Long term clinical outcomes in patients with rectal adenocarcinoma treated at a Tertiary Care Centre in South India
Introduction: Treatment of rectal adenocarcinoma involves multi-disciplinary approach which includes radiation, surgery and chemotherapy. Our study aims to assess the clinical outcomes of patients with rectal adenocarcinoma treated in a tertiary care centre in South India. Materials and methods: A...
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Zabansaraye Parsian Novin Mehr Institute
2025-06-01
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| Series: | Journal of Current Oncology and Medical Sciences |
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| Online Access: | https://submission.journalofcoms.com/index.php/JCOMS/article/view/343 |
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| author | Amirthvarshan A Lijeesh A L Roshni S Mulla P A Sivanandan C D Sajeed A Arun Sankar Geethi M H Aleyamma Mathew |
| author_facet | Amirthvarshan A Lijeesh A L Roshni S Mulla P A Sivanandan C D Sajeed A Arun Sankar Geethi M H Aleyamma Mathew |
| author_sort | Amirthvarshan A |
| collection | DOAJ |
| description | Introduction: Treatment of rectal adenocarcinoma involves multi-disciplinary approach which includes radiation, surgery and chemotherapy. Our study aims to assess the clinical outcomes of patients with rectal adenocarcinoma treated in a tertiary care centre in South India.
Materials and methods: A retrospective content-based analysis was made of 131 patients diagnosed and treated for adenocarcinoma rectum in a tertiary care hospital during the period of 1st January 2014 to 31st December 2015. The primary objectives were to assess disease‑free survival (DFS) and overall survival (OS).
Results: Of the 131 patients, 82 were males and 49 were females with a median age of 59 years. Stage II and Stage III disease together contributed to 65.6% of study population. After a median follow up of 105.8 months, the 8-year overall survival (OS) and disease-free survival (DFS) were found to be 77.2% and 78.8% respectively. In the univariate analysis, stage of the disease and histology were found to be significant factors in determining the overall survival (p<0.05). Multivariate analysis showed poorly differentiated adenocarcinoma emerged as significant factor affecting overall survival. About 31 (23.6%) patients showed disease recurrence. Of the 31 patients, pelvic recurrence occurred in 26% patients and among the distant metastases, liver was the most common site (33%) followed by lung (22%).
Conclusion: The disease free survival and overall survival of our patients were comparable with the available published data. |
| format | Article |
| id | doaj-art-c0cbfb7ed0284647a65253ea99dc355e |
| institution | DOAJ |
| issn | 2783-3127 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Zabansaraye Parsian Novin Mehr Institute |
| record_format | Article |
| series | Journal of Current Oncology and Medical Sciences |
| spelling | doaj-art-c0cbfb7ed0284647a65253ea99dc355e2025-08-20T03:13:22ZengZabansaraye Parsian Novin Mehr InstituteJournal of Current Oncology and Medical Sciences2783-31272025-06-015211681177Long term clinical outcomes in patients with rectal adenocarcinoma treated at a Tertiary Care Centre in South IndiaAmirthvarshan A 0Lijeesh A L 1Roshni S 2Mulla P A 3Sivanandan C D 4Sajeed A 5Arun Sankar 6Geethi M H 7Aleyamma Mathew 8Department of Radiation Oncology, Regional Cancer Centre, Thiruvananthapuram, IndiaDepartment of Radiation Oncology, Regional Cancer Centre, Thiruvananthapuram, IndiaDepartment of Radiation Oncology, Regional Cancer Centre, Thiruvananthapuram, IndiaDepartment of Radiation Oncology, Mangalore Institute of Oncology, Mangaluru, Karnataka, IndiaDepartment of Radiation Oncology, Regional Cancer Centre, Thiruvananthapuram, IndiaDepartment of Radiation Oncology, Regional Cancer Centre, Thiruvananthapuram, IndiaDepartment of Radiation Oncology, Regional Cancer Centre, Thiruvananthapuram, IndiaDepartment of Radiation Oncology, Regional Cancer Centre, Thiruvananthapuram, IndiaDivision of Cancer epidemiology and Biostatistics, Regional cancer Centre, Thiruvananthapuram, IndiaIntroduction: Treatment of rectal adenocarcinoma involves multi-disciplinary approach which includes radiation, surgery and chemotherapy. Our study aims to assess the clinical outcomes of patients with rectal adenocarcinoma treated in a tertiary care centre in South India. Materials and methods: A retrospective content-based analysis was made of 131 patients diagnosed and treated for adenocarcinoma rectum in a tertiary care hospital during the period of 1st January 2014 to 31st December 2015. The primary objectives were to assess disease‑free survival (DFS) and overall survival (OS). Results: Of the 131 patients, 82 were males and 49 were females with a median age of 59 years. Stage II and Stage III disease together contributed to 65.6% of study population. After a median follow up of 105.8 months, the 8-year overall survival (OS) and disease-free survival (DFS) were found to be 77.2% and 78.8% respectively. In the univariate analysis, stage of the disease and histology were found to be significant factors in determining the overall survival (p<0.05). Multivariate analysis showed poorly differentiated adenocarcinoma emerged as significant factor affecting overall survival. About 31 (23.6%) patients showed disease recurrence. Of the 31 patients, pelvic recurrence occurred in 26% patients and among the distant metastases, liver was the most common site (33%) followed by lung (22%). Conclusion: The disease free survival and overall survival of our patients were comparable with the available published data.https://submission.journalofcoms.com/index.php/JCOMS/article/view/343rectal cancerhistologyyoung adultssurvival ratesprognosis |
| spellingShingle | Amirthvarshan A Lijeesh A L Roshni S Mulla P A Sivanandan C D Sajeed A Arun Sankar Geethi M H Aleyamma Mathew Long term clinical outcomes in patients with rectal adenocarcinoma treated at a Tertiary Care Centre in South India Journal of Current Oncology and Medical Sciences rectal cancer histology young adults survival rates prognosis |
| title | Long term clinical outcomes in patients with rectal adenocarcinoma treated at a Tertiary Care Centre in South India |
| title_full | Long term clinical outcomes in patients with rectal adenocarcinoma treated at a Tertiary Care Centre in South India |
| title_fullStr | Long term clinical outcomes in patients with rectal adenocarcinoma treated at a Tertiary Care Centre in South India |
| title_full_unstemmed | Long term clinical outcomes in patients with rectal adenocarcinoma treated at a Tertiary Care Centre in South India |
| title_short | Long term clinical outcomes in patients with rectal adenocarcinoma treated at a Tertiary Care Centre in South India |
| title_sort | long term clinical outcomes in patients with rectal adenocarcinoma treated at a tertiary care centre in south india |
| topic | rectal cancer histology young adults survival rates prognosis |
| url | https://submission.journalofcoms.com/index.php/JCOMS/article/view/343 |
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