Immunogenicity and safety of self-amplifying mRNA COVID-19 vaccine (ARCT-2303), with or without co-administration of seasonal inactivated influenza vaccine in adults: a phase 3, randomised, controlled, observer-blind, multicentre studyResearch in context

Immunogenicity and safety of self-amplifying mRNA COVID-19 vaccine (ARCT-2303), with or without co-administration of seasonal inactivated influenza vaccine in adults: a phase 3, randomised, controlled, observer-blind, multicentre studyResearch in context

Summary: Background: A recently licenced self-amplifying mRNA (sa-mRNA) COVID-19 vaccine induces a robust, broad, and long-lasting immune response, extending the arsenal of efficacious COVID-19 countermeasures. We ran a clinical study to assess the benefits of vaccine strain update and the feasibil...

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Main Authors: Michelle L. Giles, Charissa Tabora, Carmen Baccarini, Leonela Barrientos, Javier Cespedes Vargas, May Emmeline Montellano, Paul Nguyen, Sachin Deshmukh, Munro Neville, Matthew Hohenboken, Josephine van Boxmeer, Hongfan Jin, Roberto Bugarini, Xuexuan Liu, Judd L. Walson, Carole Verhoeven, Igor Smolenov
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:EClinicalMedicine
Subjects:
Self-amplifying mRNA
COVID-19 vaccine
Co-administration
Immunogenicity
Safety
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537025003608
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