Research progress of microglial surface receptors in perioperative neurocognitive disorders
Abstract Perioperative neurocognitive disorder (PND) is a common complication in the perioperative period, which not only prolongs the hospitalization of patients, increases the cost of treatment, but even increases the postoperative mortality of patients, bringing a heavy burden to families and soc...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2024-12-01
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| Series: | Ibrain |
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| Online Access: | https://doi.org/10.1002/ibra.12136 |
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| author | Chun‐Chun Tang De‐Xing Liu Zhao‐Qiong Zhu |
| author_facet | Chun‐Chun Tang De‐Xing Liu Zhao‐Qiong Zhu |
| author_sort | Chun‐Chun Tang |
| collection | DOAJ |
| description | Abstract Perioperative neurocognitive disorder (PND) is a common complication in the perioperative period, which not only prolongs the hospitalization of patients, increases the cost of treatment, but even increases the postoperative mortality of patients, bringing a heavy burden to families and society. Mechanism exploration involves anesthesia and surgery that lead to microglial activation, promote the synthesis and secretion of inflammatory factors, cause an inflammatory cascade, aggravate nerve cell damage, and lead to cognitive dysfunction. It is believed that microglia‐mediated neuroinflammatory responses play a vital role in the formation of PND. Microglia surface receptors are essential mediators for microglia to receive external stimuli, regulate microglial functional status, and carry out intercellular signal transmission. Various microglial surface receptors trigger neuroinflammation, damage neurons, and participate in the development and progression of PND by activating microglia. In this study, the roles of immunoglobulin receptors, chemokine receptors, purinergic receptors, and pattern recognition receptors in microglia surface receptors in PND were reviewed, to provide a reference for the mechanism research, prevention, and treatment of PND. |
| format | Article |
| id | doaj-art-c0c2e030eeee4f11b0faa6328d10fa9c |
| institution | OA Journals |
| issn | 2313-1934 2769-2795 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Ibrain |
| spelling | doaj-art-c0c2e030eeee4f11b0faa6328d10fa9c2025-08-20T01:58:27ZengWiley-VCHIbrain2313-19342769-27952024-12-0110445046110.1002/ibra.12136Research progress of microglial surface receptors in perioperative neurocognitive disordersChun‐Chun Tang0De‐Xing Liu1Zhao‐Qiong Zhu2Department of Anesthesiology Affiliated Hospital of Zunyi Medical University Zunyi Guizhou ChinaDepartment of Anesthesiology Affiliated Hospital of Zunyi Medical University Zunyi Guizhou ChinaDepartment of Anesthesiology Affiliated Hospital of Zunyi Medical University Zunyi Guizhou ChinaAbstract Perioperative neurocognitive disorder (PND) is a common complication in the perioperative period, which not only prolongs the hospitalization of patients, increases the cost of treatment, but even increases the postoperative mortality of patients, bringing a heavy burden to families and society. Mechanism exploration involves anesthesia and surgery that lead to microglial activation, promote the synthesis and secretion of inflammatory factors, cause an inflammatory cascade, aggravate nerve cell damage, and lead to cognitive dysfunction. It is believed that microglia‐mediated neuroinflammatory responses play a vital role in the formation of PND. Microglia surface receptors are essential mediators for microglia to receive external stimuli, regulate microglial functional status, and carry out intercellular signal transmission. Various microglial surface receptors trigger neuroinflammation, damage neurons, and participate in the development and progression of PND by activating microglia. In this study, the roles of immunoglobulin receptors, chemokine receptors, purinergic receptors, and pattern recognition receptors in microglia surface receptors in PND were reviewed, to provide a reference for the mechanism research, prevention, and treatment of PND.https://doi.org/10.1002/ibra.12136cell surface receptorsmicroglianeuroinflammatoryperioperative neurocognitive disorders |
| spellingShingle | Chun‐Chun Tang De‐Xing Liu Zhao‐Qiong Zhu Research progress of microglial surface receptors in perioperative neurocognitive disorders Ibrain cell surface receptors microglia neuroinflammatory perioperative neurocognitive disorders |
| title | Research progress of microglial surface receptors in perioperative neurocognitive disorders |
| title_full | Research progress of microglial surface receptors in perioperative neurocognitive disorders |
| title_fullStr | Research progress of microglial surface receptors in perioperative neurocognitive disorders |
| title_full_unstemmed | Research progress of microglial surface receptors in perioperative neurocognitive disorders |
| title_short | Research progress of microglial surface receptors in perioperative neurocognitive disorders |
| title_sort | research progress of microglial surface receptors in perioperative neurocognitive disorders |
| topic | cell surface receptors microglia neuroinflammatory perioperative neurocognitive disorders |
| url | https://doi.org/10.1002/ibra.12136 |
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