Beware of host immune responses towards bacteriophages potentially impacting phage therapy
Abstract The rising spread of antimicrobial resistance challenges animal welfare, productivity and food supply with respect to bacterial infections in different livestock species. Bacteriophages offer alternative means to control infections with resistant bacteria. This work investigated the host im...
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| Format: | Article |
| Language: | English |
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BMC
2025-08-01
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| Series: | Veterinary Research |
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| Online Access: | https://doi.org/10.1186/s13567-025-01600-1 |
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| author | Thomas Démoulins Jérémy D. R. Cherbuin Thatcha Yimthin Lukas Eggerschwiler Fazal Adnan Joerg Jores |
| author_facet | Thomas Démoulins Jérémy D. R. Cherbuin Thatcha Yimthin Lukas Eggerschwiler Fazal Adnan Joerg Jores |
| author_sort | Thomas Démoulins |
| collection | DOAJ |
| description | Abstract The rising spread of antimicrobial resistance challenges animal welfare, productivity and food supply with respect to bacterial infections in different livestock species. Bacteriophages offer alternative means to control infections with resistant bacteria. This work investigated the host immune responses towards lytic bacteriophages K and T1, acting respectively on Gram-positive or Gram-negative bacteria. We employed an ex vivo platform to decipher various immune responses elicited by primary blood cells of eight outbred cattle. Bacteriophage K was not recognized whereas bacteriophage T1 induced a profound immune response. Therefore, prior characterization of host immune responses towards therapeutic phages should be considered before therapy starts. |
| format | Article |
| id | doaj-art-c0eacc7fa3cf44e18bde617d2b197cac |
| institution | Kabale University |
| issn | 1297-9716 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Veterinary Research |
| spelling | doaj-art-c0eacc7fa3cf44e18bde617d2b197cac2025-08-20T03:43:30ZengBMCVeterinary Research1297-97162025-08-015611810.1186/s13567-025-01600-1Beware of host immune responses towards bacteriophages potentially impacting phage therapyThomas Démoulins0Jérémy D. R. Cherbuin1Thatcha Yimthin2Lukas Eggerschwiler3Fazal Adnan4Joerg Jores5Institute of Veterinary Bacteriology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of BernInstitute of Veterinary Bacteriology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of BernInstitute of Veterinary Bacteriology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of BernResearch Contracts Animals GroupAtta Ur Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST)Institute of Veterinary Bacteriology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of BernAbstract The rising spread of antimicrobial resistance challenges animal welfare, productivity and food supply with respect to bacterial infections in different livestock species. Bacteriophages offer alternative means to control infections with resistant bacteria. This work investigated the host immune responses towards lytic bacteriophages K and T1, acting respectively on Gram-positive or Gram-negative bacteria. We employed an ex vivo platform to decipher various immune responses elicited by primary blood cells of eight outbred cattle. Bacteriophage K was not recognized whereas bacteriophage T1 induced a profound immune response. Therefore, prior characterization of host immune responses towards therapeutic phages should be considered before therapy starts.https://doi.org/10.1186/s13567-025-01600-1Bacteriophagesex vivo immune responsephage therapycattle |
| spellingShingle | Thomas Démoulins Jérémy D. R. Cherbuin Thatcha Yimthin Lukas Eggerschwiler Fazal Adnan Joerg Jores Beware of host immune responses towards bacteriophages potentially impacting phage therapy Veterinary Research Bacteriophages ex vivo immune response phage therapy cattle |
| title | Beware of host immune responses towards bacteriophages potentially impacting phage therapy |
| title_full | Beware of host immune responses towards bacteriophages potentially impacting phage therapy |
| title_fullStr | Beware of host immune responses towards bacteriophages potentially impacting phage therapy |
| title_full_unstemmed | Beware of host immune responses towards bacteriophages potentially impacting phage therapy |
| title_short | Beware of host immune responses towards bacteriophages potentially impacting phage therapy |
| title_sort | beware of host immune responses towards bacteriophages potentially impacting phage therapy |
| topic | Bacteriophages ex vivo immune response phage therapy cattle |
| url | https://doi.org/10.1186/s13567-025-01600-1 |
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