Severe Dental Disease as a Presenting Sign of Relapsed 6q24-Related Transient Neonatal Diabetes Mellitus
Transient neonatal diabetes mellitus (TNDM) is a rare form of diabetes that presents in infancy and is characterized by intrauterine growth restriction and hyperglycemia without ketones on urinalysis. Patients are treated with insulin until remission, usually within the first year. Relapse to a perm...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/8828516 |
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| author | Anna Delamerced Lauren J. Massingham Jose Bernardo Quintos |
| author_facet | Anna Delamerced Lauren J. Massingham Jose Bernardo Quintos |
| author_sort | Anna Delamerced |
| collection | DOAJ |
| description | Transient neonatal diabetes mellitus (TNDM) is a rare form of diabetes that presents in infancy and is characterized by intrauterine growth restriction and hyperglycemia without ketones on urinalysis. Patients are treated with insulin until remission, usually within the first year. Relapse to a permanent state may occur later in life, with a mean age of 14 years. The most common cause of TNDM is a chromosome 6q24 mutation that affects pancreatic β-cell function. Reports of relapse have been limited. We describe a case of an adolescent female with TNDM due to 6q24 hypomethylation who relapsed at 15 years of age with severe dental disease as the presenting sign. |
| format | Article |
| id | doaj-art-c0cbb425100449889ab68b8dd4c98c86 |
| institution | DOAJ |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-c0cbb425100449889ab68b8dd4c98c862025-08-20T03:23:26ZengWileyCase Reports in Endocrinology2090-65012090-651X2020-01-01202010.1155/2020/88285168828516Severe Dental Disease as a Presenting Sign of Relapsed 6q24-Related Transient Neonatal Diabetes MellitusAnna Delamerced0Lauren J. Massingham1Jose Bernardo Quintos2The Warren Alpert Medical School of Brown University, Providence, RI, USAThe Warren Alpert Medical School of Brown University, Rhode Island Hospital, Hasbro Children’s Hospital, 593 Eddy Street, Providence, Rhode Island 02903, USAThe Warren Alpert Medical School of Brown University, Rhode Island Hospital, Hasbro Children’s Hospital, 593 Eddy Street, Providence, Rhode Island 02903, USATransient neonatal diabetes mellitus (TNDM) is a rare form of diabetes that presents in infancy and is characterized by intrauterine growth restriction and hyperglycemia without ketones on urinalysis. Patients are treated with insulin until remission, usually within the first year. Relapse to a permanent state may occur later in life, with a mean age of 14 years. The most common cause of TNDM is a chromosome 6q24 mutation that affects pancreatic β-cell function. Reports of relapse have been limited. We describe a case of an adolescent female with TNDM due to 6q24 hypomethylation who relapsed at 15 years of age with severe dental disease as the presenting sign.http://dx.doi.org/10.1155/2020/8828516 |
| spellingShingle | Anna Delamerced Lauren J. Massingham Jose Bernardo Quintos Severe Dental Disease as a Presenting Sign of Relapsed 6q24-Related Transient Neonatal Diabetes Mellitus Case Reports in Endocrinology |
| title | Severe Dental Disease as a Presenting Sign of Relapsed 6q24-Related Transient Neonatal Diabetes Mellitus |
| title_full | Severe Dental Disease as a Presenting Sign of Relapsed 6q24-Related Transient Neonatal Diabetes Mellitus |
| title_fullStr | Severe Dental Disease as a Presenting Sign of Relapsed 6q24-Related Transient Neonatal Diabetes Mellitus |
| title_full_unstemmed | Severe Dental Disease as a Presenting Sign of Relapsed 6q24-Related Transient Neonatal Diabetes Mellitus |
| title_short | Severe Dental Disease as a Presenting Sign of Relapsed 6q24-Related Transient Neonatal Diabetes Mellitus |
| title_sort | severe dental disease as a presenting sign of relapsed 6q24 related transient neonatal diabetes mellitus |
| url | http://dx.doi.org/10.1155/2020/8828516 |
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