Antibodies against SARS-CoV-2 in unvaccinated children hospitalized with COVID-19: An observational cohort study of pre-Omicron and Omicron variants era.
<h4>Purpose</h4>This study aimed to investigate the antibodies against SARS-CoV-2 in children hospitalized due to COVID-19 during the era of pre-Omicron and Omicron variants.<h4>Methods</h4>This was a retrospective observational study conducted at a tertiary academic medical...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2024-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0297991 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850155726817722368 |
|---|---|
| author | Rattapon Uppala Phanthila Sitthikarnkha Kiatichai Faksri Pope Kosalaraksa Leelawadee Techasatian Nattakarn Tantawarak Sysavanh Nanthavongsa |
| author_facet | Rattapon Uppala Phanthila Sitthikarnkha Kiatichai Faksri Pope Kosalaraksa Leelawadee Techasatian Nattakarn Tantawarak Sysavanh Nanthavongsa |
| author_sort | Rattapon Uppala |
| collection | DOAJ |
| description | <h4>Purpose</h4>This study aimed to investigate the antibodies against SARS-CoV-2 in children hospitalized due to COVID-19 during the era of pre-Omicron and Omicron variants.<h4>Methods</h4>This was a retrospective observational study conducted at a tertiary academic medical center in Thailand between June 2021 and August 2022. We collected the data of children aged under 18-year who were hospitalized from SARS-CoV-2 infection. After hospital discharge, we scheduled clinical follow-up 60 to 90 days post-infection clinical follow-up. We measured antibodies against SARS-CoV-2 anti-spike protein receptor-binding domain in the serum during a follow-up visit and compared the mean difference of antibody levels between children infected with COVID-19 during the pre-Omicron and Omicron eras.<h4>Results</h4>A total of 119 children enrolled into the study. There were 58 and 61 children hospitalized due to COVID-19 during pre-Omicron and Omicron era, respectively. The median (interquartile range, IQR) of SARS-CoV-2 antibodies in all cases was 206.1 (87.9-424.1) U/mL at follow-up. Children infected during pre-Omicron had SARS-CoV-2 antibody levels at follow-up higher than children infected during Omicron era [mean difference 292.57 U/mL, 95% CI 53.85-531.28, p = 0.017). There was no difference in SARS-CoV-2 antibody levels between the children based on gender, age, co-morbidities, chest radiograph classification, or diagnosis.<h4>Conclusions</h4>The antibodies response to SARS-CoV-2 infection was weaker during the Omicron era than previous variant of concern. Immunization strategies and policies should be implemented in children even if they had been previously infected. |
| format | Article |
| id | doaj-art-c104c5ba7ee0499dadac73a1b0bb7a69 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-c104c5ba7ee0499dadac73a1b0bb7a692025-08-20T02:24:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01192e029799110.1371/journal.pone.0297991Antibodies against SARS-CoV-2 in unvaccinated children hospitalized with COVID-19: An observational cohort study of pre-Omicron and Omicron variants era.Rattapon UppalaPhanthila SitthikarnkhaKiatichai FaksriPope KosalaraksaLeelawadee TechasatianNattakarn TantawarakSysavanh Nanthavongsa<h4>Purpose</h4>This study aimed to investigate the antibodies against SARS-CoV-2 in children hospitalized due to COVID-19 during the era of pre-Omicron and Omicron variants.<h4>Methods</h4>This was a retrospective observational study conducted at a tertiary academic medical center in Thailand between June 2021 and August 2022. We collected the data of children aged under 18-year who were hospitalized from SARS-CoV-2 infection. After hospital discharge, we scheduled clinical follow-up 60 to 90 days post-infection clinical follow-up. We measured antibodies against SARS-CoV-2 anti-spike protein receptor-binding domain in the serum during a follow-up visit and compared the mean difference of antibody levels between children infected with COVID-19 during the pre-Omicron and Omicron eras.<h4>Results</h4>A total of 119 children enrolled into the study. There were 58 and 61 children hospitalized due to COVID-19 during pre-Omicron and Omicron era, respectively. The median (interquartile range, IQR) of SARS-CoV-2 antibodies in all cases was 206.1 (87.9-424.1) U/mL at follow-up. Children infected during pre-Omicron had SARS-CoV-2 antibody levels at follow-up higher than children infected during Omicron era [mean difference 292.57 U/mL, 95% CI 53.85-531.28, p = 0.017). There was no difference in SARS-CoV-2 antibody levels between the children based on gender, age, co-morbidities, chest radiograph classification, or diagnosis.<h4>Conclusions</h4>The antibodies response to SARS-CoV-2 infection was weaker during the Omicron era than previous variant of concern. Immunization strategies and policies should be implemented in children even if they had been previously infected.https://doi.org/10.1371/journal.pone.0297991 |
| spellingShingle | Rattapon Uppala Phanthila Sitthikarnkha Kiatichai Faksri Pope Kosalaraksa Leelawadee Techasatian Nattakarn Tantawarak Sysavanh Nanthavongsa Antibodies against SARS-CoV-2 in unvaccinated children hospitalized with COVID-19: An observational cohort study of pre-Omicron and Omicron variants era. PLoS ONE |
| title | Antibodies against SARS-CoV-2 in unvaccinated children hospitalized with COVID-19: An observational cohort study of pre-Omicron and Omicron variants era. |
| title_full | Antibodies against SARS-CoV-2 in unvaccinated children hospitalized with COVID-19: An observational cohort study of pre-Omicron and Omicron variants era. |
| title_fullStr | Antibodies against SARS-CoV-2 in unvaccinated children hospitalized with COVID-19: An observational cohort study of pre-Omicron and Omicron variants era. |
| title_full_unstemmed | Antibodies against SARS-CoV-2 in unvaccinated children hospitalized with COVID-19: An observational cohort study of pre-Omicron and Omicron variants era. |
| title_short | Antibodies against SARS-CoV-2 in unvaccinated children hospitalized with COVID-19: An observational cohort study of pre-Omicron and Omicron variants era. |
| title_sort | antibodies against sars cov 2 in unvaccinated children hospitalized with covid 19 an observational cohort study of pre omicron and omicron variants era |
| url | https://doi.org/10.1371/journal.pone.0297991 |
| work_keys_str_mv | AT rattaponuppala antibodiesagainstsarscov2inunvaccinatedchildrenhospitalizedwithcovid19anobservationalcohortstudyofpreomicronandomicronvariantsera AT phanthilasitthikarnkha antibodiesagainstsarscov2inunvaccinatedchildrenhospitalizedwithcovid19anobservationalcohortstudyofpreomicronandomicronvariantsera AT kiatichaifaksri antibodiesagainstsarscov2inunvaccinatedchildrenhospitalizedwithcovid19anobservationalcohortstudyofpreomicronandomicronvariantsera AT popekosalaraksa antibodiesagainstsarscov2inunvaccinatedchildrenhospitalizedwithcovid19anobservationalcohortstudyofpreomicronandomicronvariantsera AT leelawadeetechasatian antibodiesagainstsarscov2inunvaccinatedchildrenhospitalizedwithcovid19anobservationalcohortstudyofpreomicronandomicronvariantsera AT nattakarntantawarak antibodiesagainstsarscov2inunvaccinatedchildrenhospitalizedwithcovid19anobservationalcohortstudyofpreomicronandomicronvariantsera AT sysavanhnanthavongsa antibodiesagainstsarscov2inunvaccinatedchildrenhospitalizedwithcovid19anobservationalcohortstudyofpreomicronandomicronvariantsera |