Ferroptosis-related genes as prognostic markers for survival and immunotherapy in triple-negative breast cancer: analysis of public databases and a single institution
Background: Ferroptosis plays a vital role in cancer development and treatment. The relationship between ferroptosis-related genes and breast cancer prognosis, as well as immunotherapy outcomes, remains unknown. Objectives: To evaluate the prognostic value of ferroptosis-related genes in breast canc...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-02-01
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| Series: | Therapeutic Advances in Medical Oncology |
| Online Access: | https://doi.org/10.1177/17588359251322291 |
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| _version_ | 1850284720381755392 |
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| author | Yizhao Xie Zhonghua Tao Biyun Wang Yannan Zhao Xinyu Chen Bin Li Jinyan Wang Guangliang Chen Xichun Hu |
| author_facet | Yizhao Xie Zhonghua Tao Biyun Wang Yannan Zhao Xinyu Chen Bin Li Jinyan Wang Guangliang Chen Xichun Hu |
| author_sort | Yizhao Xie |
| collection | DOAJ |
| description | Background: Ferroptosis plays a vital role in cancer development and treatment. The relationship between ferroptosis-related genes and breast cancer prognosis, as well as immunotherapy outcomes, remains unknown. Objectives: To evaluate the prognostic value of ferroptosis-related genes in breast cancer. Methods: We conducted differential expressions and prognostic analysis for ferroptosis-related genes on public databases and breast cancer patients in our center and analyzed their predictive value for immunotherapy of breast cancer patients. Results: We identified prognostic ferroptosis-related genes, constructed a nomogram, and validated key genes using patient data from our center. We also investigated ferroptosis-related genes significantly associated with immune infiltration and identified FTH1 as a promising biomarker for triple-negative breast cancer immunotherapy. Conclusion: Ferroptosis-related genes had potential prognostic value and predictive value for breast cancer immunotherapy. |
| format | Article |
| id | doaj-art-c0958d5eccda4dffb0131d0755e61d74 |
| institution | OA Journals |
| issn | 1758-8359 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Medical Oncology |
| spelling | doaj-art-c0958d5eccda4dffb0131d0755e61d742025-08-20T01:47:29ZengSAGE PublishingTherapeutic Advances in Medical Oncology1758-83592025-02-011710.1177/17588359251322291Ferroptosis-related genes as prognostic markers for survival and immunotherapy in triple-negative breast cancer: analysis of public databases and a single institutionYizhao XieZhonghua TaoBiyun WangYannan ZhaoXinyu ChenBin LiJinyan WangGuangliang ChenXichun HuBackground: Ferroptosis plays a vital role in cancer development and treatment. The relationship between ferroptosis-related genes and breast cancer prognosis, as well as immunotherapy outcomes, remains unknown. Objectives: To evaluate the prognostic value of ferroptosis-related genes in breast cancer. Methods: We conducted differential expressions and prognostic analysis for ferroptosis-related genes on public databases and breast cancer patients in our center and analyzed their predictive value for immunotherapy of breast cancer patients. Results: We identified prognostic ferroptosis-related genes, constructed a nomogram, and validated key genes using patient data from our center. We also investigated ferroptosis-related genes significantly associated with immune infiltration and identified FTH1 as a promising biomarker for triple-negative breast cancer immunotherapy. Conclusion: Ferroptosis-related genes had potential prognostic value and predictive value for breast cancer immunotherapy.https://doi.org/10.1177/17588359251322291 |
| spellingShingle | Yizhao Xie Zhonghua Tao Biyun Wang Yannan Zhao Xinyu Chen Bin Li Jinyan Wang Guangliang Chen Xichun Hu Ferroptosis-related genes as prognostic markers for survival and immunotherapy in triple-negative breast cancer: analysis of public databases and a single institution Therapeutic Advances in Medical Oncology |
| title | Ferroptosis-related genes as prognostic markers for survival and immunotherapy in triple-negative breast cancer: analysis of public databases and a single institution |
| title_full | Ferroptosis-related genes as prognostic markers for survival and immunotherapy in triple-negative breast cancer: analysis of public databases and a single institution |
| title_fullStr | Ferroptosis-related genes as prognostic markers for survival and immunotherapy in triple-negative breast cancer: analysis of public databases and a single institution |
| title_full_unstemmed | Ferroptosis-related genes as prognostic markers for survival and immunotherapy in triple-negative breast cancer: analysis of public databases and a single institution |
| title_short | Ferroptosis-related genes as prognostic markers for survival and immunotherapy in triple-negative breast cancer: analysis of public databases and a single institution |
| title_sort | ferroptosis related genes as prognostic markers for survival and immunotherapy in triple negative breast cancer analysis of public databases and a single institution |
| url | https://doi.org/10.1177/17588359251322291 |
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