CircASH1L inhibits ferroptosis and enhances cisplatin resistance by sponging miR-515-5p to regulate cell cycle-related CDCA7/RRM2 in ovarian cancer cells

CircASH1L inhibits ferroptosis and enhances cisplatin resistance by sponging miR-515-5p to regulate cell cycle-related CDCA7/RRM2 in ovarian cancer cells

BackgroundPlatinum chemotherapy, particularly cisplatin, has been the standard treatment for ovarian cancer. However, the development of resistance to cisplatin is a significant challenge during treatment. Circular RNAs (circRNAs) are a class of non-coding RNAs with a circular structure and have bee...

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Bibliographic Details
Main Authors: Lu Feng, Xinru Zou, Longyu Tang, Yijun Yuan, Tianwen He, Bin Su, Ying Tang, Jiang Wang, Kang Liu, Jun Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
circASH1L
cisplatin resistance
ovarian cancer
ferroptosis
miR-515-5p
CDCA7
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1563869/full
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