a significant statistical difference in the mean age of patients with benign breast lesions (37.89 ± 13.42 years) than those with malignant lesions (48.83 ± 13.65 years) (p < 0.001). Lesions’ imaging characteristics detected by conventional US as shape, margin, aspect ratio, vascularity, and calcification all showed significant differences between benign and malignant breast lesions (p < 0.001). The diagnostic accuracy of conventional US alone was 73.3% and increased to 95.3% after combining it with strain elastography. The strain elastography score has a cutoff value of 4 in discriminating malignant from benign lesions (AUC = 0.9). Conclusions Strain elastography provides an added diagnostic value in discriminating malignant breast lesions from benign lesions. The combination of strain elastography with US BI-RADS increases the diagnostic accuracy for the detection of malignant breast lesions which will decrease the need for unnecessary biopsy. |
| format | Article |
| id | doaj-art-c109f573b6a24adfabd39117ea6fab08 |
| institution | Kabale University |
| issn | 2090-4762 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj-art-c109f573b6a24adfabd39117ea6fab082025-02-09T12:26:30ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622025-02-0156111210.1186/s43055-025-01427-yThe additive diagnostic value of ultrasonic strain elastography in characterizing BI-RADS 4 breast lesionsDalia Bayoumi0Farah Ahmed Shokeir1Rasha Karam2Ghada Hassan Abd Elraouf3Dina Abdallah Ibrahim4Aya Elboghdady5Department of Radiology, Faculty of Medicine, Mansoura UniversityDepartment of Radiology, Faculty of Medicine, Mansoura UniversityDepartment of Radiology, Faculty of Medicine, Mansoura UniversityDepartment of Radiology, Faculty of Medicine, Mansoura UniversityDepartment of Pathology, Faculty of Medicine, Mansoura UniversityDepartment of Radiology, Faculty of Medicine, Mansoura UniversityAbstract Background Breast cancer is a significant global health issue and is a leading cause of female deaths worldwide. Ultrasonography (US) is an adjunct technique for early diagnosis of breast cancer but has low specificity. So, researchers have suggested using US elastography to distinguish between benign and malignant breast lesions, which may lead to a decrease in unnecessary biopsy rates. We aimed to assess the diagnostic performance of strain elastography and if there was an increase in the diagnostic accuracy after adding it to conventional US results in BI-RADS 4 category breast lesions. Results This cross-sectional study was carried out from June 2022 to June 2024 on 240 patients with 240 breast lesions that were diagnosed as BI-RADS 4 category by conventional US. All the cases were examined using conventional US and strain elastography. Out of the 240 lesions, 107 were benign (44.6%) and 133 were malignant (55.4%). There was a significant statistical difference in the mean age of patients with benign breast lesions (37.89 ± 13.42 years) than those with malignant lesions (48.83 ± 13.65 years) (p < 0.001). Lesions’ imaging characteristics detected by conventional US as shape, margin, aspect ratio, vascularity, and calcification all showed significant differences between benign and malignant breast lesions (p < 0.001). The diagnostic accuracy of conventional US alone was 73.3% and increased to 95.3% after combining it with strain elastography. The strain elastography score has a cutoff value of 4 in discriminating malignant from benign lesions (AUC = 0.9). Conclusions Strain elastography provides an added diagnostic value in discriminating malignant breast lesions from benign lesions. The combination of strain elastography with US BI-RADS increases the diagnostic accuracy for the detection of malignant breast lesions which will decrease the need for unnecessary biopsy.https://doi.org/10.1186/s43055-025-01427-yBreast cancerBI-RADS 4 category breast lesionsConventional USStrain elastographyStrain elastography ratioStrain elastography score |
| spellingShingle | Dalia Bayoumi Farah Ahmed Shokeir Rasha Karam Ghada Hassan Abd Elraouf Dina Abdallah Ibrahim Aya Elboghdady The additive diagnostic value of ultrasonic strain elastography in characterizing BI-RADS 4 breast lesions The Egyptian Journal of Radiology and Nuclear Medicine Breast cancer BI-RADS 4 category breast lesions Conventional US Strain elastography Strain elastography ratio Strain elastography score |
| title | The additive diagnostic value of ultrasonic strain elastography in characterizing BI-RADS 4 breast lesions |
| title_full | The additive diagnostic value of ultrasonic strain elastography in characterizing BI-RADS 4 breast lesions |
| title_fullStr | The additive diagnostic value of ultrasonic strain elastography in characterizing BI-RADS 4 breast lesions |
| title_full_unstemmed | The additive diagnostic value of ultrasonic strain elastography in characterizing BI-RADS 4 breast lesions |
| title_short | The additive diagnostic value of ultrasonic strain elastography in characterizing BI-RADS 4 breast lesions |
| title_sort | additive diagnostic value of ultrasonic strain elastography in characterizing bi rads 4 breast lesions |
| topic | Breast cancer BI-RADS 4 category breast lesions Conventional US Strain elastography Strain elastography ratio Strain elastography score |
| url | https://doi.org/10.1186/s43055-025-01427-y |
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