Twitch force in human Amyotrophic Lateral Sclerosis
IntroductionThis study investigated differences in muscle twitch force between slow and fast progressors of amyotrophic lateral sclerosis (ALS) to better understand disease heterogeneity and identify potential biomarkers of disease progression.MethodsForty-four ALS patients were classified as slow o...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1590950/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850187380031488000 |
|---|---|
| author | Laura Libonati Chiara Cambieri Marco Ceccanti Federica Moret Matteo Di Giulio Eleonora Palma Maurizio Inghilleri Maurizio Inghilleri |
| author_facet | Laura Libonati Chiara Cambieri Marco Ceccanti Federica Moret Matteo Di Giulio Eleonora Palma Maurizio Inghilleri Maurizio Inghilleri |
| author_sort | Laura Libonati |
| collection | DOAJ |
| description | IntroductionThis study investigated differences in muscle twitch force between slow and fast progressors of amyotrophic lateral sclerosis (ALS) to better understand disease heterogeneity and identify potential biomarkers of disease progression.MethodsForty-four ALS patients were classified as slow or fast progressors based on disease progression rates. Electrophysiological assessments, including compound muscle action potential (CMAP) and muscle force measurements, were conducted. Creatine kinase (CK) levels were also evaluated.ResultsSlow progressors demonstrated significantly higher muscle peak force and area under the curve (AUC) compared to fast progressors, reflecting greater muscle strength and endurance. CK levels were also elevated in slow progressors.DiscussionDespite similar CMAp values, slow progressors retained greater muscle strength, possibly due to a reduced degeneration of fast-twitch fibers and compensatory axonal sprouting. These adaptations may preserve muscle function and elevate CK levels, suggesting better muscle integrity in slow progressors.ConclusionMuscle function profiles and CK levels are promising indicators of ALS progression. These findings could enhance early detection of disease progression and lead to targeted interventions to preserve muscle function. Further research is needed to validate these results and explore the underlying functional mechanisms of disease heterogeneity. |
| format | Article |
| id | doaj-art-c07d07f10c2f4164a8d8e292c0e3a344 |
| institution | OA Journals |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-c07d07f10c2f4164a8d8e292c0e3a3442025-08-20T02:16:06ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-05-011610.3389/fneur.2025.15909501590950Twitch force in human Amyotrophic Lateral SclerosisLaura Libonati0Chiara Cambieri1Marco Ceccanti2Federica Moret3Matteo Di Giulio4Eleonora Palma5Maurizio Inghilleri6Maurizio Inghilleri7Department of Human Neurosciences, Rare Neuromuscular Diseases Center, Sapienza University of Rome, Viale Dell’Università, Rome, ItalyDepartment of Human Neurosciences, Rare Neuromuscular Diseases Center, Sapienza University of Rome, Viale Dell’Università, Rome, ItalyDepartment of Human Neurosciences, Rare Neuromuscular Diseases Center, Sapienza University of Rome, Viale Dell’Università, Rome, ItalyDepartment of Human Neurosciences, Rare Neuromuscular Diseases Center, Sapienza University of Rome, Viale Dell’Università, Rome, ItalyDepartment of Human Neurosciences, Rare Neuromuscular Diseases Center, Sapienza University of Rome, Viale Dell’Università, Rome, ItalyDepartment of Physiology and Pharmacology, Istituto Pasteur-Fondazione Cenci Bolognetti, University of Rome Sapienza, Rome, ItalyDepartment of Human Neurosciences, Rare Neuromuscular Diseases Center, Sapienza University of Rome, Viale Dell’Università, Rome, ItalyIRCCS Neuromed, Pozzilli, ItalyIntroductionThis study investigated differences in muscle twitch force between slow and fast progressors of amyotrophic lateral sclerosis (ALS) to better understand disease heterogeneity and identify potential biomarkers of disease progression.MethodsForty-four ALS patients were classified as slow or fast progressors based on disease progression rates. Electrophysiological assessments, including compound muscle action potential (CMAP) and muscle force measurements, were conducted. Creatine kinase (CK) levels were also evaluated.ResultsSlow progressors demonstrated significantly higher muscle peak force and area under the curve (AUC) compared to fast progressors, reflecting greater muscle strength and endurance. CK levels were also elevated in slow progressors.DiscussionDespite similar CMAp values, slow progressors retained greater muscle strength, possibly due to a reduced degeneration of fast-twitch fibers and compensatory axonal sprouting. These adaptations may preserve muscle function and elevate CK levels, suggesting better muscle integrity in slow progressors.ConclusionMuscle function profiles and CK levels are promising indicators of ALS progression. These findings could enhance early detection of disease progression and lead to targeted interventions to preserve muscle function. Further research is needed to validate these results and explore the underlying functional mechanisms of disease heterogeneity.https://www.frontiersin.org/articles/10.3389/fneur.2025.1590950/fullamyotrophic lateral sclerosismuscle functionelectromechanical couplingdisease phenotypedisease progression |
| spellingShingle | Laura Libonati Chiara Cambieri Marco Ceccanti Federica Moret Matteo Di Giulio Eleonora Palma Maurizio Inghilleri Maurizio Inghilleri Twitch force in human Amyotrophic Lateral Sclerosis Frontiers in Neurology amyotrophic lateral sclerosis muscle function electromechanical coupling disease phenotype disease progression |
| title | Twitch force in human Amyotrophic Lateral Sclerosis |
| title_full | Twitch force in human Amyotrophic Lateral Sclerosis |
| title_fullStr | Twitch force in human Amyotrophic Lateral Sclerosis |
| title_full_unstemmed | Twitch force in human Amyotrophic Lateral Sclerosis |
| title_short | Twitch force in human Amyotrophic Lateral Sclerosis |
| title_sort | twitch force in human amyotrophic lateral sclerosis |
| topic | amyotrophic lateral sclerosis muscle function electromechanical coupling disease phenotype disease progression |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1590950/full |
| work_keys_str_mv | AT lauralibonati twitchforceinhumanamyotrophiclateralsclerosis AT chiaracambieri twitchforceinhumanamyotrophiclateralsclerosis AT marcoceccanti twitchforceinhumanamyotrophiclateralsclerosis AT federicamoret twitchforceinhumanamyotrophiclateralsclerosis AT matteodigiulio twitchforceinhumanamyotrophiclateralsclerosis AT eleonorapalma twitchforceinhumanamyotrophiclateralsclerosis AT maurizioinghilleri twitchforceinhumanamyotrophiclateralsclerosis AT maurizioinghilleri twitchforceinhumanamyotrophiclateralsclerosis |