Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation
Elevated FGF-23 is a predictor of mortality and is associated with LVH in CKD. It may be a biomarker or a direct toxin. We assessed the relationship between FGF-23 and LVH in CKD using CMRI. In vitro we studied the effect of phosphate, FGF-23, and Klotho on E-selectin and VCAM production in HUVECs....
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.4061/2011/297070 |
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| author | Kathryn K. Stevens Emily P. McQuarrie William Sands Dianne Z. Hillyard Rajan K. Patel Patrick B. Mark Alan G. Jardine |
| author_facet | Kathryn K. Stevens Emily P. McQuarrie William Sands Dianne Z. Hillyard Rajan K. Patel Patrick B. Mark Alan G. Jardine |
| author_sort | Kathryn K. Stevens |
| collection | DOAJ |
| description | Elevated FGF-23 is a predictor of mortality and is associated with LVH in CKD. It may be a biomarker or a direct toxin. We assessed the relationship between FGF-23 and LVH in CKD using CMRI. In vitro we studied the effect of phosphate, FGF-23, and Klotho on E-selectin and VCAM production in HUVECs. FGF-23 concentration correlates negatively with eGFR and positively with LVMI. FGF-23 was an independent predictor of LVH in CKD. E-selectin and VCAM production was elevated in HUVECs cultured in high phosphate with FGF-23 or Klotho. This effect was attenuated in cells exposed to both FGF-23 and Klotho. FGF-23 is an independent predictor of LVH as measured by CMRI. We show preliminary data which supports that FGF-23 is toxic resulting in activation of the vascular endothelium. We do not prove causality with elevated FGF-23 and LVH. Further research should ascertain if lowering levels of FGF-23 translates to improved clinical outcomes. |
| format | Article |
| id | doaj-art-c0ffd1a3298d49cd86603239a957438a |
| institution | DOAJ |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-c0ffd1a3298d49cd86603239a957438a2025-08-20T03:23:24ZengWileyInternational Journal of Nephrology2090-214X2090-21582011-01-01201110.4061/2011/297070297070Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule FormationKathryn K. Stevens0Emily P. McQuarrie1William Sands2Dianne Z. Hillyard3Rajan K. Patel4Patrick B. Mark5Alan G. Jardine6Renal Research Group, ICAMS, University of Glasgow, 126 University Place, Glasgow G12 8TA, UKRenal Research Group, ICAMS, University of Glasgow, 126 University Place, Glasgow G12 8TA, UKRenal Research Group, ICAMS, University of Glasgow, 126 University Place, Glasgow G12 8TA, UKRenal Research Group, ICAMS, University of Glasgow, 126 University Place, Glasgow G12 8TA, UKRenal Research Group, ICAMS, University of Glasgow, 126 University Place, Glasgow G12 8TA, UKRenal Research Group, ICAMS, University of Glasgow, 126 University Place, Glasgow G12 8TA, UKRenal Research Group, ICAMS, University of Glasgow, 126 University Place, Glasgow G12 8TA, UKElevated FGF-23 is a predictor of mortality and is associated with LVH in CKD. It may be a biomarker or a direct toxin. We assessed the relationship between FGF-23 and LVH in CKD using CMRI. In vitro we studied the effect of phosphate, FGF-23, and Klotho on E-selectin and VCAM production in HUVECs. FGF-23 concentration correlates negatively with eGFR and positively with LVMI. FGF-23 was an independent predictor of LVH in CKD. E-selectin and VCAM production was elevated in HUVECs cultured in high phosphate with FGF-23 or Klotho. This effect was attenuated in cells exposed to both FGF-23 and Klotho. FGF-23 is an independent predictor of LVH as measured by CMRI. We show preliminary data which supports that FGF-23 is toxic resulting in activation of the vascular endothelium. We do not prove causality with elevated FGF-23 and LVH. Further research should ascertain if lowering levels of FGF-23 translates to improved clinical outcomes.http://dx.doi.org/10.4061/2011/297070 |
| spellingShingle | Kathryn K. Stevens Emily P. McQuarrie William Sands Dianne Z. Hillyard Rajan K. Patel Patrick B. Mark Alan G. Jardine Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation International Journal of Nephrology |
| title | Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation |
| title_full | Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation |
| title_fullStr | Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation |
| title_full_unstemmed | Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation |
| title_short | Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation |
| title_sort | fibroblast growth factor 23 predicts left ventricular mass and induces cell adhesion molecule formation |
| url | http://dx.doi.org/10.4061/2011/297070 |
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