Advances in understanding the role of pentraxin-3 in lung infections
Pentraxin-3 (PTX3) is a soluble pattern recognition molecule (PRM) characterized by a C-terminal pentraxin structural domain and a unique N-terminal structural domain. As a key component of the innate immune system, PTX3 can be rapidly released into the extracellular space during microbial invasion...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-04-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1575968/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850150036034289664 |
|---|---|
| author | Li Ma Dongmei Li Yiyang Wen Dongmei Shi Dongmei Shi |
| author_facet | Li Ma Dongmei Li Yiyang Wen Dongmei Shi Dongmei Shi |
| author_sort | Li Ma |
| collection | DOAJ |
| description | Pentraxin-3 (PTX3) is a soluble pattern recognition molecule (PRM) characterized by a C-terminal pentraxin structural domain and a unique N-terminal structural domain. As a key component of the innate immune system, PTX3 can be rapidly released into the extracellular space during microbial invasion and inflammatory responses. It plays a crucial role in regulating complement activation, enhancing the ability of myeloid cells to recognize pathogens, and exerting various immune effects. PTX3 is integral to the regulation of innate immunity, inflammation, and tumor dynamics through its dual function as both a pro-inflammatory and anti-inflammatory mediator depending on the context. This role is closely linked to its diverse molecular and cellular targets. Additionally, PTX3 has been implicated in the pathogenesis of various lung diseases through its involvement in numerous physiological and pathological processes. In this paper, we summarize the complex immunological functions of PTX3 and review the multifaceted roles it plays in the development of infectious lung diseases. Our objective is to highlight the potential for clinical targeting of PTX3 as a biomarker in infectious diseases and to propose it as a viable alternative in future therapeutic strategies. |
| format | Article |
| id | doaj-art-c07b9f0d85034737a4354cf689fa3b0c |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-c07b9f0d85034737a4354cf689fa3b0c2025-08-20T02:26:41ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-04-011610.3389/fimmu.2025.15759681575968Advances in understanding the role of pentraxin-3 in lung infectionsLi Ma0Dongmei Li1Yiyang Wen2Dongmei Shi3Dongmei Shi4The Laboratory of Medical Mycology, Jining No.1 People’s Hospital, Jining, Shandong, ChinaDepartment of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC, United StatesDepartment of pathology, Jining No.1 People’s Hospital, Jining, Shandong, ChinaThe Laboratory of Medical Mycology, Jining No.1 People’s Hospital, Jining, Shandong, ChinaDepartment of Dermatology, Jining No.1 People’s Hospital, Jining, Shandong, ChinaPentraxin-3 (PTX3) is a soluble pattern recognition molecule (PRM) characterized by a C-terminal pentraxin structural domain and a unique N-terminal structural domain. As a key component of the innate immune system, PTX3 can be rapidly released into the extracellular space during microbial invasion and inflammatory responses. It plays a crucial role in regulating complement activation, enhancing the ability of myeloid cells to recognize pathogens, and exerting various immune effects. PTX3 is integral to the regulation of innate immunity, inflammation, and tumor dynamics through its dual function as both a pro-inflammatory and anti-inflammatory mediator depending on the context. This role is closely linked to its diverse molecular and cellular targets. Additionally, PTX3 has been implicated in the pathogenesis of various lung diseases through its involvement in numerous physiological and pathological processes. In this paper, we summarize the complex immunological functions of PTX3 and review the multifaceted roles it plays in the development of infectious lung diseases. Our objective is to highlight the potential for clinical targeting of PTX3 as a biomarker in infectious diseases and to propose it as a viable alternative in future therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1575968/fullpentraxin 3 (PTX3)lung infectionsinflammationcomplementbiomarkers |
| spellingShingle | Li Ma Dongmei Li Yiyang Wen Dongmei Shi Dongmei Shi Advances in understanding the role of pentraxin-3 in lung infections Frontiers in Immunology pentraxin 3 (PTX3) lung infections inflammation complement biomarkers |
| title | Advances in understanding the role of pentraxin-3 in lung infections |
| title_full | Advances in understanding the role of pentraxin-3 in lung infections |
| title_fullStr | Advances in understanding the role of pentraxin-3 in lung infections |
| title_full_unstemmed | Advances in understanding the role of pentraxin-3 in lung infections |
| title_short | Advances in understanding the role of pentraxin-3 in lung infections |
| title_sort | advances in understanding the role of pentraxin 3 in lung infections |
| topic | pentraxin 3 (PTX3) lung infections inflammation complement biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1575968/full |
| work_keys_str_mv | AT lima advancesinunderstandingtheroleofpentraxin3inlunginfections AT dongmeili advancesinunderstandingtheroleofpentraxin3inlunginfections AT yiyangwen advancesinunderstandingtheroleofpentraxin3inlunginfections AT dongmeishi advancesinunderstandingtheroleofpentraxin3inlunginfections AT dongmeishi advancesinunderstandingtheroleofpentraxin3inlunginfections |