SiRCle (Signature Regulatory Clustering) model integration reveals mechanisms of phenotype regulation in renal cancer

SiRCle (Signature Regulatory Clustering) model integration reveals mechanisms of phenotype regulation in renal cancer

Abstract Background Clear cell renal cell carcinoma (ccRCC) tumours develop and progress via complex remodelling of the kidney epigenome, transcriptome, proteome and metabolome. Given the subsequent tumour and inter-patient heterogeneity, drug-based treatments report limited success, calling for mul...

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Bibliographic Details
Main Authors: Ariane Mora, Christina Schmidt, Brad Balderson, Christian Frezza, Mikael Bodén
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Genome Medicine
Subjects:
Integration
Multi-omics
Regulation
Machine learning
Variational autoencoder
Clear cell renal cell carcinoma
Online Access:https://doi.org/10.1186/s13073-024-01415-3
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