The Acute-Phase Proteins Serum Amyloid A and C Reactive Protein in Transudates and Exudates
The distinction between exudates and transudates is very important in the patient management. Here we evaluate whether the acute-phase protein serum amyloid A (SAA), in comparison with C reactive protein (CRP) and total protein (TP), can be useful in this discrimination. CRP, SAA, and TP were dete...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/47297 |
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| author | Alessandra M. Okino Cristiani Bürger Jefferson R. Cardoso Edson L. Lavado Paulo A. Lotufo Ana Campa |
| author_facet | Alessandra M. Okino Cristiani Bürger Jefferson R. Cardoso Edson L. Lavado Paulo A. Lotufo Ana Campa |
| author_sort | Alessandra M. Okino |
| collection | DOAJ |
| description | The distinction between exudates and transudates is very important
in the patient management. Here we evaluate whether the
acute-phase protein serum amyloid A (SAA), in comparison with C
reactive protein (CRP) and total protein (TP), can be useful in
this discrimination. CRP, SAA, and TP were
determined in 36 exudate samples (27 pleural and 9 ascitic) and in
12 transudates (9 pleural and 3 ascitic). CRP, SAA, and TP
were measured. SAA present in the exudate
corresponded to
10%
of the amount found in serum, that is, the
exudate/serum ratio (E/S) was
0.10±0.13. For comparison, the
exudate/serum ratio for CRP and TP was
0.39±0.37
and 0.68±0.15, respectively. There was a strong positive correlation
between serum and exudate SAA concentration (r=0.764;p<0.0001). The concentration of SAA in transudates was low
and did not overlap with that found in exudates (0.02-0.21 versus
0.8–360.5 g/mL). SAA in pleural and ascitic exudates results
mainly from leakage of the serum protein via the inflamed
membrane. A comparison of the E/S ratio of SAA and CRP points SAA
as a very good marker in discriminating between exudates and
transudates |
| format | Article |
| id | doaj-art-c07f876862884b97a17341e6f27f97c5 |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c07f876862884b97a17341e6f27f97c52025-08-20T03:23:23ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/4729747297The Acute-Phase Proteins Serum Amyloid A and C Reactive Protein in Transudates and ExudatesAlessandra M. Okino0Cristiani Bürger1Jefferson R. Cardoso2Edson L. Lavado3Paulo A. Lotufo4Ana Campa5Departamento de Patologia, Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Estadual de Londrina, Paraná CEP 86051-990, BrazilDepartamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo CEP 05508-900, BrazilDepartamento de Fisioterapia, Centro de Ciências da Saúde, Universidade Estadual de Londrina, Paraná CEP 86051-990, BrazilDepartamento de Fisioterapia, Centro de Ciências da Saúde, Universidade Estadual de Londrina, Paraná CEP 86051-990, BrazilHospital Universitário, Universidade de São Paulo, São Paulo CEP 05508-900, BrazilDepartamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo CEP 05508-900, BrazilThe distinction between exudates and transudates is very important in the patient management. Here we evaluate whether the acute-phase protein serum amyloid A (SAA), in comparison with C reactive protein (CRP) and total protein (TP), can be useful in this discrimination. CRP, SAA, and TP were determined in 36 exudate samples (27 pleural and 9 ascitic) and in 12 transudates (9 pleural and 3 ascitic). CRP, SAA, and TP were measured. SAA present in the exudate corresponded to 10% of the amount found in serum, that is, the exudate/serum ratio (E/S) was 0.10±0.13. For comparison, the exudate/serum ratio for CRP and TP was 0.39±0.37 and 0.68±0.15, respectively. There was a strong positive correlation between serum and exudate SAA concentration (r=0.764;p<0.0001). The concentration of SAA in transudates was low and did not overlap with that found in exudates (0.02-0.21 versus 0.8–360.5 g/mL). SAA in pleural and ascitic exudates results mainly from leakage of the serum protein via the inflamed membrane. A comparison of the E/S ratio of SAA and CRP points SAA as a very good marker in discriminating between exudates and transudateshttp://dx.doi.org/10.1155/MI/2006/47297 |
| spellingShingle | Alessandra M. Okino Cristiani Bürger Jefferson R. Cardoso Edson L. Lavado Paulo A. Lotufo Ana Campa The Acute-Phase Proteins Serum Amyloid A and C Reactive Protein in Transudates and Exudates Mediators of Inflammation |
| title | The Acute-Phase Proteins Serum Amyloid A and C Reactive Protein in Transudates and Exudates |
| title_full | The Acute-Phase Proteins Serum Amyloid A and C Reactive Protein in Transudates and Exudates |
| title_fullStr | The Acute-Phase Proteins Serum Amyloid A and C Reactive Protein in Transudates and Exudates |
| title_full_unstemmed | The Acute-Phase Proteins Serum Amyloid A and C Reactive Protein in Transudates and Exudates |
| title_short | The Acute-Phase Proteins Serum Amyloid A and C Reactive Protein in Transudates and Exudates |
| title_sort | acute phase proteins serum amyloid a and c reactive protein in transudates and exudates |
| url | http://dx.doi.org/10.1155/MI/2006/47297 |
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