Evaluation of the therapeutic efficacy of high-intensity focused ultrasound ablation combined with different drugs in the treatment of adenomyosis
Objectives To observe the therapeutic efficacy of high-intensity focused ultrasound (HIFU) combined with different pharmacological treatments for adenomyosis.Materials and methods A total of 126 patients with adenomyosis who underwent HIFU combined with pharmacological treatment were retrospectively...
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2384471 |
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| author | Yu Dai Ling Liu Guiyuan Yu Yan Peng Na Chen Jiahong Gao Qiuling Shi Ping Jin |
| author_facet | Yu Dai Ling Liu Guiyuan Yu Yan Peng Na Chen Jiahong Gao Qiuling Shi Ping Jin |
| author_sort | Yu Dai |
| collection | DOAJ |
| description | Objectives To observe the therapeutic efficacy of high-intensity focused ultrasound (HIFU) combined with different pharmacological treatments for adenomyosis.Materials and methods A total of 126 patients with adenomyosis who underwent HIFU combined with pharmacological treatment were retrospectively reviewed. Patients were treated with either dienogest (DNG) (Group A, N = 38) or GnRH-a (Group B, N = 88) for three months after HIFU, and received levonorgestrel-releasing intrauterine systems (LNG-IUS) at the end of the third month. Visual Analog Scale (VAS) and Pictorial Blood Loss Assessment Chart (PBAC) scores were used for evaluating symptom improvement.Results After propensity score matching (1:2), 38 patients were included in Group A and 76 in Group B. All patients showed significant improvement in VAS and PBAC scores after HIFU, but the PBAC score of Group A was significantly higher than that of patients in Group B at 18 months [11.50 (1.00, 29.50) vs. 0.00 (0.00, 16.50), p < 0.01] and 24 months [4.00 (0.25, 27.75) vs. 0.00 (0.00, 12.75), p = 0.04] after HIFU. Furthermore, patients in Group B had a greater uterine volume reduction at 24 months after HIFU than that of patients in Group A [51.00 (27.00, 62.00) vs. 30.00 (17.00, 42.75, p = 0.02)]. However, the adverse effects in Group A were lower than those in Group B [7 (15.79) vs. 35 (46.05), p < 0.01]. No significant difference was observed in the recurrence rate between the two groups.Conclusions HIFU combined with DNG and LNG-IUS is a safe and effective treatment for patients with adenomyosis. |
| format | Article |
| id | doaj-art-c0f0dfcb9a3841b0b9d2acd020a9600b |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
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| series | International Journal of Hyperthermia |
| spelling | doaj-art-c0f0dfcb9a3841b0b9d2acd020a9600b2025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2384471Evaluation of the therapeutic efficacy of high-intensity focused ultrasound ablation combined with different drugs in the treatment of adenomyosisYu Dai0Ling Liu1Guiyuan Yu2Yan Peng3Na Chen4Jiahong Gao5Qiuling Shi6Ping Jin7Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, ChinaShenzhen Maternity and Child Healthcare Hospital, Shenzhen, ChinaShenzhen Maternity and Child Healthcare Hospital, Shenzhen, ChinaShenzhen Maternity and Child Healthcare Hospital, Shenzhen, ChinaShenzhen Maternity and Child Healthcare Hospital, Shenzhen, ChinaShenzhen Maternity and Child Healthcare Hospital, Shenzhen, ChinaState Key Laboratory of Ultrasound in Medicine and Engineering, Chongqing Medical University, Chongqing, ChinaShenzhen Maternity and Child Healthcare Hospital, Shenzhen, ChinaObjectives To observe the therapeutic efficacy of high-intensity focused ultrasound (HIFU) combined with different pharmacological treatments for adenomyosis.Materials and methods A total of 126 patients with adenomyosis who underwent HIFU combined with pharmacological treatment were retrospectively reviewed. Patients were treated with either dienogest (DNG) (Group A, N = 38) or GnRH-a (Group B, N = 88) for three months after HIFU, and received levonorgestrel-releasing intrauterine systems (LNG-IUS) at the end of the third month. Visual Analog Scale (VAS) and Pictorial Blood Loss Assessment Chart (PBAC) scores were used for evaluating symptom improvement.Results After propensity score matching (1:2), 38 patients were included in Group A and 76 in Group B. All patients showed significant improvement in VAS and PBAC scores after HIFU, but the PBAC score of Group A was significantly higher than that of patients in Group B at 18 months [11.50 (1.00, 29.50) vs. 0.00 (0.00, 16.50), p < 0.01] and 24 months [4.00 (0.25, 27.75) vs. 0.00 (0.00, 12.75), p = 0.04] after HIFU. Furthermore, patients in Group B had a greater uterine volume reduction at 24 months after HIFU than that of patients in Group A [51.00 (27.00, 62.00) vs. 30.00 (17.00, 42.75, p = 0.02)]. However, the adverse effects in Group A were lower than those in Group B [7 (15.79) vs. 35 (46.05), p < 0.01]. No significant difference was observed in the recurrence rate between the two groups.Conclusions HIFU combined with DNG and LNG-IUS is a safe and effective treatment for patients with adenomyosis.https://www.tandfonline.com/doi/10.1080/02656736.2024.2384471Adenomyosishigh-intensity focused ultrasounddienogestGnRH-aLNG-IUS |
| spellingShingle | Yu Dai Ling Liu Guiyuan Yu Yan Peng Na Chen Jiahong Gao Qiuling Shi Ping Jin Evaluation of the therapeutic efficacy of high-intensity focused ultrasound ablation combined with different drugs in the treatment of adenomyosis International Journal of Hyperthermia Adenomyosis high-intensity focused ultrasound dienogest GnRH-a LNG-IUS |
| title | Evaluation of the therapeutic efficacy of high-intensity focused ultrasound ablation combined with different drugs in the treatment of adenomyosis |
| title_full | Evaluation of the therapeutic efficacy of high-intensity focused ultrasound ablation combined with different drugs in the treatment of adenomyosis |
| title_fullStr | Evaluation of the therapeutic efficacy of high-intensity focused ultrasound ablation combined with different drugs in the treatment of adenomyosis |
| title_full_unstemmed | Evaluation of the therapeutic efficacy of high-intensity focused ultrasound ablation combined with different drugs in the treatment of adenomyosis |
| title_short | Evaluation of the therapeutic efficacy of high-intensity focused ultrasound ablation combined with different drugs in the treatment of adenomyosis |
| title_sort | evaluation of the therapeutic efficacy of high intensity focused ultrasound ablation combined with different drugs in the treatment of adenomyosis |
| topic | Adenomyosis high-intensity focused ultrasound dienogest GnRH-a LNG-IUS |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2384471 |
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