JCV-specific cell-based assays for PML risk assessment in lupus and multiple sclerosis patients with and without natalizumab

JCV-specific cell-based assays for PML risk assessment in lupus and multiple sclerosis patients with and without natalizumab

BackgroundProgressive multifocal leukoencephalopathy (PML) is an opportunistic infection caused by the JC virus and often fatal. Natalizumab is a highly effective therapy for multiple sclerosis (MS) but is linked to a high incidence of PML. The current metrics used to stratify MS patients at risk fo...

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Bibliographic Details
Main Authors: Qi Wu, Elizabeth A. Mills, Qin Wang, Guangmei Mao, Yang Mao-Draayer
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Neurology
Subjects:
PML
DMT
MS
cytotoxicity index
OX40 immunity index
natalizumab (Tysabri)
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2025.1584083/full
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