Enhancement of water radiolysis in the presence of nanodiamond sensitizers: Insights from interfacial hydroxyl radical formation under X-ray irradiation
Being low-Z materials, nanodiamonds (NDs) have garnered limited attention for their potential in radiosensitization. Under ionizing radiation, water undergoes radiolysis, generating species such as •O2−, •OH, H2O2, etc. To investigate the impact of nanodiamond concentration and particle size on the...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-07-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715625005016 |
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| Summary: | Being low-Z materials, nanodiamonds (NDs) have garnered limited attention for their potential in radiosensitization. Under ionizing radiation, water undergoes radiolysis, generating species such as •O2−, •OH, H2O2, etc. To investigate the impact of nanodiamond concentration and particle size on the generation of reactive oxygen species (ROS) under X-ray irradiation, we utilized coumarin-3-carboxylic acid as a specific probe for hydroxyl radicals in this study. We defined an enhancement factor to reflect the sensitization effect. As the concentration increased, the enhancement factor initially rose and then declined, peaking at 10 μg/mL; similarly, with increasing particle size, an overall comparable trend was observed, where NDs between 240 and 260 nm generated the most ROS. Factors such as the recombination of hydroxyl radicals influenced the changes in the enhancement factor. The particle size, concentration, and surface modification of NDs could also affect the radiolytic reactions during X-ray irradiation, and we have explored potential mechanisms. |
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| ISSN: | 2211-7156 |