IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells
Background: In inflammatory bowel disease (IBD), cytokine levels (such as interleukin-1 (IL-1)) are elevated. We have shown previously that IL-1 activates phospholipid signaling pathways in intestinal epithelial cells (IEC), leading to increased ceramide levels.
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2002-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629350210313 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564429257965568 |
|---|---|
| author | Fadia R. Homaidan Marwan E. El-Sabban Iman Chakroun Mirvat El-Sibai Ghassan S. Dbaibo |
| author_facet | Fadia R. Homaidan Marwan E. El-Sabban Iman Chakroun Mirvat El-Sibai Ghassan S. Dbaibo |
| author_sort | Fadia R. Homaidan |
| collection | DOAJ |
| description | Background: In inflammatory bowel disease (IBD), cytokine levels (such as interleukin-1 (IL-1)) are elevated. We have shown previously that IL-1 activates phospholipid signaling pathways in intestinal epithelial cells (IEC), leading to increased ceramide levels. |
| format | Article |
| id | doaj-art-c07ad54111f9496b99be7e7848d63229 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2002-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c07ad54111f9496b99be7e7848d632292025-02-03T01:11:04ZengWileyMediators of Inflammation0962-93511466-18612002-01-01111394510.1080/09629350210313IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cellsFadia R. Homaidan0Marwan E. El-Sabban1Iman Chakroun2Mirvat El-Sibai3Ghassan S. Dbaibo4Department of Physiology, Faculty of Medicine, American University of Beirut, Beirut, LebanonDepartment of Human Morphology, Faculty of Medicine, American University of Beirut, Beirut, LebanonDepartment of Physiology, Faculty of Medicine, American University of Beirut, Beirut, LebanonDepartment of Physiology, Faculty of Medicine, American University of Beirut, Beirut, LebanonDepartment of Pediatrics, Faculty of Medicine, American University of Beirut, Beirut, LebanonBackground: In inflammatory bowel disease (IBD), cytokine levels (such as interleukin-1 (IL-1)) are elevated. We have shown previously that IL-1 activates phospholipid signaling pathways in intestinal epithelial cells (IEC), leading to increased ceramide levels.http://dx.doi.org/10.1080/09629350210313 |
| spellingShingle | Fadia R. Homaidan Marwan E. El-Sabban Iman Chakroun Mirvat El-Sibai Ghassan S. Dbaibo IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells Mediators of Inflammation |
| title | IL-1 stimulates ceramide accumulation without
inducing apoptosis in intestinal epithelial cells |
| title_full | IL-1 stimulates ceramide accumulation without
inducing apoptosis in intestinal epithelial cells |
| title_fullStr | IL-1 stimulates ceramide accumulation without
inducing apoptosis in intestinal epithelial cells |
| title_full_unstemmed | IL-1 stimulates ceramide accumulation without
inducing apoptosis in intestinal epithelial cells |
| title_short | IL-1 stimulates ceramide accumulation without
inducing apoptosis in intestinal epithelial cells |
| title_sort | il 1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells |
| url | http://dx.doi.org/10.1080/09629350210313 |
| work_keys_str_mv | AT fadiarhomaidan il1stimulatesceramideaccumulationwithoutinducingapoptosisinintestinalepithelialcells AT marwaneelsabban il1stimulatesceramideaccumulationwithoutinducingapoptosisinintestinalepithelialcells AT imanchakroun il1stimulatesceramideaccumulationwithoutinducingapoptosisinintestinalepithelialcells AT mirvatelsibai il1stimulatesceramideaccumulationwithoutinducingapoptosisinintestinalepithelialcells AT ghassansdbaibo il1stimulatesceramideaccumulationwithoutinducingapoptosisinintestinalepithelialcells |