Deep-insights: Nanoengineered gel-based localized drug delivery for arthritis management
Arthritis is an inflammatory joint disorder that progressively impairs function and diminishes quality of life. Conventional therapies often prove ineffective, as oral administration lacks specificity, resulting in off-target side effects like hepatotoxicity and GIT-related issues. Intravenous admin...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087624001296 |
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| author | Anitha Sriram Harshada Ithape Pankaj Kumar Singh |
| author_facet | Anitha Sriram Harshada Ithape Pankaj Kumar Singh |
| author_sort | Anitha Sriram |
| collection | DOAJ |
| description | Arthritis is an inflammatory joint disorder that progressively impairs function and diminishes quality of life. Conventional therapies often prove ineffective, as oral administration lacks specificity, resulting in off-target side effects like hepatotoxicity and GIT-related issues. Intravenous administration causes systemic side effects. The characteristic joint-localized symptoms such as pain, stiffness, and inflammation make the localized drug delivery suitable for managing arthritis. Topical/transdermal/intra-articular routes have become viable options for drug delivery in treating arthritis. However, challenges with those localized drug delivery routes include skin barrier and cartilage impermeability. Additionally, conventional intra-articular drug delivery also leads to rapid clearance of drugs from the synovial joint tissue. To circumvent these limitations, researchers have developed nanocarriers that enhance drug permeability through skin and cartilage, influencing localized action. Gel-based nanoengineered therapy employs a gel matrix to incorporate the drug-encapsulated nanocarriers. This approach combines the benefits of gels and nanocarriers to enhance therapeutic effects and improve patient compliance. This review emphasizes deep insights into drug delivery using diverse gel-based novel nanocarriers, exploring their various applications embedded in hyaluronic acid (biopolymer)–based gels, carbopol-based gels, and others. Furthermore, this review discusses the influence of nanocarrier pharmacokinetics on the localization and therapeutic manipulation of macrophages mediated by nanocarriers. The ELVIS (extravasation through leaky vasculature and inflammatory cell-mediated sequestration) effect associated with arthritis is advantageous in drug delivery. Simply put, the ELVIS effect refers to the extravasation of nanocarriers through leaky vasculatures, which finally results in the accumulation of nanocarriers in the joint cavity. |
| format | Article |
| id | doaj-art-c0acb27e49d8453880a3686e0937850b |
| institution | Kabale University |
| issn | 1818-0876 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj-art-c0acb27e49d8453880a3686e0937850b2025-02-07T04:47:23ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762025-02-01201101012Deep-insights: Nanoengineered gel-based localized drug delivery for arthritis managementAnitha Sriram0Harshada Ithape1Pankaj Kumar Singh2Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Telangana 500037, IndiaDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Telangana 500037, IndiaCorresponding author.; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Telangana 500037, IndiaArthritis is an inflammatory joint disorder that progressively impairs function and diminishes quality of life. Conventional therapies often prove ineffective, as oral administration lacks specificity, resulting in off-target side effects like hepatotoxicity and GIT-related issues. Intravenous administration causes systemic side effects. The characteristic joint-localized symptoms such as pain, stiffness, and inflammation make the localized drug delivery suitable for managing arthritis. Topical/transdermal/intra-articular routes have become viable options for drug delivery in treating arthritis. However, challenges with those localized drug delivery routes include skin barrier and cartilage impermeability. Additionally, conventional intra-articular drug delivery also leads to rapid clearance of drugs from the synovial joint tissue. To circumvent these limitations, researchers have developed nanocarriers that enhance drug permeability through skin and cartilage, influencing localized action. Gel-based nanoengineered therapy employs a gel matrix to incorporate the drug-encapsulated nanocarriers. This approach combines the benefits of gels and nanocarriers to enhance therapeutic effects and improve patient compliance. This review emphasizes deep insights into drug delivery using diverse gel-based novel nanocarriers, exploring their various applications embedded in hyaluronic acid (biopolymer)–based gels, carbopol-based gels, and others. Furthermore, this review discusses the influence of nanocarrier pharmacokinetics on the localization and therapeutic manipulation of macrophages mediated by nanocarriers. The ELVIS (extravasation through leaky vasculature and inflammatory cell-mediated sequestration) effect associated with arthritis is advantageous in drug delivery. Simply put, the ELVIS effect refers to the extravasation of nanocarriers through leaky vasculatures, which finally results in the accumulation of nanocarriers in the joint cavity.http://www.sciencedirect.com/science/article/pii/S1818087624001296Gel-based nanocarriersArthritisCarbopolHydrogelsPharmacokinetics |
| spellingShingle | Anitha Sriram Harshada Ithape Pankaj Kumar Singh Deep-insights: Nanoengineered gel-based localized drug delivery for arthritis management Asian Journal of Pharmaceutical Sciences Gel-based nanocarriers Arthritis Carbopol Hydrogels Pharmacokinetics |
| title | Deep-insights: Nanoengineered gel-based localized drug delivery for arthritis management |
| title_full | Deep-insights: Nanoengineered gel-based localized drug delivery for arthritis management |
| title_fullStr | Deep-insights: Nanoengineered gel-based localized drug delivery for arthritis management |
| title_full_unstemmed | Deep-insights: Nanoengineered gel-based localized drug delivery for arthritis management |
| title_short | Deep-insights: Nanoengineered gel-based localized drug delivery for arthritis management |
| title_sort | deep insights nanoengineered gel based localized drug delivery for arthritis management |
| topic | Gel-based nanocarriers Arthritis Carbopol Hydrogels Pharmacokinetics |
| url | http://www.sciencedirect.com/science/article/pii/S1818087624001296 |
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