Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders
Mitochondria are critical regulator of cell metabolism; thus, mitochondrial dysfunction is associated with many metabolic disorders. Defects in oxidative phosphorylation, ROS production, or mtDNA mutations are the main causes of mitochondrial dysfunction in many pathological conditions such as IR/di...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/604685 |
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| _version_ | 1849684651343347712 |
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| author | Daniela Sorriento Antonietta Valeria Pascale Rosa Finelli Anna Lisa Carillo Roberto Annunziata Bruno Trimarco Guido Iaccarino |
| author_facet | Daniela Sorriento Antonietta Valeria Pascale Rosa Finelli Anna Lisa Carillo Roberto Annunziata Bruno Trimarco Guido Iaccarino |
| author_sort | Daniela Sorriento |
| collection | DOAJ |
| description | Mitochondria are critical regulator of cell metabolism; thus, mitochondrial dysfunction is associated with many metabolic disorders. Defects in oxidative phosphorylation, ROS production, or mtDNA mutations are the main causes of mitochondrial dysfunction in many pathological conditions such as IR/diabetes, metabolic syndrome, cardiovascular diseases, and cancer. Thus, targeting mitochondria has been proposed as therapeutic approach for these conditions, leading to the development of small molecules to be tested in the clinical scenario. Here we discuss therapeutic interventions to treat mitochondrial dysfunction associated with two major metabolic disorders, metabolic syndrome, and cancer. Finally, novel mechanisms of regulation of mitochondrial function are discussed, which open new scenarios for mitochondria targeting. |
| format | Article |
| id | doaj-art-c0851034ee6c4a8599fa66a393e28db1 |
| institution | DOAJ |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-c0851034ee6c4a8599fa66a393e28db12025-08-20T03:23:24ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/604685604685Targeting Mitochondria as Therapeutic Strategy for Metabolic DisordersDaniela Sorriento0Antonietta Valeria Pascale1Rosa Finelli2Anna Lisa Carillo3Roberto Annunziata4Bruno Trimarco5Guido Iaccarino6Dipartimento di Scienze Biomediche Avanzate, Università Federico II, Via Pansini 5, 80131 Napoli, ItalyDipartimento di Medicina e Chirurgia, Università degli Studi di Salerno, Via Salvador Allende, 84081 Baronissi, ItalyDipartimento di Medicina e Chirurgia, Università degli Studi di Salerno, Via Salvador Allende, 84081 Baronissi, ItalyDipartimento di Scienze Biomediche Avanzate, Università Federico II, Via Pansini 5, 80131 Napoli, ItalyDipartimento di Scienze Biomediche Avanzate, Università Federico II, Via Pansini 5, 80131 Napoli, ItalyDipartimento di Scienze Biomediche Avanzate, Università Federico II, Via Pansini 5, 80131 Napoli, ItalyDipartimento di Medicina e Chirurgia, Università degli Studi di Salerno, Via Salvador Allende, 84081 Baronissi, ItalyMitochondria are critical regulator of cell metabolism; thus, mitochondrial dysfunction is associated with many metabolic disorders. Defects in oxidative phosphorylation, ROS production, or mtDNA mutations are the main causes of mitochondrial dysfunction in many pathological conditions such as IR/diabetes, metabolic syndrome, cardiovascular diseases, and cancer. Thus, targeting mitochondria has been proposed as therapeutic approach for these conditions, leading to the development of small molecules to be tested in the clinical scenario. Here we discuss therapeutic interventions to treat mitochondrial dysfunction associated with two major metabolic disorders, metabolic syndrome, and cancer. Finally, novel mechanisms of regulation of mitochondrial function are discussed, which open new scenarios for mitochondria targeting.http://dx.doi.org/10.1155/2014/604685 |
| spellingShingle | Daniela Sorriento Antonietta Valeria Pascale Rosa Finelli Anna Lisa Carillo Roberto Annunziata Bruno Trimarco Guido Iaccarino Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders The Scientific World Journal |
| title | Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders |
| title_full | Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders |
| title_fullStr | Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders |
| title_full_unstemmed | Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders |
| title_short | Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders |
| title_sort | targeting mitochondria as therapeutic strategy for metabolic disorders |
| url | http://dx.doi.org/10.1155/2014/604685 |
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