Claustrum modulation drives altered prefrontal cortex dynamics and connectivity
Abstract This study delves into the claustrum’s role in modulating spontaneous and sensory-evoked network activity across cortical regions. Using mesoscale calcium imaging and Gi and Gq DREADDs in anesthetized mice, we show that decreasing claustral activity enhances prefrontal cortical activity, wh...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-07256-5 |
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| _version_ | 1849221028262182912 |
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| author | Ryan Zahacy Yonglie Ma Ian R. Winship Jesse Jackson Allen W. Chan |
| author_facet | Ryan Zahacy Yonglie Ma Ian R. Winship Jesse Jackson Allen W. Chan |
| author_sort | Ryan Zahacy |
| collection | DOAJ |
| description | Abstract This study delves into the claustrum’s role in modulating spontaneous and sensory-evoked network activity across cortical regions. Using mesoscale calcium imaging and Gi and Gq DREADDs in anesthetized mice, we show that decreasing claustral activity enhances prefrontal cortical activity, while activation reduces prefrontal cortical activity. This claustrum modulation also caused changes to the brain’s large-scale functional networks, emphasizing the claustrum’s ability to influence long-range functional connectivity in the cortex. Claustrum inhibition increased the local coupling between frontal cortex areas, but reduced the correlation between anterior medial regions and lateral/posterior regions, while also enhancing sensory-evoked responses in the visual cortex. These findings indicate the claustrum can participate in orchestrating neural communication across cortical regions through modulation of prefrontal cortical activity. These insights deepen our understanding of the claustrum’s impact on prefrontal connectivity, large-scale network dynamics, and sensory processing, positioning the claustrum as a key node modulating large-scale cortical dynamics. |
| format | Article |
| id | doaj-art-c0a7a5c6e74b4a108582e663a4ffe47a |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-c0a7a5c6e74b4a108582e663a4ffe47a2024-11-24T12:39:06ZengNature PortfolioCommunications Biology2399-36422024-11-017111210.1038/s42003-024-07256-5Claustrum modulation drives altered prefrontal cortex dynamics and connectivityRyan Zahacy0Yonglie Ma1Ian R. Winship2Jesse Jackson3Allen W. Chan4Neuroscience and Mental Health Institute, University of AlbertaDepartment of Psychiatry, University of AlbertaNeuroscience and Mental Health Institute, University of AlbertaNeuroscience and Mental Health Institute, University of AlbertaNeuroscience and Mental Health Institute, University of AlbertaAbstract This study delves into the claustrum’s role in modulating spontaneous and sensory-evoked network activity across cortical regions. Using mesoscale calcium imaging and Gi and Gq DREADDs in anesthetized mice, we show that decreasing claustral activity enhances prefrontal cortical activity, while activation reduces prefrontal cortical activity. This claustrum modulation also caused changes to the brain’s large-scale functional networks, emphasizing the claustrum’s ability to influence long-range functional connectivity in the cortex. Claustrum inhibition increased the local coupling between frontal cortex areas, but reduced the correlation between anterior medial regions and lateral/posterior regions, while also enhancing sensory-evoked responses in the visual cortex. These findings indicate the claustrum can participate in orchestrating neural communication across cortical regions through modulation of prefrontal cortical activity. These insights deepen our understanding of the claustrum’s impact on prefrontal connectivity, large-scale network dynamics, and sensory processing, positioning the claustrum as a key node modulating large-scale cortical dynamics.https://doi.org/10.1038/s42003-024-07256-5 |
| spellingShingle | Ryan Zahacy Yonglie Ma Ian R. Winship Jesse Jackson Allen W. Chan Claustrum modulation drives altered prefrontal cortex dynamics and connectivity Communications Biology |
| title | Claustrum modulation drives altered prefrontal cortex dynamics and connectivity |
| title_full | Claustrum modulation drives altered prefrontal cortex dynamics and connectivity |
| title_fullStr | Claustrum modulation drives altered prefrontal cortex dynamics and connectivity |
| title_full_unstemmed | Claustrum modulation drives altered prefrontal cortex dynamics and connectivity |
| title_short | Claustrum modulation drives altered prefrontal cortex dynamics and connectivity |
| title_sort | claustrum modulation drives altered prefrontal cortex dynamics and connectivity |
| url | https://doi.org/10.1038/s42003-024-07256-5 |
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