The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis
Objective. The risk of atherosclerotic heart disease is increased in autoimmune thyroiditis, although the reason is not clear. Lipoprotein(a) (Lp(a)) excess has been identified as a powerful predictor of premature atherosclerotic vascular diseases. The aim of this study is to investigate the relatio...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/952729 |
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| author | D. O. Yetkin B. Dogantekin |
| author_facet | D. O. Yetkin B. Dogantekin |
| author_sort | D. O. Yetkin |
| collection | DOAJ |
| description | Objective. The risk of atherosclerotic heart disease is increased in autoimmune thyroiditis, although the reason is not clear. Lipoprotein(a) (Lp(a)) excess has been identified as a powerful predictor of premature atherosclerotic vascular diseases. The aim of this study is to investigate the relationship between Lp(a) levels and thyroid hormones in Hashimoto patients. Method. 154 premenopausal female Hashimoto patients (48 patients with overthypothyroid (OH), 50 patients with subclinical hypothyroid (SH), and 56 patients with euthyroid Hashimoto to (EH)) were enrolled in this study. The control group consists of 50 age matched volunteers. In every group, thyroid function tests and lipid parameters with Lp(a) were measured. Lp(a) excess was defined as Lp(a) > 30 mg/dL. Results. Total-C, LDL-C, TG, and Lp(a) levels were increased in Hashimoto group. Total-C, LDL-C, and TG levels were higher in SH group than in the control group. Total-C and LDL-C levels were also higher in EH group compared to controls. Lp(a) levels were similar in SH and EH groups with controls. However, excess Lp(a) was more common in subclinical hypothyroid and euthyroid Hashimoto group than in the control group. Conclusion. The Total-C and LDL-C levels and excess Lp(a) were higher even in euthyroid Hashimoto patients. Thyroid autoimmunity may have some effect on Lp(a) and lipid metabolism. |
| format | Article |
| id | doaj-art-c0efded80c3346e8bdbdb7c79a70a8a7 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-c0efded80c3346e8bdbdb7c79a70a8a72025-02-03T01:33:28ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/952729952729The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto ThyroiditisD. O. Yetkin0B. Dogantekin1Department of Endocrinology, Kolan International Hospital, 36384 Istanbul, TurkeyDepartment of Internal Medicine, Goztepe Education and Research Hospital, 34722 Istanbul, TurkeyObjective. The risk of atherosclerotic heart disease is increased in autoimmune thyroiditis, although the reason is not clear. Lipoprotein(a) (Lp(a)) excess has been identified as a powerful predictor of premature atherosclerotic vascular diseases. The aim of this study is to investigate the relationship between Lp(a) levels and thyroid hormones in Hashimoto patients. Method. 154 premenopausal female Hashimoto patients (48 patients with overthypothyroid (OH), 50 patients with subclinical hypothyroid (SH), and 56 patients with euthyroid Hashimoto to (EH)) were enrolled in this study. The control group consists of 50 age matched volunteers. In every group, thyroid function tests and lipid parameters with Lp(a) were measured. Lp(a) excess was defined as Lp(a) > 30 mg/dL. Results. Total-C, LDL-C, TG, and Lp(a) levels were increased in Hashimoto group. Total-C, LDL-C, and TG levels were higher in SH group than in the control group. Total-C and LDL-C levels were also higher in EH group compared to controls. Lp(a) levels were similar in SH and EH groups with controls. However, excess Lp(a) was more common in subclinical hypothyroid and euthyroid Hashimoto group than in the control group. Conclusion. The Total-C and LDL-C levels and excess Lp(a) were higher even in euthyroid Hashimoto patients. Thyroid autoimmunity may have some effect on Lp(a) and lipid metabolism.http://dx.doi.org/10.1155/2015/952729 |
| spellingShingle | D. O. Yetkin B. Dogantekin The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis International Journal of Endocrinology |
| title | The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis |
| title_full | The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis |
| title_fullStr | The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis |
| title_full_unstemmed | The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis |
| title_short | The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis |
| title_sort | lipid parameters and lipoprotein a excess in hashimoto thyroiditis |
| url | http://dx.doi.org/10.1155/2015/952729 |
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