18-Fluorodeoxyglucose Uptake by Positron Emission Tomography in Extraocular Muscles of Patients with and without Graves' Ophthalmology
Objective. To compare 18-fluorodeoxyglucose (FDG) uptake by positron emission tomography (PET) in extraocular muscles (EOMs) of patients with Graves’ ophthalmopathy (GO) versus patients without GO. Design. Prospective, observational, comparative, and cross-sectional study....
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2013/529187 |
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| author | Leonardo García-Rojas Gloria Adame-Ocampo Erick Alexánderson José Luis Tovilla-Canales |
| author_facet | Leonardo García-Rojas Gloria Adame-Ocampo Erick Alexánderson José Luis Tovilla-Canales |
| author_sort | Leonardo García-Rojas |
| collection | DOAJ |
| description | Objective. To compare 18-fluorodeoxyglucose (FDG) uptake by positron emission tomography (PET) in extraocular muscles (EOMs) of patients with Graves’ ophthalmopathy (GO) versus patients without GO.
Design. Prospective, observational, comparative, and cross-sectional study.
Participants. Thirty-two eyes of patients with GO and seventy eyes of patients without GO.
Methods. We prospectively included patients older than 18 years of age with and without GO. FDG-PET imaging study was performed; standardized unit value () was quantified in EOMs. Standard deviation and significant statistical difference () were calculated. Results. Thirty-two eyes of sixteen patients of the GO group were included, with a mean age of 44.31 (20–71) years. Seventy eyes of thirty-five patients of the group without GO were included,
with a mean age of 49.20 (24–77) years. EOMs average uptake of the groups with and without GO were 3.38 ± 1.31 and 1.89 ± 0.51 (), respectively. Conclusion. FDG uptake was significantly increased in EOMs of patients with GO. PET gives valuable information and may be a helpful tool in detecting, localizing, and quantifying GO inflammation. Further research is needed to define the role of PET in detecting, grading, and following up GO in order to optimize treatment in the inflammatory stage. |
| format | Article |
| id | doaj-art-c0c6495192124677b4d4544cb1cc3854 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-c0c6495192124677b4d4544cb1cc38542025-02-03T05:47:51ZengWileyJournal of Ophthalmology2090-004X2090-00582013-01-01201310.1155/2013/52918752918718-Fluorodeoxyglucose Uptake by Positron Emission Tomography in Extraocular Muscles of Patients with and without Graves' OphthalmologyLeonardo García-Rojas0Gloria Adame-Ocampo1Erick Alexánderson2José Luis Tovilla-Canales3Instituto de Oftalmología “Fundación de Asistencia Privada Conde de Valenciana I.A.P.”, 06800 Mexico City, DF, MexicoUnidad PET/CT Ciclotrón, Facultad de Medicina, Universidad Nacional Autónoma de México, 04510 Mexico City, DF, MexicoUnidad PET/CT Ciclotrón, Facultad de Medicina, Universidad Nacional Autónoma de México, 04510 Mexico City, DF, MexicoInstituto de Oftalmología “Fundación de Asistencia Privada Conde de Valenciana I.A.P.”, 06800 Mexico City, DF, MexicoObjective. To compare 18-fluorodeoxyglucose (FDG) uptake by positron emission tomography (PET) in extraocular muscles (EOMs) of patients with Graves’ ophthalmopathy (GO) versus patients without GO. Design. Prospective, observational, comparative, and cross-sectional study. Participants. Thirty-two eyes of patients with GO and seventy eyes of patients without GO. Methods. We prospectively included patients older than 18 years of age with and without GO. FDG-PET imaging study was performed; standardized unit value () was quantified in EOMs. Standard deviation and significant statistical difference () were calculated. Results. Thirty-two eyes of sixteen patients of the GO group were included, with a mean age of 44.31 (20–71) years. Seventy eyes of thirty-five patients of the group without GO were included, with a mean age of 49.20 (24–77) years. EOMs average uptake of the groups with and without GO were 3.38 ± 1.31 and 1.89 ± 0.51 (), respectively. Conclusion. FDG uptake was significantly increased in EOMs of patients with GO. PET gives valuable information and may be a helpful tool in detecting, localizing, and quantifying GO inflammation. Further research is needed to define the role of PET in detecting, grading, and following up GO in order to optimize treatment in the inflammatory stage.http://dx.doi.org/10.1155/2013/529187 |
| spellingShingle | Leonardo García-Rojas Gloria Adame-Ocampo Erick Alexánderson José Luis Tovilla-Canales 18-Fluorodeoxyglucose Uptake by Positron Emission Tomography in Extraocular Muscles of Patients with and without Graves' Ophthalmology Journal of Ophthalmology |
| title | 18-Fluorodeoxyglucose Uptake by Positron Emission Tomography in Extraocular Muscles of Patients with and without Graves' Ophthalmology |
| title_full | 18-Fluorodeoxyglucose Uptake by Positron Emission Tomography in Extraocular Muscles of Patients with and without Graves' Ophthalmology |
| title_fullStr | 18-Fluorodeoxyglucose Uptake by Positron Emission Tomography in Extraocular Muscles of Patients with and without Graves' Ophthalmology |
| title_full_unstemmed | 18-Fluorodeoxyglucose Uptake by Positron Emission Tomography in Extraocular Muscles of Patients with and without Graves' Ophthalmology |
| title_short | 18-Fluorodeoxyglucose Uptake by Positron Emission Tomography in Extraocular Muscles of Patients with and without Graves' Ophthalmology |
| title_sort | 18 fluorodeoxyglucose uptake by positron emission tomography in extraocular muscles of patients with and without graves ophthalmology |
| url | http://dx.doi.org/10.1155/2013/529187 |
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