Brain Characteristics in Patients With Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disorder by 7.0 Tesla MRI
ABSTRACT Background Myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) can radiographically mimic multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). The disease hallmarks cortical lesion, central vein sign (CVS) and paramagnetic rim lesions identified in...
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Wiley
2025-07-01
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| Series: | Annals of Clinical and Translational Neurology |
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| Online Access: | https://doi.org/10.1002/acn3.70080 |
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| author | Lei Su Joseph Kuchling Chenyang Gao Thoralf Niendorf Carsten Finke Zhe Zhang Ai Guo Jing Jing De‐Cai Tian Yu‐Jing Li Mengting Zhang Xiaoyu Shi Xinyao Liu Huabing Wang Yaou Liu Claudia Chien Michael Levy Yunyun Duan Friedemann Paul Fu‐Dong Shi |
| author_facet | Lei Su Joseph Kuchling Chenyang Gao Thoralf Niendorf Carsten Finke Zhe Zhang Ai Guo Jing Jing De‐Cai Tian Yu‐Jing Li Mengting Zhang Xiaoyu Shi Xinyao Liu Huabing Wang Yaou Liu Claudia Chien Michael Levy Yunyun Duan Friedemann Paul Fu‐Dong Shi |
| author_sort | Lei Su |
| collection | DOAJ |
| description | ABSTRACT Background Myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) can radiographically mimic multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). The disease hallmarks cortical lesion, central vein sign (CVS) and paramagnetic rim lesions identified in MS have not yet been comprehensively investigated in MOGAD. Methods We have characterized 45 patients with MOGAD using 7.0 Tesla (7 T) MRI at two academic research hospitals in China and Germany. 7 T MRI, laboratory, and clinical data were collected. The classification of cortical lesions, proportion of CVS, and the phase shifts of lesions on susceptibility weighted imaging were analyzed. Results Of the 45 patients enrolled with MOGAD, 282 lesions were identified. We further detected 31 (11%) cortical lesions including leukocortical, intracortical, and subpial types, of which intracortical lesions (16/31, 52%) were frequently involved. CVS was identified in 53 (19%) lesions of 21 (47%) patients, 154 (55%) lesions showed multiple veins sign (MVS) in 30 (67%) patients. The number (4.3 ± 6.0 vs. 1.5 ± 2.1, p = 0.0049) and percentage (52% vs. 18%, p < 0.0001) of MVS lesions for each MOGAD patient were higher than those of CVS. Eight patients (18%) had 39 (14%) lesions of hypointense signal with paramagnetic phase shifts on SWI, showing nodular phase changes and irregular borders in appearance. Conclusions In our observational MOGAD cohort, all three types of cortical lesions were recognized, with intracortical lesions being the most common. The number and proportion of lesions with MVS were higher than those with CVS. Lesions with paramagnetic phase changes were rare and non‐rim‐like in appearance. These findings provide a better understanding of the underlying pathology of MOGAD and will help in the differentiation of MOGAD from other demyelinating disorders. |
| format | Article |
| id | doaj-art-c0d9a01de11f4906bf64c2f586929380 |
| institution | DOAJ |
| issn | 2328-9503 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
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| series | Annals of Clinical and Translational Neurology |
| spelling | doaj-art-c0d9a01de11f4906bf64c2f5869293802025-08-20T03:11:39ZengWileyAnnals of Clinical and Translational Neurology2328-95032025-07-011271431144110.1002/acn3.70080Brain Characteristics in Patients With Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disorder by 7.0 Tesla MRILei Su0Joseph Kuchling1Chenyang Gao2Thoralf Niendorf3Carsten Finke4Zhe Zhang5Ai Guo6Jing Jing7De‐Cai Tian8Yu‐Jing Li9Mengting Zhang10Xiaoyu Shi11Xinyao Liu12Huabing Wang13Yaou Liu14Claudia Chien15Michael Levy16Yunyun Duan17Friedemann Paul18Fu‐Dong Shi19Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaExperimental and Clinical Research Center Max Delbrueck Center for Molecular Medicine, Charité Universitätsmedizin Berlin Berlin GermanyTiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaExperimental and Clinical Research Center Max Delbrueck Center for Molecular Medicine, Charité Universitätsmedizin Berlin Berlin GermanyExperimental and Clinical Research Center Max Delbrueck Center for Molecular Medicine, Charité Universitätsmedizin Berlin Berlin GermanyTiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaTiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaTiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaTiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Neurology Tianjin Medical University General Hospital Tianjin ChinaTiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaTiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaTiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaTiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Radiology, Beijing Tiantan Hospital Capital Medical University Beijing ChinaExperimental and Clinical Research Center Max Delbrueck Center for Molecular Medicine, Charité Universitätsmedizin Berlin Berlin GermanyDepartment of Neurology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USADepartment of Radiology, Beijing Tiantan Hospital Capital Medical University Beijing ChinaExperimental and Clinical Research Center Max Delbrueck Center for Molecular Medicine, Charité Universitätsmedizin Berlin Berlin GermanyTiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing ChinaABSTRACT Background Myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) can radiographically mimic multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). The disease hallmarks cortical lesion, central vein sign (CVS) and paramagnetic rim lesions identified in MS have not yet been comprehensively investigated in MOGAD. Methods We have characterized 45 patients with MOGAD using 7.0 Tesla (7 T) MRI at two academic research hospitals in China and Germany. 7 T MRI, laboratory, and clinical data were collected. The classification of cortical lesions, proportion of CVS, and the phase shifts of lesions on susceptibility weighted imaging were analyzed. Results Of the 45 patients enrolled with MOGAD, 282 lesions were identified. We further detected 31 (11%) cortical lesions including leukocortical, intracortical, and subpial types, of which intracortical lesions (16/31, 52%) were frequently involved. CVS was identified in 53 (19%) lesions of 21 (47%) patients, 154 (55%) lesions showed multiple veins sign (MVS) in 30 (67%) patients. The number (4.3 ± 6.0 vs. 1.5 ± 2.1, p = 0.0049) and percentage (52% vs. 18%, p < 0.0001) of MVS lesions for each MOGAD patient were higher than those of CVS. Eight patients (18%) had 39 (14%) lesions of hypointense signal with paramagnetic phase shifts on SWI, showing nodular phase changes and irregular borders in appearance. Conclusions In our observational MOGAD cohort, all three types of cortical lesions were recognized, with intracortical lesions being the most common. The number and proportion of lesions with MVS were higher than those with CVS. Lesions with paramagnetic phase changes were rare and non‐rim‐like in appearance. These findings provide a better understanding of the underlying pathology of MOGAD and will help in the differentiation of MOGAD from other demyelinating disorders.https://doi.org/10.1002/acn3.700807 T MRIcentral vein signcortical lesionmyelin oligodendrocyte glycoproteinparamagnetic rim lesion |
| spellingShingle | Lei Su Joseph Kuchling Chenyang Gao Thoralf Niendorf Carsten Finke Zhe Zhang Ai Guo Jing Jing De‐Cai Tian Yu‐Jing Li Mengting Zhang Xiaoyu Shi Xinyao Liu Huabing Wang Yaou Liu Claudia Chien Michael Levy Yunyun Duan Friedemann Paul Fu‐Dong Shi Brain Characteristics in Patients With Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disorder by 7.0 Tesla MRI Annals of Clinical and Translational Neurology 7 T MRI central vein sign cortical lesion myelin oligodendrocyte glycoprotein paramagnetic rim lesion |
| title | Brain Characteristics in Patients With Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disorder by 7.0 Tesla MRI |
| title_full | Brain Characteristics in Patients With Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disorder by 7.0 Tesla MRI |
| title_fullStr | Brain Characteristics in Patients With Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disorder by 7.0 Tesla MRI |
| title_full_unstemmed | Brain Characteristics in Patients With Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disorder by 7.0 Tesla MRI |
| title_short | Brain Characteristics in Patients With Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disorder by 7.0 Tesla MRI |
| title_sort | brain characteristics in patients with myelin oligodendrocyte glycoprotein antibody associated disorder by 7 0 tesla mri |
| topic | 7 T MRI central vein sign cortical lesion myelin oligodendrocyte glycoprotein paramagnetic rim lesion |
| url | https://doi.org/10.1002/acn3.70080 |
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