IPET-CT in inflammatory diseases of kidneys and bladder: diagnostic efficacy
Introduction. The incorporation of combined positron emission tomography-computed tomography (PET-CT) into clinical practice has significantly expanded the understanding of the pathogenesis of many diseases. Evidence-based data on the diagnostic efficacy in infectious and inflammatory diseases is in...
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| Format: | Article |
| Language: | Russian |
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Ministry of Health of Russian Federation, Rostov State Medical University, State Budget Educational Institute of Higher Professional Education
2021-12-01
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| Series: | Вестник урологии |
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| Online Access: | https://www.urovest.ru/jour/article/view/495 |
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| author | V. B. Berdichevsky B. A. Berdichevsky A. V. Romanova F. R. Rasulov A. A. Naletov S. V. Khilkevich E. I. Gutrova A. L. Boldyrev M. A. Korabelnikov |
| author_facet | V. B. Berdichevsky B. A. Berdichevsky A. V. Romanova F. R. Rasulov A. A. Naletov S. V. Khilkevich E. I. Gutrova A. L. Boldyrev M. A. Korabelnikov |
| author_sort | V. B. Berdichevsky |
| collection | DOAJ |
| description | Introduction. The incorporation of combined positron emission tomography-computed tomography (PET-CT) into clinical practice has significantly expanded the understanding of the pathogenesis of many diseases. Evidence-based data on the diagnostic efficacy in infectious and inflammatory diseases is increasing, making this imaging method very promising. Purpose of the study. To study the diagnostic efficacy of 18F-FDG PET-CT in various chronic inflammatory diseases of kidneys and bladder.Materials and methods. A retrospective study of the results of whole-body 18F-FDG PET-CT in 45 patients was carried out. Patients underwent an investigation at various times after surgical treatment of localized oncology of the anogenital zone at the T1N0M0 stage without the involvement of the genitourinary system. It was found that 24 patients had a history of chronic pyelonephritis and 21 patients had manifestations of radiation cystitis. Repeated PET/CT scans were performed after a course of therapy for inflammatory urological diseases to assess the treatment results of the underlying pathology.Results. The latent course of chronic renal failure was accompanied by a diffuse decrease in 18F-FDG metabolism in the renal parenchyma with its partial recovery after etiotropic therapy and urine sanitation. Hypermetabolism of 18F-FDG was detected in the bladder wall during manifestations of radiation cystitis, which was leveled during therapy and relief of urinary syndrome manifestations. Bacterial and radiation inflammation differed in molecular-cell responses to the pathogen, while the results of urinalysis, indicating the effectiveness of the treatment, coincided with the visual and digital indicators of the restoration of adequate energy metabolism in the studied tissues.Conclusions. Metabolism of 18F-FDG in the kidneys and bladder can objectively reflect the nature of inflammation and complement the data on the effectiveness of the treatment. |
| format | Article |
| id | doaj-art-c09ec8d86df14e41abcd02816c5eaa30 |
| institution | Kabale University |
| issn | 2308-6424 |
| language | Russian |
| publishDate | 2021-12-01 |
| publisher | Ministry of Health of Russian Federation, Rostov State Medical University, State Budget Educational Institute of Higher Professional Education |
| record_format | Article |
| series | Вестник урологии |
| spelling | doaj-art-c09ec8d86df14e41abcd02816c5eaa302025-08-20T03:57:12ZrusMinistry of Health of Russian Federation, Rostov State Medical University, State Budget Educational Institute of Higher Professional EducationВестник урологии2308-64242021-12-0194132010.21886/2308-6424-2021-9-4-13-20338IPET-CT in inflammatory diseases of kidneys and bladder: diagnostic efficacyV. B. Berdichevsky0B. A. Berdichevsky1A. V. Romanova2F. R. Rasulov3A. A. Naletov4S. V. Khilkevich5E. I. Gutrova6A. L. Boldyrev7M. A. Korabelnikov8Tyumen State Medical UniversityTyumen State Medical UniversityTyumen State Medical UniversityTyumen State Medical UniversityTyumen State Medical UniversityTyumen Regional Clinical Hospital No. 2Tyumen Regional Clinical Hospital No. 2Tyumen Regional Clinical Hospital No. 2625023, Tyumen, 12 Yu Semovskikh St.Introduction. The incorporation of combined positron emission tomography-computed tomography (PET-CT) into clinical practice has significantly expanded the understanding of the pathogenesis of many diseases. Evidence-based data on the diagnostic efficacy in infectious and inflammatory diseases is increasing, making this imaging method very promising. Purpose of the study. To study the diagnostic efficacy of 18F-FDG PET-CT in various chronic inflammatory diseases of kidneys and bladder.Materials and methods. A retrospective study of the results of whole-body 18F-FDG PET-CT in 45 patients was carried out. Patients underwent an investigation at various times after surgical treatment of localized oncology of the anogenital zone at the T1N0M0 stage without the involvement of the genitourinary system. It was found that 24 patients had a history of chronic pyelonephritis and 21 patients had manifestations of radiation cystitis. Repeated PET/CT scans were performed after a course of therapy for inflammatory urological diseases to assess the treatment results of the underlying pathology.Results. The latent course of chronic renal failure was accompanied by a diffuse decrease in 18F-FDG metabolism in the renal parenchyma with its partial recovery after etiotropic therapy and urine sanitation. Hypermetabolism of 18F-FDG was detected in the bladder wall during manifestations of radiation cystitis, which was leveled during therapy and relief of urinary syndrome manifestations. Bacterial and radiation inflammation differed in molecular-cell responses to the pathogen, while the results of urinalysis, indicating the effectiveness of the treatment, coincided with the visual and digital indicators of the restoration of adequate energy metabolism in the studied tissues.Conclusions. Metabolism of 18F-FDG in the kidneys and bladder can objectively reflect the nature of inflammation and complement the data on the effectiveness of the treatment.https://www.urovest.ru/jour/article/view/495pet- ct18f-fdg metabolisminflammationkidneysbladder |
| spellingShingle | V. B. Berdichevsky B. A. Berdichevsky A. V. Romanova F. R. Rasulov A. A. Naletov S. V. Khilkevich E. I. Gutrova A. L. Boldyrev M. A. Korabelnikov IPET-CT in inflammatory diseases of kidneys and bladder: diagnostic efficacy Вестник урологии pet- ct 18f-fdg metabolism inflammation kidneys bladder |
| title | IPET-CT in inflammatory diseases of kidneys and bladder: diagnostic efficacy |
| title_full | IPET-CT in inflammatory diseases of kidneys and bladder: diagnostic efficacy |
| title_fullStr | IPET-CT in inflammatory diseases of kidneys and bladder: diagnostic efficacy |
| title_full_unstemmed | IPET-CT in inflammatory diseases of kidneys and bladder: diagnostic efficacy |
| title_short | IPET-CT in inflammatory diseases of kidneys and bladder: diagnostic efficacy |
| title_sort | ipet ct in inflammatory diseases of kidneys and bladder diagnostic efficacy |
| topic | pet- ct 18f-fdg metabolism inflammation kidneys bladder |
| url | https://www.urovest.ru/jour/article/view/495 |
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