Insights into the Sources, Structure, and Action Mechanisms of Quinones on Diabetes: A Review
Quinones, one of the oldest organic compounds, are of increasing interest due to their abundant presence in a wide range of natural sources and their remarkable biological activity. These compounds occur naturally in green leafy vegetables, fruits, herbs, animal and marine sources, and fermented pro...
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MDPI AG
2025-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/3/665 |
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| author | Tingting Zhang Mingyue Li Jingyang Lu Jia Wang Min Zhang Pharkphoom Panichayupakaranant Haixia Chen |
| author_facet | Tingting Zhang Mingyue Li Jingyang Lu Jia Wang Min Zhang Pharkphoom Panichayupakaranant Haixia Chen |
| author_sort | Tingting Zhang |
| collection | DOAJ |
| description | Quinones, one of the oldest organic compounds, are of increasing interest due to their abundant presence in a wide range of natural sources and their remarkable biological activity. These compounds occur naturally in green leafy vegetables, fruits, herbs, animal and marine sources, and fermented products, and have demonstrated promising potential for use in health interventions, particularly in the prevention and management of type 2 diabetes (T2DM). This review aims to investigate the potential of quinones as a health intervention for T2DM from the multidimensional perspective of their sources, types, structure–activity relationship, glucose-lowering mechanism, toxicity reduction, and bioavailability enhancement. Emerging research highlights the hypoglycemic activities of quinones, mainly driven by their redox properties, which lead to covalent binding, and their structural substituent specificity, which leads to their non-covalent binding to biocomplexes. Quinones can improve insulin resistance and regulate glucose homeostasis by modulating mitochondrial function, inflammation, lipid profile, gastrointestinal absorption, and by acting as insulin mimetics. Meanwhile, increasing attention is being given to research focused on mitigating the toxicity of quinones during administration and enhancing their bioavailability. This review offers a critical foundation for the development of quinone-based health therapies and functional foods aimed at diabetes management. |
| format | Article |
| id | doaj-art-c0e0478809f4485eb6d12e02a867b799 |
| institution | DOAJ |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-c0e0478809f4485eb6d12e02a867b7992025-08-20T02:48:10ZengMDPI AGMolecules1420-30492025-02-0130366510.3390/molecules30030665Insights into the Sources, Structure, and Action Mechanisms of Quinones on Diabetes: A ReviewTingting Zhang0Mingyue Li1Jingyang Lu2Jia Wang3Min Zhang4Pharkphoom Panichayupakaranant5Haixia Chen6Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, ChinaTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, ChinaTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, ChinaTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, ChinaChina-Russia Agricultural Processing Joint Laboratory, Tianjin Agricultural University, Tianjin 300384, ChinaPhytomedicine and Pharmaceutical Biotechnology Excellence Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90112, ThailandTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, ChinaQuinones, one of the oldest organic compounds, are of increasing interest due to their abundant presence in a wide range of natural sources and their remarkable biological activity. These compounds occur naturally in green leafy vegetables, fruits, herbs, animal and marine sources, and fermented products, and have demonstrated promising potential for use in health interventions, particularly in the prevention and management of type 2 diabetes (T2DM). This review aims to investigate the potential of quinones as a health intervention for T2DM from the multidimensional perspective of their sources, types, structure–activity relationship, glucose-lowering mechanism, toxicity reduction, and bioavailability enhancement. Emerging research highlights the hypoglycemic activities of quinones, mainly driven by their redox properties, which lead to covalent binding, and their structural substituent specificity, which leads to their non-covalent binding to biocomplexes. Quinones can improve insulin resistance and regulate glucose homeostasis by modulating mitochondrial function, inflammation, lipid profile, gastrointestinal absorption, and by acting as insulin mimetics. Meanwhile, increasing attention is being given to research focused on mitigating the toxicity of quinones during administration and enhancing their bioavailability. This review offers a critical foundation for the development of quinone-based health therapies and functional foods aimed at diabetes management.https://www.mdpi.com/1420-3049/30/3/665quinonessourcestypesantidiabetic effectsstructure–activity relationshipactivity mechanism |
| spellingShingle | Tingting Zhang Mingyue Li Jingyang Lu Jia Wang Min Zhang Pharkphoom Panichayupakaranant Haixia Chen Insights into the Sources, Structure, and Action Mechanisms of Quinones on Diabetes: A Review Molecules quinones sources types antidiabetic effects structure–activity relationship activity mechanism |
| title | Insights into the Sources, Structure, and Action Mechanisms of Quinones on Diabetes: A Review |
| title_full | Insights into the Sources, Structure, and Action Mechanisms of Quinones on Diabetes: A Review |
| title_fullStr | Insights into the Sources, Structure, and Action Mechanisms of Quinones on Diabetes: A Review |
| title_full_unstemmed | Insights into the Sources, Structure, and Action Mechanisms of Quinones on Diabetes: A Review |
| title_short | Insights into the Sources, Structure, and Action Mechanisms of Quinones on Diabetes: A Review |
| title_sort | insights into the sources structure and action mechanisms of quinones on diabetes a review |
| topic | quinones sources types antidiabetic effects structure–activity relationship activity mechanism |
| url | https://www.mdpi.com/1420-3049/30/3/665 |
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