AMPs inhibit the proliferation, migration, and invasion of lung cancer via the CHRM3/PI3K/AKT and CHRM3/MAPK pathways

AMPs inhibit the proliferation, migration, and invasion of lung cancer via the CHRM3/PI3K/AKT and CHRM3/MAPK pathways

AimsOur previous studies indicated that the overexpression of M3 muscarinic receptor (M3R/CHRM3) is related to a poor prognosis in patients with lung cancer and that Armillaria mellea polysaccharides (AMPs) can exhibit strong anticancer activity in vitro via apoptosis-related mechanisms in lung canc...

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Bibliographic Details
Main Authors: Jun Wu, Congcong Huang, Shangning Wang, Liuyan Chen, Quan Cheng, Shao Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Oncology
Subjects:
M3 muscarinic receptor
Armillaria mellea polysaccharide
migration
invasion
PI3K/AKT
MAPK
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1582040/full
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