Clinical and epidemiological characteristics of children with germ cell tumors: A single center experience in a developing country
Germ cell tumor (GCT) is a rare malignancy accounting for 2-3% of all pediatric tumors. The overall survival rate of children and adolescents with GCT is more than 80% after adopting combined therapy. The aim of this study is to review clinical presentation, management, and outcome in a single-cent...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2017-08-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/1008 |
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| author | Sonay İncesoy-Özdemir Ulya Ertem Gürses Şahin Ceyhun Bozkurt Nazmiye Yüksek Ayşe Ceyda Ören Eda Balkaya Afra Alkan |
| author_facet | Sonay İncesoy-Özdemir Ulya Ertem Gürses Şahin Ceyhun Bozkurt Nazmiye Yüksek Ayşe Ceyda Ören Eda Balkaya Afra Alkan |
| author_sort | Sonay İncesoy-Özdemir |
| collection | DOAJ |
| description |
Germ cell tumor (GCT) is a rare malignancy accounting for 2-3% of all pediatric tumors. The overall survival rate of children and adolescents with GCT is more than 80% after adopting combined therapy. The aim of this study is to review clinical presentation, management, and outcome in a single-center series with extracranial GCT. Clinical characteristics, pathologic presentations, and survival outcomes of 101 children with GCT, treated at our hospital from 1988 to 2011, were analyzed. Sixty-two of patients were female and 39 of them were male. Fifty-eight (57%) patients had gonadal tumor (24 testicular, 34 ovarian), 43 (43%) extragonadal. Histologically, teratomas were found most frequently (26 mature, 10 immature), followed by yolk sac tumors (n: 33), mixed malignant tumors (n: 13), embryonal carcinoma (n: 10), disgerminoma (n: 8) and seminoma (n: 1). Twenty-six patients were diagnosed as mature teratoma and we excluded them in the evaluation of staging and survival. Five-year overall and relaps-free survival were 80.3% (mean follow-up time: 215.8 months) and 73.4% (mean follow-up time: 176.2 months), respectively. Five-year survival rates were 93.2% and 90.2% in malign GCTs diagnosed after 1999.
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| format | Article |
| id | doaj-art-c0e04a919ab041fa9b3701b6a810a5dc |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2017-08-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-c0e04a919ab041fa9b3701b6a810a5dc2025-08-20T02:01:51ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212017-08-0159410.24953/turkjped.2017.04.007Clinical and epidemiological characteristics of children with germ cell tumors: A single center experience in a developing countrySonay İncesoy-Özdemir0Ulya Ertem1Gürses Şahin2Ceyhun Bozkurt3Nazmiye Yüksek4Ayşe Ceyda Ören5Eda Balkaya6Afra Alkan7Departments of Pediatric Oncology, Yıldırım Beyazıt University, Ankara, Turkey.Department of Pediatric Oncology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey.Department of Pediatric Oncology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey.Department of Pediatric Oncology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey.Department of Pediatric Oncology, Zonguldak Karaelmas University, Zonguldak, Turkey.Department of Pediatric Oncology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey.Department of Pediatric Oncology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey.Departments of Biostatistics, Yıldırım Beyazıt University, Ankara, Turkey. Germ cell tumor (GCT) is a rare malignancy accounting for 2-3% of all pediatric tumors. The overall survival rate of children and adolescents with GCT is more than 80% after adopting combined therapy. The aim of this study is to review clinical presentation, management, and outcome in a single-center series with extracranial GCT. Clinical characteristics, pathologic presentations, and survival outcomes of 101 children with GCT, treated at our hospital from 1988 to 2011, were analyzed. Sixty-two of patients were female and 39 of them were male. Fifty-eight (57%) patients had gonadal tumor (24 testicular, 34 ovarian), 43 (43%) extragonadal. Histologically, teratomas were found most frequently (26 mature, 10 immature), followed by yolk sac tumors (n: 33), mixed malignant tumors (n: 13), embryonal carcinoma (n: 10), disgerminoma (n: 8) and seminoma (n: 1). Twenty-six patients were diagnosed as mature teratoma and we excluded them in the evaluation of staging and survival. Five-year overall and relaps-free survival were 80.3% (mean follow-up time: 215.8 months) and 73.4% (mean follow-up time: 176.2 months), respectively. Five-year survival rates were 93.2% and 90.2% in malign GCTs diagnosed after 1999. https://turkjpediatr.org/article/view/1008childrengerm cell tumorsurvivaltreatment |
| spellingShingle | Sonay İncesoy-Özdemir Ulya Ertem Gürses Şahin Ceyhun Bozkurt Nazmiye Yüksek Ayşe Ceyda Ören Eda Balkaya Afra Alkan Clinical and epidemiological characteristics of children with germ cell tumors: A single center experience in a developing country The Turkish Journal of Pediatrics children germ cell tumor survival treatment |
| title | Clinical and epidemiological characteristics of children with germ cell tumors: A single center experience in a developing country |
| title_full | Clinical and epidemiological characteristics of children with germ cell tumors: A single center experience in a developing country |
| title_fullStr | Clinical and epidemiological characteristics of children with germ cell tumors: A single center experience in a developing country |
| title_full_unstemmed | Clinical and epidemiological characteristics of children with germ cell tumors: A single center experience in a developing country |
| title_short | Clinical and epidemiological characteristics of children with germ cell tumors: A single center experience in a developing country |
| title_sort | clinical and epidemiological characteristics of children with germ cell tumors a single center experience in a developing country |
| topic | children germ cell tumor survival treatment |
| url | https://turkjpediatr.org/article/view/1008 |
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