Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis

Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis

Abstract Neuropathic pain, a debilitating nerve injury-induced condition, remains a significant clinical challenge. This study evaluates the effect of histone deacetylase 6 (HDAC6) inhibition in a spared nerve injury (SNI) mouse model. Systemic administration of the selective HDAC6 inhibitor ACY-121...

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Main Authors: Zhexi Chi, Bo Lu, Rongjun Liu, Chen Pan, Bo Meng, Xiuzhong Xing, Hui Yuan, Xuewei Wu, Yushan Chen, Yuxuan Ren, Wenwei Wu, Mengmeng Miao, Junping Chen, Xiaowei Chen
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Neuroinflammation
Subjects:
Neuropathic pain
HDAC6
ACY-1215
STAT3
CCL7
Online Access:https://doi.org/10.1186/s12974-025-03400-y
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