Stem Cells for Cardiac Repair: Status, Mechanisms, and New Strategies
Faced with the end stage of heart disease, the current treatments only slow worsening of heart failure. Stem cells have the potential of self-renewal and differentiation. It is expected to replace and repair damaged myocardium. But many clinical trials have shown that the stem cell therapy of heart...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.4061/2011/310928 |
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| author | Ren Mingliang Zhang Bo Wang Zhengguo |
| author_facet | Ren Mingliang Zhang Bo Wang Zhengguo |
| author_sort | Ren Mingliang |
| collection | DOAJ |
| description | Faced with the end stage of heart disease, the current treatments only slow worsening of heart failure. Stem cells have the potential of self-renewal and differentiation. It is expected to replace and repair damaged myocardium. But many clinical trials have shown that the stem cell therapy of heart failure is modest or not effective. The possible causes for the limited effects of stem cell in curing heart failure are the stem cells which have been transplanted into the ischemic heart muscle may suffer low survival rate, affected by inflammatory molecules, proapoptotic factor, and lack of nutrients and oxygen, and then the stem cells which home and have been completely transplanted to the site of myocardial infarction become very small. Therefore, through preconditioning of stem cells and appropriate choice of genes for mesenchymal stem cell modification to improve the survival rate of stem cells, ability in homing and promoting angiogenesis may become the newly effective strategies for the application of stem cells therapy in heart failure. |
| format | Article |
| id | doaj-art-c082be342f7d45abb8ab3b77fcf0cfc9 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-c082be342f7d45abb8ab3b77fcf0cfc92025-02-03T01:21:40ZengWileyStem Cells International1687-966X1687-96782011-01-01201110.4061/2011/310928310928Stem Cells for Cardiac Repair: Status, Mechanisms, and New StrategiesRen Mingliang0Zhang Bo1Wang Zhengguo2Department 4, State Key Laboratory of Trauma, Burn and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing 400042, ChinaDepartment 4, State Key Laboratory of Trauma, Burn and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing 400042, ChinaDepartment 4, State Key Laboratory of Trauma, Burn and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing 400042, ChinaFaced with the end stage of heart disease, the current treatments only slow worsening of heart failure. Stem cells have the potential of self-renewal and differentiation. It is expected to replace and repair damaged myocardium. But many clinical trials have shown that the stem cell therapy of heart failure is modest or not effective. The possible causes for the limited effects of stem cell in curing heart failure are the stem cells which have been transplanted into the ischemic heart muscle may suffer low survival rate, affected by inflammatory molecules, proapoptotic factor, and lack of nutrients and oxygen, and then the stem cells which home and have been completely transplanted to the site of myocardial infarction become very small. Therefore, through preconditioning of stem cells and appropriate choice of genes for mesenchymal stem cell modification to improve the survival rate of stem cells, ability in homing and promoting angiogenesis may become the newly effective strategies for the application of stem cells therapy in heart failure.http://dx.doi.org/10.4061/2011/310928 |
| spellingShingle | Ren Mingliang Zhang Bo Wang Zhengguo Stem Cells for Cardiac Repair: Status, Mechanisms, and New Strategies Stem Cells International |
| title | Stem Cells for Cardiac Repair: Status, Mechanisms, and New Strategies |
| title_full | Stem Cells for Cardiac Repair: Status, Mechanisms, and New Strategies |
| title_fullStr | Stem Cells for Cardiac Repair: Status, Mechanisms, and New Strategies |
| title_full_unstemmed | Stem Cells for Cardiac Repair: Status, Mechanisms, and New Strategies |
| title_short | Stem Cells for Cardiac Repair: Status, Mechanisms, and New Strategies |
| title_sort | stem cells for cardiac repair status mechanisms and new strategies |
| url | http://dx.doi.org/10.4061/2011/310928 |
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