The role and diagnostic value of deregulated miRNAs in cervical cancer
Abstract Cervical cancer (CC) remains a significant global health concern, particularly affecting women in low-income countries. Despite advancements in screening programs, CC continues to pose a substantial mortality risk, highlighting the need to explore diagnostic and treatment modalities. This r...
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| Format: | Article |
| Language: | English |
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Springer
2025-05-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-02744-4 |
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| author | Masoumeh Parvizi Maryam Vaezi Farhad Jeddi Masoumeh Bakhshandeh Reza Eghdam-Zamiri Noushin Mobaraki-Asl Ebrahim Esmati Abbas Karimi |
| author_facet | Masoumeh Parvizi Maryam Vaezi Farhad Jeddi Masoumeh Bakhshandeh Reza Eghdam-Zamiri Noushin Mobaraki-Asl Ebrahim Esmati Abbas Karimi |
| author_sort | Masoumeh Parvizi |
| collection | DOAJ |
| description | Abstract Cervical cancer (CC) remains a significant global health concern, particularly affecting women in low-income countries. Despite advancements in screening programs, CC continues to pose a substantial mortality risk, highlighting the need to explore diagnostic and treatment modalities. This review focuses on the role of deregulated microRNAs (miRNAs) in CC development, emphasizing their potential as biomarkers for early detection and prognosis in body fluids. miRNAs have emerged as critical regulators of key cellular processes, including proliferation, migration, invasion, and apoptosis, and their dysregulation is closely linked to CC progression. Upregulated miRNAs such as miR-146b-3p, miR-1908, and miR-21 promote CC progression by targeting tumor suppressor genes, while downregulated miRNAs like miR-23-3p and miR-4262 are associated with reduced tumor aggressiveness. miRNAs also hold significant promise as non-invasive prognostic biomarkers. Their expression levels correlate with clinical outcomes, including tumor stage, metastasis, and overall survival, making them valuable tools for risk stratification and personalized treatment strategies. Liquid biopsies, which detect circulating miRNAs in bodily fluids, offer a minimally invasive approach to monitor tumor dynamics and predict patient outcomes. Furthermore, exosomal miRNAs are emerging as promising diagnostic and prognostic tools for CC. Advanced diagnostic technologies and bioinformatics tools are anticipated to enhance the identification of evident miRNA biomarkers in the clinical settings. Standardized protocols for sample collection and analysis will improve the reproducibility of miRNA studies, while a deeper understanding of miRNA biology may unlock their potential as therapeutic targets. In conclusion, this review consolidates current research on deregulated miRNAs in CC, highlighting their diagnostic and prognostic significance. The findings underscore the potential of miRNAs to revolutionize CC management through innovative diagnostic and therapeutic strategies. |
| format | Article |
| id | doaj-art-c0bd07e9518042c283a4ffa859d5c65b |
| institution | DOAJ |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-c0bd07e9518042c283a4ffa859d5c65b2025-08-20T03:22:03ZengSpringerDiscover Oncology2730-60112025-05-0116112210.1007/s12672-025-02744-4The role and diagnostic value of deregulated miRNAs in cervical cancerMasoumeh Parvizi0Maryam Vaezi1Farhad Jeddi2Masoumeh Bakhshandeh3Reza Eghdam-Zamiri4Noushin Mobaraki-Asl5Ebrahim Esmati6Abbas Karimi7Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical SciencesObstetric and Oncology Department, School of Medicine, Women’s Reproductive Health Research Center, Clinical Research Institute, Alzahra Hospital, Tabriz University of Medical SciencesDepartment of Genetics and Pathology, School of Medicine, Ardabil University of Medical SciencesObstetric and Oncology Department, School of Medicine, Women’s Reproductive Health Research Center, Clinical Research Institute, Alzahra Hospital, Tabriz University of Medical SciencesDepartment of Radiation Oncology, School of Medicine, Tabriz University of Medical SciencesDepartment of Obstetrics and Gynecology, School of Medicine, Alavi Hospital, Ardabil University of Medical SciencesDepartment of Radiation Oncology, Cancer Institute, IKHC, Tehran University of Medical SciencesDepartment of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical SciencesAbstract Cervical cancer (CC) remains a significant global health concern, particularly affecting women in low-income countries. Despite advancements in screening programs, CC continues to pose a substantial mortality risk, highlighting the need to explore diagnostic and treatment modalities. This review focuses on the role of deregulated microRNAs (miRNAs) in CC development, emphasizing their potential as biomarkers for early detection and prognosis in body fluids. miRNAs have emerged as critical regulators of key cellular processes, including proliferation, migration, invasion, and apoptosis, and their dysregulation is closely linked to CC progression. Upregulated miRNAs such as miR-146b-3p, miR-1908, and miR-21 promote CC progression by targeting tumor suppressor genes, while downregulated miRNAs like miR-23-3p and miR-4262 are associated with reduced tumor aggressiveness. miRNAs also hold significant promise as non-invasive prognostic biomarkers. Their expression levels correlate with clinical outcomes, including tumor stage, metastasis, and overall survival, making them valuable tools for risk stratification and personalized treatment strategies. Liquid biopsies, which detect circulating miRNAs in bodily fluids, offer a minimally invasive approach to monitor tumor dynamics and predict patient outcomes. Furthermore, exosomal miRNAs are emerging as promising diagnostic and prognostic tools for CC. Advanced diagnostic technologies and bioinformatics tools are anticipated to enhance the identification of evident miRNA biomarkers in the clinical settings. Standardized protocols for sample collection and analysis will improve the reproducibility of miRNA studies, while a deeper understanding of miRNA biology may unlock their potential as therapeutic targets. In conclusion, this review consolidates current research on deregulated miRNAs in CC, highlighting their diagnostic and prognostic significance. The findings underscore the potential of miRNAs to revolutionize CC management through innovative diagnostic and therapeutic strategies.https://doi.org/10.1007/s12672-025-02744-4Uterine Cervical NeoplasmsMicroRNAsLiquid BiopsyDiagnosisHuman Papillomavirus |
| spellingShingle | Masoumeh Parvizi Maryam Vaezi Farhad Jeddi Masoumeh Bakhshandeh Reza Eghdam-Zamiri Noushin Mobaraki-Asl Ebrahim Esmati Abbas Karimi The role and diagnostic value of deregulated miRNAs in cervical cancer Discover Oncology Uterine Cervical Neoplasms MicroRNAs Liquid Biopsy Diagnosis Human Papillomavirus |
| title | The role and diagnostic value of deregulated miRNAs in cervical cancer |
| title_full | The role and diagnostic value of deregulated miRNAs in cervical cancer |
| title_fullStr | The role and diagnostic value of deregulated miRNAs in cervical cancer |
| title_full_unstemmed | The role and diagnostic value of deregulated miRNAs in cervical cancer |
| title_short | The role and diagnostic value of deregulated miRNAs in cervical cancer |
| title_sort | role and diagnostic value of deregulated mirnas in cervical cancer |
| topic | Uterine Cervical Neoplasms MicroRNAs Liquid Biopsy Diagnosis Human Papillomavirus |
| url | https://doi.org/10.1007/s12672-025-02744-4 |
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