Humanized Mouse Models for Immuno-Oncology Research: A Review and Implications in Lung Cancer Research
Cancer immunotherapy has brought significant clinical benefits to patients with cancer, including those with lung cancer. Patient-derived tumor xenograft mouse models have become the preferred animal model for translational cancer research and preclinical studies. Given the unmet need for improved p...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | JTO Clinical and Research Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666364324001516 |
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| author | Cheol-Kyu Park, MD, PhD Maryam Khalil, BSc Nhu-An Pham, PhD Stephanie Wong, BSc Dalam Ly, PhD Adrian Sacher, MD, FRCPC Ming-Sound Tsao, MD, FRCPC |
| author_facet | Cheol-Kyu Park, MD, PhD Maryam Khalil, BSc Nhu-An Pham, PhD Stephanie Wong, BSc Dalam Ly, PhD Adrian Sacher, MD, FRCPC Ming-Sound Tsao, MD, FRCPC |
| author_sort | Cheol-Kyu Park, MD, PhD |
| collection | DOAJ |
| description | Cancer immunotherapy has brought significant clinical benefits to patients with cancer, including those with lung cancer. Patient-derived tumor xenograft mouse models have become the preferred animal model for translational cancer research and preclinical studies. Given the unmet need for improved predictive models in immuno-oncology, humanized mouse models which are co-engrafted with both human tumors and immune system components have been used to investigate novel immunotherapeutics. These models have similarly been used to predict immune-related adverse events and to develop predictive biomarkers. This review summarizes key concepts related to humanized mouse models. We highlight the various approaches to generate them, factors that are critical to successfully establishing such models, their respective limitations, and considerations in model selection for preclinical lung cancer immuno-oncology research and therapeutic studies. |
| format | Article |
| id | doaj-art-c0eccf155f9a42e6ad3f7f4a48ac9baa |
| institution | Kabale University |
| issn | 2666-3643 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JTO Clinical and Research Reports |
| spelling | doaj-art-c0eccf155f9a42e6ad3f7f4a48ac9baa2025-02-05T04:32:40ZengElsevierJTO Clinical and Research Reports2666-36432025-03-0163100781Humanized Mouse Models for Immuno-Oncology Research: A Review and Implications in Lung Cancer ResearchCheol-Kyu Park, MD, PhD0Maryam Khalil, BSc1Nhu-An Pham, PhD2Stephanie Wong, BSc3Dalam Ly, PhD4Adrian Sacher, MD, FRCPC5Ming-Sound Tsao, MD, FRCPC6Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hosptial, Hwasun, Republic of Korea; Research Institute of Medical Science, Chonnam National University, Gwangju, Republic of KoreaPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University Health Network, Toronto, Ontario, CanadaPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, CanadaPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Immunology, University of Toronto, Toronto, Ontario, CanadaPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, CanadaPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Immunology, University of Toronto, Toronto, Ontario, Canada; Division of Medical Oncology, Department of Medicine, University of Toronto, Toronto, Ontario, CanadaPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University Health Network, Toronto, Ontario, Canada; Department of Medical Biophysics, University Health Network, Toronto, Ontario, Canada; Corresponding author. Address for correspondence: Ming-Sound Tsao, MD, FRCPC, Princess Margaret Cancer Research Tower, 101 College Street, Toronto, Ontario M5G 1L7, Canada.Cancer immunotherapy has brought significant clinical benefits to patients with cancer, including those with lung cancer. Patient-derived tumor xenograft mouse models have become the preferred animal model for translational cancer research and preclinical studies. Given the unmet need for improved predictive models in immuno-oncology, humanized mouse models which are co-engrafted with both human tumors and immune system components have been used to investigate novel immunotherapeutics. These models have similarly been used to predict immune-related adverse events and to develop predictive biomarkers. This review summarizes key concepts related to humanized mouse models. We highlight the various approaches to generate them, factors that are critical to successfully establishing such models, their respective limitations, and considerations in model selection for preclinical lung cancer immuno-oncology research and therapeutic studies.http://www.sciencedirect.com/science/article/pii/S2666364324001516Lung cancerImmunotherapyHumanized mouse modelsPatient-derived xenograft |
| spellingShingle | Cheol-Kyu Park, MD, PhD Maryam Khalil, BSc Nhu-An Pham, PhD Stephanie Wong, BSc Dalam Ly, PhD Adrian Sacher, MD, FRCPC Ming-Sound Tsao, MD, FRCPC Humanized Mouse Models for Immuno-Oncology Research: A Review and Implications in Lung Cancer Research JTO Clinical and Research Reports Lung cancer Immunotherapy Humanized mouse models Patient-derived xenograft |
| title | Humanized Mouse Models for Immuno-Oncology Research: A Review and Implications in Lung Cancer Research |
| title_full | Humanized Mouse Models for Immuno-Oncology Research: A Review and Implications in Lung Cancer Research |
| title_fullStr | Humanized Mouse Models for Immuno-Oncology Research: A Review and Implications in Lung Cancer Research |
| title_full_unstemmed | Humanized Mouse Models for Immuno-Oncology Research: A Review and Implications in Lung Cancer Research |
| title_short | Humanized Mouse Models for Immuno-Oncology Research: A Review and Implications in Lung Cancer Research |
| title_sort | humanized mouse models for immuno oncology research a review and implications in lung cancer research |
| topic | Lung cancer Immunotherapy Humanized mouse models Patient-derived xenograft |
| url | http://www.sciencedirect.com/science/article/pii/S2666364324001516 |
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