A genome-wide RNA interference screening reveals protectiveness of SNX5 knockdown in a Parkinson’s disease cell model

A genome-wide RNA interference screening reveals protectiveness of SNX5 knockdown in a Parkinson’s disease cell model

Abstract Background Alpha-synuclein (αSyn) is a major player in the pathophysiology of synucleinopathies, which include Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy. To date, there is no disease-modifying therapy available for these synucleinopathies. Furthermore, the...

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Main Authors: Matthias Höllerhage, Linghan Duan, Oscar Wing Ho Chua, Claudia Moebius, Svenja H. Bothe, Kristina Losse, Rebecca Kotzur, Kristina Lau, Franziska Hopfner, Franziska Richter, Christian Wahl-Schott, Marc Bickle, Günter U. Höglinger
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Translational Neurodegeneration
Subjects:
Genome-wide RNAi screening
Parkinson’s disease
Alpha-synuclein
Retromer
SNX5
Trans-Golgi network
Online Access:https://doi.org/10.1186/s40035-025-00486-5
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