Antiemetic activity of Sesamol possibly through serotonergic and dopaminergic receptor interaction pathways: In vivo and in silico studies
Sesamol (SEL) is 3,4-methylenedioxyphenol isolated from sesame seeds. This study aimed to evaluate the antiemetic activity of SEL, supported by in vivo and in silico studies. Further, molecular docking was carried out to understand the molecular interaction between selected ligands and different rec...
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| Language: | English |
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Elsevier
2025-03-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000441 |
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| author | Touhidul Islam Tanim Ayman M. Al-Qaaneh Raihan Chowdhury Md. Shimul Bhuia Tabassum Islam Md Showkoth Akbor Md. Tahajul Islam Md. Mohasin Miah Ali Raza Ishaq Mostafa A. Abdel-Maksoud Mohamed A. El-Tayeb Mohamed El-Shazly Muhammad Torequl Islam Heba A.S. El-Nashar |
| author_facet | Touhidul Islam Tanim Ayman M. Al-Qaaneh Raihan Chowdhury Md. Shimul Bhuia Tabassum Islam Md Showkoth Akbor Md. Tahajul Islam Md. Mohasin Miah Ali Raza Ishaq Mostafa A. Abdel-Maksoud Mohamed A. El-Tayeb Mohamed El-Shazly Muhammad Torequl Islam Heba A.S. El-Nashar |
| author_sort | Touhidul Islam Tanim |
| collection | DOAJ |
| description | Sesamol (SEL) is 3,4-methylenedioxyphenol isolated from sesame seeds. This study aimed to evaluate the antiemetic activity of SEL, supported by in vivo and in silico studies. Further, molecular docking was carried out to understand the molecular interaction between selected ligands and different receptors liable for mediating emesis. SEL (25 and 50 mg/kg) showed dose-dependent elevation in latency (133.20 ± 2.19 and 293.00 ± 5.27 s) and diminishment in the retching number (16.40 ± 1.15 and 9.40 ± 1.04 times), compared to control. Additionally, SEL can antagonize the activity of ondansetron (OND; 5 mg/kg) and domperidone (DOM; 7 mg/kg), resulting in a decrease in latency (256.00 ± 9.59 and 253.00 ± 2.79 s) and enhancing the number of retches (11.80 ± 0.82 and 12.60 ± 1.04) in combination rather than OND and DOM alone. An in-silico study showed SEL has moderate binding activity (−5.9 and − 5.7 kcal/mol) for serotonin (5HT3) and dopaminergic (D2) receptors, respectively, via hydrogen and hydrophobic bonds with specific amino acid residues. |
| format | Article |
| id | doaj-art-c0e9b9dfbba84385bae222330fcd0550 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-c0e9b9dfbba84385bae222330fcd05502025-02-10T04:34:17ZengElsevierJournal of Functional Foods1756-46462025-03-01126106702Antiemetic activity of Sesamol possibly through serotonergic and dopaminergic receptor interaction pathways: In vivo and in silico studiesTouhidul Islam Tanim0Ayman M. Al-Qaaneh1Raihan Chowdhury2Md. Shimul Bhuia3Tabassum Islam4Md Showkoth Akbor5Md. Tahajul Islam6Md. Mohasin Miah7Ali Raza Ishaq8Mostafa A. Abdel-Maksoud9Mohamed A. El-Tayeb10Mohamed El-Shazly11Muhammad Torequl Islam12Heba A.S. El-Nashar13Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, BangladeshFaculty of Allied Medical Sciences, Al-Balqa Applied University (BAU), Al-Salt 19117, Jordan; Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology (JUST), Irbid, 22110, JordanDepartment of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, BangladeshDepartment of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, BangladeshDepartment of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, BangladeshDepartment of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, BangladeshDepartment of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, BangladeshDepartment of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, BangladeshState Key Laboratory of Biocatalysis and Enzyme Engineering, Environmental Microbial Technology Center of Hubei, College of Life Science, Hubei University, Wuhan, ChinaDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, 11566 Cairo, Egypt; Corresponding authors at: Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, 11566 Cairo, Egypt.Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh; Department of Pharmacy, East West University, Dhaka 1212, Bangladesh; Corresponding author at: Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, 11566 Cairo, Egypt; Corresponding authors at: Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, 11566 Cairo, Egypt.Sesamol (SEL) is 3,4-methylenedioxyphenol isolated from sesame seeds. This study aimed to evaluate the antiemetic activity of SEL, supported by in vivo and in silico studies. Further, molecular docking was carried out to understand the molecular interaction between selected ligands and different receptors liable for mediating emesis. SEL (25 and 50 mg/kg) showed dose-dependent elevation in latency (133.20 ± 2.19 and 293.00 ± 5.27 s) and diminishment in the retching number (16.40 ± 1.15 and 9.40 ± 1.04 times), compared to control. Additionally, SEL can antagonize the activity of ondansetron (OND; 5 mg/kg) and domperidone (DOM; 7 mg/kg), resulting in a decrease in latency (256.00 ± 9.59 and 253.00 ± 2.79 s) and enhancing the number of retches (11.80 ± 0.82 and 12.60 ± 1.04) in combination rather than OND and DOM alone. An in-silico study showed SEL has moderate binding activity (−5.9 and − 5.7 kcal/mol) for serotonin (5HT3) and dopaminergic (D2) receptors, respectively, via hydrogen and hydrophobic bonds with specific amino acid residues.http://www.sciencedirect.com/science/article/pii/S1756464625000441AntiemeticSesamolSesame seedsDopaminergicIn silico studiesSerotonin |
| spellingShingle | Touhidul Islam Tanim Ayman M. Al-Qaaneh Raihan Chowdhury Md. Shimul Bhuia Tabassum Islam Md Showkoth Akbor Md. Tahajul Islam Md. Mohasin Miah Ali Raza Ishaq Mostafa A. Abdel-Maksoud Mohamed A. El-Tayeb Mohamed El-Shazly Muhammad Torequl Islam Heba A.S. El-Nashar Antiemetic activity of Sesamol possibly through serotonergic and dopaminergic receptor interaction pathways: In vivo and in silico studies Journal of Functional Foods Antiemetic Sesamol Sesame seeds Dopaminergic In silico studies Serotonin |
| title | Antiemetic activity of Sesamol possibly through serotonergic and dopaminergic receptor interaction pathways: In vivo and in silico studies |
| title_full | Antiemetic activity of Sesamol possibly through serotonergic and dopaminergic receptor interaction pathways: In vivo and in silico studies |
| title_fullStr | Antiemetic activity of Sesamol possibly through serotonergic and dopaminergic receptor interaction pathways: In vivo and in silico studies |
| title_full_unstemmed | Antiemetic activity of Sesamol possibly through serotonergic and dopaminergic receptor interaction pathways: In vivo and in silico studies |
| title_short | Antiemetic activity of Sesamol possibly through serotonergic and dopaminergic receptor interaction pathways: In vivo and in silico studies |
| title_sort | antiemetic activity of sesamol possibly through serotonergic and dopaminergic receptor interaction pathways in vivo and in silico studies |
| topic | Antiemetic Sesamol Sesame seeds Dopaminergic In silico studies Serotonin |
| url | http://www.sciencedirect.com/science/article/pii/S1756464625000441 |
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