Enhancement of water radiolysis in the presence of nanodiamond sensitizers: Insights from interfacial hydroxyl radical formation under X-ray irradiation
Being low-Z materials, nanodiamonds (NDs) have garnered limited attention for their potential in radiosensitization. Under ionizing radiation, water undergoes radiolysis, generating species such as •O2−, •OH, H2O2, etc. To investigate the impact of nanodiamond concentration and particle size on the...
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| Language: | English |
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Elsevier
2025-07-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715625005016 |
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| author | Bowen Zhang Changfeng Yang Feifan Zhao Xiaoqian Lin Yan Liu |
| author_facet | Bowen Zhang Changfeng Yang Feifan Zhao Xiaoqian Lin Yan Liu |
| author_sort | Bowen Zhang |
| collection | DOAJ |
| description | Being low-Z materials, nanodiamonds (NDs) have garnered limited attention for their potential in radiosensitization. Under ionizing radiation, water undergoes radiolysis, generating species such as •O2−, •OH, H2O2, etc. To investigate the impact of nanodiamond concentration and particle size on the generation of reactive oxygen species (ROS) under X-ray irradiation, we utilized coumarin-3-carboxylic acid as a specific probe for hydroxyl radicals in this study. We defined an enhancement factor to reflect the sensitization effect. As the concentration increased, the enhancement factor initially rose and then declined, peaking at 10 μg/mL; similarly, with increasing particle size, an overall comparable trend was observed, where NDs between 240 and 260 nm generated the most ROS. Factors such as the recombination of hydroxyl radicals influenced the changes in the enhancement factor. The particle size, concentration, and surface modification of NDs could also affect the radiolytic reactions during X-ray irradiation, and we have explored potential mechanisms. |
| format | Article |
| id | doaj-art-c0a202f78c12458c8f7aa79a3bc421fc |
| institution | DOAJ |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-c0a202f78c12458c8f7aa79a3bc421fc2025-08-20T03:23:22ZengElsevierResults in Chemistry2211-71562025-07-011610251810.1016/j.rechem.2025.102518Enhancement of water radiolysis in the presence of nanodiamond sensitizers: Insights from interfacial hydroxyl radical formation under X-ray irradiationBowen Zhang0Changfeng Yang1Feifan Zhao2Xiaoqian Lin3Yan Liu4Translational Radiation Oncology and Medical Physics Research Unit, School of Medical Imaging, Binzhou Medical University, Yantai 264003, PR ChinaTranslational Radiation Oncology and Medical Physics Research Unit, School of Medical Imaging, Binzhou Medical University, Yantai 264003, PR ChinaTranslational Radiation Oncology and Medical Physics Research Unit, School of Medical Imaging, Binzhou Medical University, Yantai 264003, PR ChinaTranslational Radiation Oncology and Medical Physics Research Unit, School of Medical Imaging, Binzhou Medical University, Yantai 264003, PR ChinaTranslational Radiation Oncology and Medical Physics Research Unit, School of Medical Imaging, Binzhou Medical University, Yantai 264003, PR China; National Laboratory of Heavy Ion Research Facility in Lanzhou, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China; Corresponding author at: Translational Radiation Oncology and Medical Physics Research Unit, School of Medical Imaging, Binzhou Medical University, Yantai 264003, PR China.Being low-Z materials, nanodiamonds (NDs) have garnered limited attention for their potential in radiosensitization. Under ionizing radiation, water undergoes radiolysis, generating species such as •O2−, •OH, H2O2, etc. To investigate the impact of nanodiamond concentration and particle size on the generation of reactive oxygen species (ROS) under X-ray irradiation, we utilized coumarin-3-carboxylic acid as a specific probe for hydroxyl radicals in this study. We defined an enhancement factor to reflect the sensitization effect. As the concentration increased, the enhancement factor initially rose and then declined, peaking at 10 μg/mL; similarly, with increasing particle size, an overall comparable trend was observed, where NDs between 240 and 260 nm generated the most ROS. Factors such as the recombination of hydroxyl radicals influenced the changes in the enhancement factor. The particle size, concentration, and surface modification of NDs could also affect the radiolytic reactions during X-ray irradiation, and we have explored potential mechanisms.http://www.sciencedirect.com/science/article/pii/S2211715625005016RadiosensitizationNanodiamondsRadiolysisHydroxyl radicalCoumarin-3-carboxylic acid |
| spellingShingle | Bowen Zhang Changfeng Yang Feifan Zhao Xiaoqian Lin Yan Liu Enhancement of water radiolysis in the presence of nanodiamond sensitizers: Insights from interfacial hydroxyl radical formation under X-ray irradiation Results in Chemistry Radiosensitization Nanodiamonds Radiolysis Hydroxyl radical Coumarin-3-carboxylic acid |
| title | Enhancement of water radiolysis in the presence of nanodiamond sensitizers: Insights from interfacial hydroxyl radical formation under X-ray irradiation |
| title_full | Enhancement of water radiolysis in the presence of nanodiamond sensitizers: Insights from interfacial hydroxyl radical formation under X-ray irradiation |
| title_fullStr | Enhancement of water radiolysis in the presence of nanodiamond sensitizers: Insights from interfacial hydroxyl radical formation under X-ray irradiation |
| title_full_unstemmed | Enhancement of water radiolysis in the presence of nanodiamond sensitizers: Insights from interfacial hydroxyl radical formation under X-ray irradiation |
| title_short | Enhancement of water radiolysis in the presence of nanodiamond sensitizers: Insights from interfacial hydroxyl radical formation under X-ray irradiation |
| title_sort | enhancement of water radiolysis in the presence of nanodiamond sensitizers insights from interfacial hydroxyl radical formation under x ray irradiation |
| topic | Radiosensitization Nanodiamonds Radiolysis Hydroxyl radical Coumarin-3-carboxylic acid |
| url | http://www.sciencedirect.com/science/article/pii/S2211715625005016 |
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