Higher-order thalamic input to cortex selectively conveys state information
Summary: Communication among neocortical areas is largely thought to be mediated by long-range synaptic interactions between cortical neurons, with the thalamus providing only an initial relay of information from the sensory periphery. Higher-order thalamic nuclei receive strong synaptic inputs from...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124725000634 |
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| author | Garrett T. Neske Jessica A. Cardin |
| author_facet | Garrett T. Neske Jessica A. Cardin |
| author_sort | Garrett T. Neske |
| collection | DOAJ |
| description | Summary: Communication among neocortical areas is largely thought to be mediated by long-range synaptic interactions between cortical neurons, with the thalamus providing only an initial relay of information from the sensory periphery. Higher-order thalamic nuclei receive strong synaptic inputs from the cortex and send robust projections back to other cortical areas, providing a distinct and potentially critical route for corticocortical communication. However, the relative contributions of corticocortical and thalamocortical inputs to higher-order cortical function remain unclear. Using imaging of neurons and axon terminals in combination with optogenetic manipulations, we find that the higher-order visual thalamus of mice has a unique impact on the posterior medial visual cortex (PM). Whereas corticocortical projections from lower cortical areas convey robust visual information to PM, higher-order thalamocortical projections convey information about global arousal state. Together, these findings suggest a key role for the higher-order thalamus in providing contextual signals that may flexibly modulate cortical sensory processing. |
| format | Article |
| id | doaj-art-c102853f17ea428ca3fc0a4990ba5e09 |
| institution | OA Journals |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-c102853f17ea428ca3fc0a4990ba5e092025-08-20T02:13:31ZengElsevierCell Reports2211-12472025-02-0144211529210.1016/j.celrep.2025.115292Higher-order thalamic input to cortex selectively conveys state informationGarrett T. Neske0Jessica A. Cardin1Department of Neuroscience, Kavli Institute for Neuroscience, Wu Tsai Neuroscience Institute, Yale University, New Haven, CT, USADepartment of Neuroscience, Kavli Institute for Neuroscience, Wu Tsai Neuroscience Institute, Yale University, New Haven, CT, USA; Corresponding authorSummary: Communication among neocortical areas is largely thought to be mediated by long-range synaptic interactions between cortical neurons, with the thalamus providing only an initial relay of information from the sensory periphery. Higher-order thalamic nuclei receive strong synaptic inputs from the cortex and send robust projections back to other cortical areas, providing a distinct and potentially critical route for corticocortical communication. However, the relative contributions of corticocortical and thalamocortical inputs to higher-order cortical function remain unclear. Using imaging of neurons and axon terminals in combination with optogenetic manipulations, we find that the higher-order visual thalamus of mice has a unique impact on the posterior medial visual cortex (PM). Whereas corticocortical projections from lower cortical areas convey robust visual information to PM, higher-order thalamocortical projections convey information about global arousal state. Together, these findings suggest a key role for the higher-order thalamus in providing contextual signals that may flexibly modulate cortical sensory processing.http://www.sciencedirect.com/science/article/pii/S2211124725000634CP: Neuroscience |
| spellingShingle | Garrett T. Neske Jessica A. Cardin Higher-order thalamic input to cortex selectively conveys state information Cell Reports CP: Neuroscience |
| title | Higher-order thalamic input to cortex selectively conveys state information |
| title_full | Higher-order thalamic input to cortex selectively conveys state information |
| title_fullStr | Higher-order thalamic input to cortex selectively conveys state information |
| title_full_unstemmed | Higher-order thalamic input to cortex selectively conveys state information |
| title_short | Higher-order thalamic input to cortex selectively conveys state information |
| title_sort | higher order thalamic input to cortex selectively conveys state information |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124725000634 |
| work_keys_str_mv | AT garretttneske higherorderthalamicinputtocortexselectivelyconveysstateinformation AT jessicaacardin higherorderthalamicinputtocortexselectivelyconveysstateinformation |