HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature
Primary effusion lymphoma (PEL) is a rare extranodal lymphoma that typically presents in a body cavity in the absence of a detectable tumor mass and that occurs predominantly in immunosuppressed individuals. The neoplastic lymphoid cells are frequently infected with human herpes virus 8 (HHV8), also...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/292301 |
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| author | Neeraj Saini Ephraim P. Hochberg Erica A. Linden Smita Jha Heinz K. Grohs Aliyah R. Sohani |
| author_facet | Neeraj Saini Ephraim P. Hochberg Erica A. Linden Smita Jha Heinz K. Grohs Aliyah R. Sohani |
| author_sort | Neeraj Saini |
| collection | DOAJ |
| description | Primary effusion lymphoma (PEL) is a rare extranodal lymphoma that typically presents in a body cavity in the absence of a detectable tumor mass and that occurs predominantly in immunosuppressed individuals. The neoplastic lymphoid cells are frequently infected with human herpes virus 8 (HHV8), also known as Kaposi sarcoma herpes virus (KSHV). We describe two HIV-negative patients who presented with primary effusion lymphoma of B-cell lineage involving the pleural cavity, but whose tumor cells lacked infection by HHV8. We review the English language literature of HHV8-negative PEL of B-cell lineage and compare these lymphomas to HHV8-associated PEL with regard to clinical and pathological characteristics, therapy, and outcome. |
| format | Article |
| id | doaj-art-c0a080d8b9c3475f94c6acb23a23311b |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-c0a080d8b9c3475f94c6acb23a23311b2025-02-03T01:08:51ZengWileyCase Reports in Oncological Medicine2090-67062090-67142013-01-01201310.1155/2013/292301292301HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the LiteratureNeeraj Saini0Ephraim P. Hochberg1Erica A. Linden2Smita Jha3Heinz K. Grohs4Aliyah R. Sohani5Department of Internal Medicine, North Shore Medical Center, Salem, MA 01970, USACenter for Lymphoma, MGH Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USADepartment of Internal Medicine, North Shore Medical Center, Salem, MA 01970, USADepartment of Internal Medicine, North Shore Medical Center, Salem, MA 01970, USADepartment of Pathology, North Shore Medical Center, Salem, MA 01970, USADepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USAPrimary effusion lymphoma (PEL) is a rare extranodal lymphoma that typically presents in a body cavity in the absence of a detectable tumor mass and that occurs predominantly in immunosuppressed individuals. The neoplastic lymphoid cells are frequently infected with human herpes virus 8 (HHV8), also known as Kaposi sarcoma herpes virus (KSHV). We describe two HIV-negative patients who presented with primary effusion lymphoma of B-cell lineage involving the pleural cavity, but whose tumor cells lacked infection by HHV8. We review the English language literature of HHV8-negative PEL of B-cell lineage and compare these lymphomas to HHV8-associated PEL with regard to clinical and pathological characteristics, therapy, and outcome.http://dx.doi.org/10.1155/2013/292301 |
| spellingShingle | Neeraj Saini Ephraim P. Hochberg Erica A. Linden Smita Jha Heinz K. Grohs Aliyah R. Sohani HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature Case Reports in Oncological Medicine |
| title | HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature |
| title_full | HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature |
| title_fullStr | HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature |
| title_full_unstemmed | HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature |
| title_short | HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature |
| title_sort | hhv8 negative primary effusion lymphoma of b cell lineage two cases and a comprehensive review of the literature |
| url | http://dx.doi.org/10.1155/2013/292301 |
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