Effect of non-fluoride agents on the prevention of dental caries in primary dentition: A systematic review.
<h4>Objective</h4>To assess the effect of non-fluoride agents on the prevention of dental caries in primary dentition.<h4>Materials and methods</h4>Medline, Web of Science, Embase, Cochrane Library, CBM and CNKI databases were searched to identify all the relevant articles pu...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0182221 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850169853084696576 |
|---|---|
| author | Yu Wang Jialing Li Weibin Sun Huang Li Richard D Cannon Li Mei |
| author_facet | Yu Wang Jialing Li Weibin Sun Huang Li Richard D Cannon Li Mei |
| author_sort | Yu Wang |
| collection | DOAJ |
| description | <h4>Objective</h4>To assess the effect of non-fluoride agents on the prevention of dental caries in primary dentition.<h4>Materials and methods</h4>Medline, Web of Science, Embase, Cochrane Library, CBM and CNKI databases were searched to identify all the relevant articles published prior to 16 December 2016. Grey literature was also searched. Randomized controlled human clinical trials in which non-fluoride agents were delivered by any method were considered.<h4>Results</h4>Of the 1,236 studies screened, 39 full articles were scrutinized and 14 selected for inclusion in the final sample. Five chemical agents, namely arginine, casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), chlorhexidine, triclosan and xylitol were investigated in these included studies. The cariostatic effects of non-fluoride agents in vivo were evaluated in comparison with fluoride or placebos in randomized controlled trials. There is evidence that the use of certain doses of xylitol may be effective in arresting dental caries in primary dentition. However, quantitative synthesis could not be carried out because of the clinical and methodological heterogeneity of the included studies.<h4>Conclusions</h4>A study at low risk of bias indicated that daily use of xylitol wipes is a useful adjunct for caries control in young children, however, this conclusion should be interpreted with caution as this study had a very limited sample size. Chlorhexidine and CPP-ACP may be more effective than a placebo in managing caries in primary dentition, but their effectiveness is borderline when compared with fluoride. Arginine-containing mint confection and 0.3% triclosan varnish were found to reduce caries development in primary teeth but the evidence was at high risk of bias. High quality randomized controlled trials are needed in order to make a conclusive recommendation. |
| format | Article |
| id | doaj-art-c0fc9f770d1744629febcf4b38548ddc |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-c0fc9f770d1744629febcf4b38548ddc2025-08-20T02:20:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01128e018222110.1371/journal.pone.0182221Effect of non-fluoride agents on the prevention of dental caries in primary dentition: A systematic review.Yu WangJialing LiWeibin SunHuang LiRichard D CannonLi Mei<h4>Objective</h4>To assess the effect of non-fluoride agents on the prevention of dental caries in primary dentition.<h4>Materials and methods</h4>Medline, Web of Science, Embase, Cochrane Library, CBM and CNKI databases were searched to identify all the relevant articles published prior to 16 December 2016. Grey literature was also searched. Randomized controlled human clinical trials in which non-fluoride agents were delivered by any method were considered.<h4>Results</h4>Of the 1,236 studies screened, 39 full articles were scrutinized and 14 selected for inclusion in the final sample. Five chemical agents, namely arginine, casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), chlorhexidine, triclosan and xylitol were investigated in these included studies. The cariostatic effects of non-fluoride agents in vivo were evaluated in comparison with fluoride or placebos in randomized controlled trials. There is evidence that the use of certain doses of xylitol may be effective in arresting dental caries in primary dentition. However, quantitative synthesis could not be carried out because of the clinical and methodological heterogeneity of the included studies.<h4>Conclusions</h4>A study at low risk of bias indicated that daily use of xylitol wipes is a useful adjunct for caries control in young children, however, this conclusion should be interpreted with caution as this study had a very limited sample size. Chlorhexidine and CPP-ACP may be more effective than a placebo in managing caries in primary dentition, but their effectiveness is borderline when compared with fluoride. Arginine-containing mint confection and 0.3% triclosan varnish were found to reduce caries development in primary teeth but the evidence was at high risk of bias. High quality randomized controlled trials are needed in order to make a conclusive recommendation.https://doi.org/10.1371/journal.pone.0182221 |
| spellingShingle | Yu Wang Jialing Li Weibin Sun Huang Li Richard D Cannon Li Mei Effect of non-fluoride agents on the prevention of dental caries in primary dentition: A systematic review. PLoS ONE |
| title | Effect of non-fluoride agents on the prevention of dental caries in primary dentition: A systematic review. |
| title_full | Effect of non-fluoride agents on the prevention of dental caries in primary dentition: A systematic review. |
| title_fullStr | Effect of non-fluoride agents on the prevention of dental caries in primary dentition: A systematic review. |
| title_full_unstemmed | Effect of non-fluoride agents on the prevention of dental caries in primary dentition: A systematic review. |
| title_short | Effect of non-fluoride agents on the prevention of dental caries in primary dentition: A systematic review. |
| title_sort | effect of non fluoride agents on the prevention of dental caries in primary dentition a systematic review |
| url | https://doi.org/10.1371/journal.pone.0182221 |
| work_keys_str_mv | AT yuwang effectofnonfluorideagentsonthepreventionofdentalcariesinprimarydentitionasystematicreview AT jialingli effectofnonfluorideagentsonthepreventionofdentalcariesinprimarydentitionasystematicreview AT weibinsun effectofnonfluorideagentsonthepreventionofdentalcariesinprimarydentitionasystematicreview AT huangli effectofnonfluorideagentsonthepreventionofdentalcariesinprimarydentitionasystematicreview AT richarddcannon effectofnonfluorideagentsonthepreventionofdentalcariesinprimarydentitionasystematicreview AT limei effectofnonfluorideagentsonthepreventionofdentalcariesinprimarydentitionasystematicreview |