Response to Initial Therapy of Differentiated Thyroid Cancer Predicts the Long-Term Outcome Better than Classical Risk Stratification Systems
Objective. Although differentiated thyroid cancer (DTC) usually has an indolent course, some cases show a poor prognosis; therefore, risk stratification is required. The objective of this study is to compare the predictive ability of classical risk stratification systems proposed by the European Thy...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/591285 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558685632593920 |
|---|---|
| author | Albert Cano-Palomares Ignasi Castells Ismael Capel Maria Rosa Bella Santi Barcons Angel Serrano Xavier Guirao Mercedes Rigla |
| author_facet | Albert Cano-Palomares Ignasi Castells Ismael Capel Maria Rosa Bella Santi Barcons Angel Serrano Xavier Guirao Mercedes Rigla |
| author_sort | Albert Cano-Palomares |
| collection | DOAJ |
| description | Objective. Although differentiated thyroid cancer (DTC) usually has an indolent course, some cases show a poor prognosis; therefore, risk stratification is required. The objective of this study is to compare the predictive ability of classical risk stratification systems proposed by the European Thyroid Association (ETA) and American Thyroid Association (ATA) with the system proposed by Tuttle et al. in 2010, based on the response to initial therapy (RIT). Methods. We retrospectively reviewed 176 cases of DTC with a median follow-up period of 7.0 years. Each patient was stratified using ETA, ATA, and RIT systems. Negative predictive value (NPV) and positive predictive value (PPV) were determined. The area under receiver operating characteristic (ROC) curve was calculated in order to compare the predictive ability. Results. RIT showed a NPV of 97.7%, better than NPV of ETA and ATA systems (93.9% and 94.9%, resp.). ETA and ATA systems showed poor PPV (40.3% and 41%, resp.), while RIT showed a PPV of 70.8%. The area under ROC curve was 0.7535 for ETA, 0.7876 for ATA, and 0.9112 for RIT, showing statistical significant differences P<0.05. Conclusions. RIT predicts the long-term outcome of DTC better than ETA/ATA systems, becoming a useful system to adapt management strategies. |
| format | Article |
| id | doaj-art-c0cb8231479d421692b739907cfdd675 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-c0cb8231479d421692b739907cfdd6752025-02-03T01:31:52ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/591285591285Response to Initial Therapy of Differentiated Thyroid Cancer Predicts the Long-Term Outcome Better than Classical Risk Stratification SystemsAlbert Cano-Palomares0Ignasi Castells1Ismael Capel2Maria Rosa Bella3Santi Barcons4Angel Serrano5Xavier Guirao6Mercedes Rigla7Endocrinology and Nutrition Department, Parc Taulí Sabadell University Hospital, Parc Taulí s/n, Sabadell, 08208 Barcelona, SpainEndocrinology, Diabetes and Nutrition Unit, Granollers General Hospital, Francesc Ribas s/n, Granollers, 08402 Barcelona, SpainEndocrinology and Nutrition Department, Parc Taulí Sabadell University Hospital, Parc Taulí s/n, Sabadell, 08208 Barcelona, SpainPathology Department, Parc Taulí Sabadell University Hospital, Sabadell, Barcelona, SpainSurgery Department, Parc Taulí Sabadell University Hospital, Sabadell, Barcelona, SpainUniversitat Internacional de Catalunya (UIC), Josep Trueta s/n, Sant Cugat, 08195 Barcelona, SpainUniversitat Internacional de Catalunya (UIC), Josep Trueta s/n, Sant Cugat, 08195 Barcelona, SpainEndocrinology and Nutrition Department, Parc Taulí Sabadell University Hospital, Parc Taulí s/n, Sabadell, 08208 Barcelona, SpainObjective. Although differentiated thyroid cancer (DTC) usually has an indolent course, some cases show a poor prognosis; therefore, risk stratification is required. The objective of this study is to compare the predictive ability of classical risk stratification systems proposed by the European Thyroid Association (ETA) and American Thyroid Association (ATA) with the system proposed by Tuttle et al. in 2010, based on the response to initial therapy (RIT). Methods. We retrospectively reviewed 176 cases of DTC with a median follow-up period of 7.0 years. Each patient was stratified using ETA, ATA, and RIT systems. Negative predictive value (NPV) and positive predictive value (PPV) were determined. The area under receiver operating characteristic (ROC) curve was calculated in order to compare the predictive ability. Results. RIT showed a NPV of 97.7%, better than NPV of ETA and ATA systems (93.9% and 94.9%, resp.). ETA and ATA systems showed poor PPV (40.3% and 41%, resp.), while RIT showed a PPV of 70.8%. The area under ROC curve was 0.7535 for ETA, 0.7876 for ATA, and 0.9112 for RIT, showing statistical significant differences P<0.05. Conclusions. RIT predicts the long-term outcome of DTC better than ETA/ATA systems, becoming a useful system to adapt management strategies.http://dx.doi.org/10.1155/2014/591285 |
| spellingShingle | Albert Cano-Palomares Ignasi Castells Ismael Capel Maria Rosa Bella Santi Barcons Angel Serrano Xavier Guirao Mercedes Rigla Response to Initial Therapy of Differentiated Thyroid Cancer Predicts the Long-Term Outcome Better than Classical Risk Stratification Systems International Journal of Endocrinology |
| title | Response to Initial Therapy of Differentiated Thyroid Cancer Predicts the Long-Term Outcome Better than Classical Risk Stratification Systems |
| title_full | Response to Initial Therapy of Differentiated Thyroid Cancer Predicts the Long-Term Outcome Better than Classical Risk Stratification Systems |
| title_fullStr | Response to Initial Therapy of Differentiated Thyroid Cancer Predicts the Long-Term Outcome Better than Classical Risk Stratification Systems |
| title_full_unstemmed | Response to Initial Therapy of Differentiated Thyroid Cancer Predicts the Long-Term Outcome Better than Classical Risk Stratification Systems |
| title_short | Response to Initial Therapy of Differentiated Thyroid Cancer Predicts the Long-Term Outcome Better than Classical Risk Stratification Systems |
| title_sort | response to initial therapy of differentiated thyroid cancer predicts the long term outcome better than classical risk stratification systems |
| url | http://dx.doi.org/10.1155/2014/591285 |
| work_keys_str_mv | AT albertcanopalomares responsetoinitialtherapyofdifferentiatedthyroidcancerpredictsthelongtermoutcomebetterthanclassicalriskstratificationsystems AT ignasicastells responsetoinitialtherapyofdifferentiatedthyroidcancerpredictsthelongtermoutcomebetterthanclassicalriskstratificationsystems AT ismaelcapel responsetoinitialtherapyofdifferentiatedthyroidcancerpredictsthelongtermoutcomebetterthanclassicalriskstratificationsystems AT mariarosabella responsetoinitialtherapyofdifferentiatedthyroidcancerpredictsthelongtermoutcomebetterthanclassicalriskstratificationsystems AT santibarcons responsetoinitialtherapyofdifferentiatedthyroidcancerpredictsthelongtermoutcomebetterthanclassicalriskstratificationsystems AT angelserrano responsetoinitialtherapyofdifferentiatedthyroidcancerpredictsthelongtermoutcomebetterthanclassicalriskstratificationsystems AT xavierguirao responsetoinitialtherapyofdifferentiatedthyroidcancerpredictsthelongtermoutcomebetterthanclassicalriskstratificationsystems AT mercedesrigla responsetoinitialtherapyofdifferentiatedthyroidcancerpredictsthelongtermoutcomebetterthanclassicalriskstratificationsystems |