Systemic inflammation accelerates neurodegeneration in a rat model of Parkinson’s disease overexpressing human alpha synuclein

Systemic inflammation accelerates neurodegeneration in a rat model of Parkinson’s disease overexpressing human alpha synuclein

Abstract Increasing efforts have been made to elucidate how genetic and environmental factors interact in Parkinson’s disease (PD). In the present study, we assessed the development of symptoms on a genetic PD rat model that overexpresses human α-synuclein (Snca +/+) at a presymptomatic age, exposed...

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Main Authors: Mariangela Massaro Cenere, Marta Tiberi, Emanuela Paldino, Sebastian Luca D’Addario, Mauro Federici, Cecilia Giacomet, Debora Cutuli, Alessandro Matteocci, Francesca Cossa, Beatrice Zarrilli, Nicolas Casadei, Ada Ledonne, Laura Petrosini, Nicola Berretta, Francesca Romana Fusco, Valerio Chiurchiù, Nicola B. Mercuri
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-024-00824-w
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