Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant Agents
Flavonoids are phenolic compounds found commonly in plants that protect them against the negative effects of environmental insults. These secondary metabolites have been widely studied in preclinical research because of their biological effects, particularly as antioxidant agents. Diverse flavonoids...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2018/2963565 |
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| author | León Jesús German-Ponciano Gilberto Uriel Rosas-Sánchez Eduardo Rivadeneyra-Domínguez Juan Francisco Rodríguez-Landa |
| author_facet | León Jesús German-Ponciano Gilberto Uriel Rosas-Sánchez Eduardo Rivadeneyra-Domínguez Juan Francisco Rodríguez-Landa |
| author_sort | León Jesús German-Ponciano |
| collection | DOAJ |
| description | Flavonoids are phenolic compounds found commonly in plants that protect them against the negative effects of environmental insults. These secondary metabolites have been widely studied in preclinical research because of their biological effects, particularly as antioxidant agents. Diverse flavonoids have been studied to explore their potential therapeutic effects in the treatment of disorders of the central nervous system, including anxiety and depression. The present review discusses advances in the study of some flavonoids as potential antidepressant agents. We describe their behavioral, physiological, and neurochemical effects and the apparent mechanism of action of their preclinical antidepressant-like effects. Natural flavonoids produce antidepressant-like effects in validated behavioral models of depression. The mechanism of action of these effects includes the activation of serotonergic, dopaminergic, noradrenergic, and γ-aminobutyric acid-ergic neurotransmitter systems and an increase in the production of neural factors, including brain-derived neurotrophic factor and nerve growth factor. Additionally, alterations in the function of tropomyosin receptor kinase B and activity of the enzyme monoamine oxidase A have been reported. In conclusion, preclinical research supports the potential antidepressant effects of some natural flavonoids, which opens new possibilities of evaluating these substances to develop complementary therapeutic alternatives that could ameliorate symptoms of depressive disorders in humans. |
| format | Article |
| id | doaj-art-c0767e390cfa4408a24bfd6ce90d6695 |
| institution | OA Journals |
| issn | 2090-908X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-c0767e390cfa4408a24bfd6ce90d66952025-08-20T02:19:23ZengWileyScientifica2090-908X2018-01-01201810.1155/2018/29635652963565Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant AgentsLeón Jesús German-Ponciano0Gilberto Uriel Rosas-Sánchez1Eduardo Rivadeneyra-Domínguez2Juan Francisco Rodríguez-Landa3Programa de Doctorado en Neuroetología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, VER, MexicoPrograma de Doctorado en Neuroetología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, VER, MexicoFacultad de Química Farmacéutica Biológica, Universidad Veracruzana, Xalapa, VER, MexicoFacultad de Química Farmacéutica Biológica, Universidad Veracruzana, Xalapa, VER, MexicoFlavonoids are phenolic compounds found commonly in plants that protect them against the negative effects of environmental insults. These secondary metabolites have been widely studied in preclinical research because of their biological effects, particularly as antioxidant agents. Diverse flavonoids have been studied to explore their potential therapeutic effects in the treatment of disorders of the central nervous system, including anxiety and depression. The present review discusses advances in the study of some flavonoids as potential antidepressant agents. We describe their behavioral, physiological, and neurochemical effects and the apparent mechanism of action of their preclinical antidepressant-like effects. Natural flavonoids produce antidepressant-like effects in validated behavioral models of depression. The mechanism of action of these effects includes the activation of serotonergic, dopaminergic, noradrenergic, and γ-aminobutyric acid-ergic neurotransmitter systems and an increase in the production of neural factors, including brain-derived neurotrophic factor and nerve growth factor. Additionally, alterations in the function of tropomyosin receptor kinase B and activity of the enzyme monoamine oxidase A have been reported. In conclusion, preclinical research supports the potential antidepressant effects of some natural flavonoids, which opens new possibilities of evaluating these substances to develop complementary therapeutic alternatives that could ameliorate symptoms of depressive disorders in humans.http://dx.doi.org/10.1155/2018/2963565 |
| spellingShingle | León Jesús German-Ponciano Gilberto Uriel Rosas-Sánchez Eduardo Rivadeneyra-Domínguez Juan Francisco Rodríguez-Landa Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant Agents Scientifica |
| title | Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant Agents |
| title_full | Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant Agents |
| title_fullStr | Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant Agents |
| title_full_unstemmed | Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant Agents |
| title_short | Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant Agents |
| title_sort | advances in the preclinical study of some flavonoids as potential antidepressant agents |
| url | http://dx.doi.org/10.1155/2018/2963565 |
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