Advances in hepatic arterial perfusion chemotherapy for hepatic metastases
Hepatic arterial infusion chemotherapy (HAIC) is one of the local treatment modalities employed for liver metastases. HAIC targets the delivery of chemotherapy drugs to the affected area by inserting a catheter into the tumor’s blood-supplying artery. This approach not only enhances drug concentrati...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1544061/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849471504360669184 |
|---|---|
| author | Haodi Ou Haodi Ou Xiaodong Li Xiaodong Li Shulin Chang Shulin Chang Guijie Li Feng Chen Song Jiang |
| author_facet | Haodi Ou Haodi Ou Xiaodong Li Xiaodong Li Shulin Chang Shulin Chang Guijie Li Feng Chen Song Jiang |
| author_sort | Haodi Ou |
| collection | DOAJ |
| description | Hepatic arterial infusion chemotherapy (HAIC) is one of the local treatment modalities employed for liver metastases. HAIC targets the delivery of chemotherapy drugs to the affected area by inserting a catheter into the tumor’s blood-supplying artery. This approach not only enhances drug concentration within the tumor site, but also significantly reduces systemic side effects. Currently, there are various chemotherapeutic regimens available for HAIC in liver metastases; however, determining the optimal therapeutic agent remains elusive. This article provides a comprehensive review of HAIC dosing regimens and multimodal therapy for liver metastases originating from colorectal, breast, and gastric cancers. Meanwhile, this paper briefly outlines ongoing research on HAIC treatment for liver metastases associated with esophageal cancer, gastroenteropancreatic neuroendocrine tumors, and uveal melanoma. |
| format | Article |
| id | doaj-art-c0a079f16ace4d069582a87f7f4b637c |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-c0a079f16ace4d069582a87f7f4b637c2025-08-20T03:24:48ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-06-011510.3389/fonc.2025.15440611544061Advances in hepatic arterial perfusion chemotherapy for hepatic metastasesHaodi Ou0Haodi Ou1Xiaodong Li2Xiaodong Li3Shulin Chang4Shulin Chang5Guijie Li6Feng Chen7Song Jiang8Department of Radiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Abdominal Medicine Imaging, Jinan, ChinaGraduate school, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Radiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Abdominal Medicine Imaging, Jinan, ChinaGraduate school, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Radiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Abdominal Medicine Imaging, Jinan, ChinaGraduate school, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Radiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Abdominal Medicine Imaging, Jinan, ChinaDepartment of Radiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Abdominal Medicine Imaging, Jinan, ChinaDepartment of Radiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Abdominal Medicine Imaging, Jinan, ChinaHepatic arterial infusion chemotherapy (HAIC) is one of the local treatment modalities employed for liver metastases. HAIC targets the delivery of chemotherapy drugs to the affected area by inserting a catheter into the tumor’s blood-supplying artery. This approach not only enhances drug concentration within the tumor site, but also significantly reduces systemic side effects. Currently, there are various chemotherapeutic regimens available for HAIC in liver metastases; however, determining the optimal therapeutic agent remains elusive. This article provides a comprehensive review of HAIC dosing regimens and multimodal therapy for liver metastases originating from colorectal, breast, and gastric cancers. Meanwhile, this paper briefly outlines ongoing research on HAIC treatment for liver metastases associated with esophageal cancer, gastroenteropancreatic neuroendocrine tumors, and uveal melanoma.https://www.frontiersin.org/articles/10.3389/fonc.2025.1544061/fullHAIChepatic metastasestreatmentchemotherapylocoregional therapy |
| spellingShingle | Haodi Ou Haodi Ou Xiaodong Li Xiaodong Li Shulin Chang Shulin Chang Guijie Li Feng Chen Song Jiang Advances in hepatic arterial perfusion chemotherapy for hepatic metastases Frontiers in Oncology HAIC hepatic metastases treatment chemotherapy locoregional therapy |
| title | Advances in hepatic arterial perfusion chemotherapy for hepatic metastases |
| title_full | Advances in hepatic arterial perfusion chemotherapy for hepatic metastases |
| title_fullStr | Advances in hepatic arterial perfusion chemotherapy for hepatic metastases |
| title_full_unstemmed | Advances in hepatic arterial perfusion chemotherapy for hepatic metastases |
| title_short | Advances in hepatic arterial perfusion chemotherapy for hepatic metastases |
| title_sort | advances in hepatic arterial perfusion chemotherapy for hepatic metastases |
| topic | HAIC hepatic metastases treatment chemotherapy locoregional therapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1544061/full |
| work_keys_str_mv | AT haodiou advancesinhepaticarterialperfusionchemotherapyforhepaticmetastases AT haodiou advancesinhepaticarterialperfusionchemotherapyforhepaticmetastases AT xiaodongli advancesinhepaticarterialperfusionchemotherapyforhepaticmetastases AT xiaodongli advancesinhepaticarterialperfusionchemotherapyforhepaticmetastases AT shulinchang advancesinhepaticarterialperfusionchemotherapyforhepaticmetastases AT shulinchang advancesinhepaticarterialperfusionchemotherapyforhepaticmetastases AT guijieli advancesinhepaticarterialperfusionchemotherapyforhepaticmetastases AT fengchen advancesinhepaticarterialperfusionchemotherapyforhepaticmetastases AT songjiang advancesinhepaticarterialperfusionchemotherapyforhepaticmetastases |