Physicochemical Property Effects on Immune Modulating Polymeric Nanoparticles: Potential Applications in Spinal Cord Injury
Daniel J Kolpek,1 Jaechang Kim,1 Hisham Mohammed,1 John C Gensel,2 Jonghyuck Park1,2 1Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA; 2Spinal Cord and Brain Injury Research Center, Department of Physiology, College of Medicine, University of Ke...
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Dove Medical Press
2024-12-01
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| Series: | International Journal of Nanomedicine |
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| Online Access: | https://www.dovepress.com/physicochemical-property-effects-on-immune-modulating-polymeric-nanopa-peer-reviewed-fulltext-article-IJN |
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| author | Kolpek DJ Kim J Mohammed H Gensel JC Park J |
| author_facet | Kolpek DJ Kim J Mohammed H Gensel JC Park J |
| author_sort | Kolpek DJ |
| collection | DOAJ |
| description | Daniel J Kolpek,1 Jaechang Kim,1 Hisham Mohammed,1 John C Gensel,2 Jonghyuck Park1,2 1Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA; 2Spinal Cord and Brain Injury Research Center, Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USACorrespondence: Jonghyuck Park, Pharmaceutical Sciences, College of Pharmacy, Spinal Cord and Brain Injury Research Center, College of Medicine, University of Kentucky, 789 S. Limestone St, Lexington, KY, 40506, USA, Tel +1 859 257 1850, Email jonghyuck.park@uky.eduAbstract: Nanoparticles (NPs) offer promising potential as therapeutic agents for inflammation-related diseases, owing to their capabilities in drug delivery and immune modulation. In preclinical studies focusing on spinal cord injury (SCI), polymeric NPs have demonstrated the ability to reprogram innate immune cells. This reprogramming results in redirecting immune cells away from the injury site, downregulating pro-inflammatory signaling, and promoting a regenerative environment post-injury. However, to fully understand the mechanisms driving these effects and maximize therapeutic efficacy, it is crucial to assess NP interactions with innate immune cells. This review examines how the physicochemical properties of polymeric NPs influence their modulation of the immune system. To achieve this, the review delves into the roles played by innate immune cells in SCI and investigates how various NP properties influence cellular interactions and subsequent immune modulation. Key NP properties such as size, surface charge, molecular weight, shape/morphology, surface functionalization, and polymer composition are thoroughly examined. Furthermore, the review establishes connections between these properties and their effects on the immunomodulatory functions of NPs. Ultimately, this review suggests that leveraging NPs and their physicochemical properties could serve as a promising therapeutic strategy for treating SCI and potentially other inflammatory diseases.Keywords: nanomaterials, biodegradable carriers, particle engineering, biomaterial-based therapies, neuroinflammation, nerve tissue repair |
| format | Article |
| id | doaj-art-c0ec493c9c8a40979b88c7976a44f135 |
| institution | OA Journals |
| issn | 1178-2013 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj-art-c0ec493c9c8a40979b88c7976a44f1352025-08-20T01:59:08ZengDove Medical PressInternational Journal of Nanomedicine1178-20132024-12-01Volume 19133571337498291Physicochemical Property Effects on Immune Modulating Polymeric Nanoparticles: Potential Applications in Spinal Cord InjuryKolpek DJKim JMohammed HGensel JCPark JDaniel J Kolpek,1 Jaechang Kim,1 Hisham Mohammed,1 John C Gensel,2 Jonghyuck Park1,2 1Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA; 2Spinal Cord and Brain Injury Research Center, Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USACorrespondence: Jonghyuck Park, Pharmaceutical Sciences, College of Pharmacy, Spinal Cord and Brain Injury Research Center, College of Medicine, University of Kentucky, 789 S. Limestone St, Lexington, KY, 40506, USA, Tel +1 859 257 1850, Email jonghyuck.park@uky.eduAbstract: Nanoparticles (NPs) offer promising potential as therapeutic agents for inflammation-related diseases, owing to their capabilities in drug delivery and immune modulation. In preclinical studies focusing on spinal cord injury (SCI), polymeric NPs have demonstrated the ability to reprogram innate immune cells. This reprogramming results in redirecting immune cells away from the injury site, downregulating pro-inflammatory signaling, and promoting a regenerative environment post-injury. However, to fully understand the mechanisms driving these effects and maximize therapeutic efficacy, it is crucial to assess NP interactions with innate immune cells. This review examines how the physicochemical properties of polymeric NPs influence their modulation of the immune system. To achieve this, the review delves into the roles played by innate immune cells in SCI and investigates how various NP properties influence cellular interactions and subsequent immune modulation. Key NP properties such as size, surface charge, molecular weight, shape/morphology, surface functionalization, and polymer composition are thoroughly examined. Furthermore, the review establishes connections between these properties and their effects on the immunomodulatory functions of NPs. Ultimately, this review suggests that leveraging NPs and their physicochemical properties could serve as a promising therapeutic strategy for treating SCI and potentially other inflammatory diseases.Keywords: nanomaterials, biodegradable carriers, particle engineering, biomaterial-based therapies, neuroinflammation, nerve tissue repairhttps://www.dovepress.com/physicochemical-property-effects-on-immune-modulating-polymeric-nanopa-peer-reviewed-fulltext-article-IJNnanomaterialsbiodegradable carriersparticle engineeringbiomaterial-based therapiesneuroinflammationnerve tissue repair |
| spellingShingle | Kolpek DJ Kim J Mohammed H Gensel JC Park J Physicochemical Property Effects on Immune Modulating Polymeric Nanoparticles: Potential Applications in Spinal Cord Injury International Journal of Nanomedicine nanomaterials biodegradable carriers particle engineering biomaterial-based therapies neuroinflammation nerve tissue repair |
| title | Physicochemical Property Effects on Immune Modulating Polymeric Nanoparticles: Potential Applications in Spinal Cord Injury |
| title_full | Physicochemical Property Effects on Immune Modulating Polymeric Nanoparticles: Potential Applications in Spinal Cord Injury |
| title_fullStr | Physicochemical Property Effects on Immune Modulating Polymeric Nanoparticles: Potential Applications in Spinal Cord Injury |
| title_full_unstemmed | Physicochemical Property Effects on Immune Modulating Polymeric Nanoparticles: Potential Applications in Spinal Cord Injury |
| title_short | Physicochemical Property Effects on Immune Modulating Polymeric Nanoparticles: Potential Applications in Spinal Cord Injury |
| title_sort | physicochemical property effects on immune modulating polymeric nanoparticles potential applications in spinal cord injury |
| topic | nanomaterials biodegradable carriers particle engineering biomaterial-based therapies neuroinflammation nerve tissue repair |
| url | https://www.dovepress.com/physicochemical-property-effects-on-immune-modulating-polymeric-nanopa-peer-reviewed-fulltext-article-IJN |
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