Blood Eosinophil Count in Asthma Is Associated With Increased Abdominal Aortic Diameter and Increased Vascular Stiffness
Leonie Biener,* Andrea Budimovska,* Dirk Skowasch, Carmen Pizarro, Ben Christoph Frisch, Georg Nickenig, Max Jonathan Stumpf, Christian A Schaefer,* Nadjib Schahab* Department of Internal Medicine II - Cardiology, Pneumology and Angiology, University of Bonn, Bonn, Ge...
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Dove Medical Press
2025-02-01
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| author | Biener L Budimovska A Skowasch D Pizarro C Frisch BC Nickenig G Stumpf MJ Schaefer CA Schahab N |
| author_facet | Biener L Budimovska A Skowasch D Pizarro C Frisch BC Nickenig G Stumpf MJ Schaefer CA Schahab N |
| author_sort | Biener L |
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| description | Leonie Biener,* Andrea Budimovska,* Dirk Skowasch, Carmen Pizarro, Ben Christoph Frisch, Georg Nickenig, Max Jonathan Stumpf, Christian A Schaefer,* Nadjib Schahab* Department of Internal Medicine II - Cardiology, Pneumology and Angiology, University of Bonn, Bonn, Germany*These authors contributed equally to this workCorrespondence: Leonie Biener, Department of Internal Medicine II - Cardiology, Pneumology and Angiology, University of Bonn, Venusberg Campus 1, Bonn, 53127, Germany, Email Leonie.Biener@ukbonn.deBackground: Asthma is associated with atherosclerosis and abdominal aortic aneurysm (AAA). However, the underlying pathomechanisms remain elusive. Blood eosinophil count (BEC) is implicated in both eosinophilic asthma and arterial wall inflammation.Objective: To explore the possible association of BEC in asthma and abdominal aortic artery changes.Methods: 112 outpatients were prospectively enrolled in this exploratory study. Abdominal aortic diameter was measured using ultrasonography imaging, while vascular speckle tracking was utilized to evaluate vascular strains. Patients were stratified into two groups, with n=66 patients with a BEC of ≥ 300 n/μL and n=46 patients with < 300 n/μL. Both groups exhibited no significant disparities in cardiovascular risk factors; however, the high BEC group was more frequently male.Results: The aortic diameter was wider in patients with a BEC ≥ 300 n/μL (1.46 ± 0.25 cm vs 1.67 ± 0.63 cm, p=0.018). Three patients were diagnosed with an AAA, all had a BEC ≥ 300 n/μL. Patients with a BEC ≥ 300 n/μL exhibited lower strain values, indicative of higher vascular stiffness, including radial strain (2.65 ± 1.38% vs 4.46 ± 2.59%; p< 0.001). BEC exhibited a positive correlation with abdominal aortic diameter (R²=0.131, b=0.000, p< 0.001), and a negative correlation with radial strain values (R²=0.131, b=− 0.002, p=0.001) in sex-adjusted linear regression.Conclusion: In patients with asthma, blood eosinophil count (BEC) is correlated with a wider aortic diameter and heightened vascular stiffness in the abdominal aorta. Hence, they may be at an elevated risk of developing an AAA.Keywords: blood eosinophil count, asthma, abdominal aortic diameter, aneurysm, vascular stiffness |
| format | Article |
| id | doaj-art-c066cedf74ea4686a25bd7ccc4dcd207 |
| institution | OA Journals |
| issn | 1178-6965 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Dove Medical Press |
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| series | Journal of Asthma and Allergy |
| spelling | doaj-art-c066cedf74ea4686a25bd7ccc4dcd2072025-08-20T02:14:31ZengDove Medical PressJournal of Asthma and Allergy1178-69652025-02-01Volume 18245255100380Blood Eosinophil Count in Asthma Is Associated With Increased Abdominal Aortic Diameter and Increased Vascular StiffnessBiener LBudimovska ASkowasch DPizarro CFrisch BCNickenig GStumpf MJSchaefer CASchahab NLeonie Biener,* Andrea Budimovska,* Dirk Skowasch, Carmen Pizarro, Ben Christoph Frisch, Georg Nickenig, Max Jonathan Stumpf, Christian A Schaefer,* Nadjib Schahab* Department of Internal Medicine II - Cardiology, Pneumology and Angiology, University of Bonn, Bonn, Germany*These authors contributed equally to this workCorrespondence: Leonie Biener, Department of Internal Medicine II - Cardiology, Pneumology and Angiology, University of Bonn, Venusberg Campus 1, Bonn, 53127, Germany, Email Leonie.Biener@ukbonn.deBackground: Asthma is associated with atherosclerosis and abdominal aortic aneurysm (AAA). However, the underlying pathomechanisms remain elusive. Blood eosinophil count (BEC) is implicated in both eosinophilic asthma and arterial wall inflammation.Objective: To explore the possible association of BEC in asthma and abdominal aortic artery changes.Methods: 112 outpatients were prospectively enrolled in this exploratory study. Abdominal aortic diameter was measured using ultrasonography imaging, while vascular speckle tracking was utilized to evaluate vascular strains. Patients were stratified into two groups, with n=66 patients with a BEC of ≥ 300 n/μL and n=46 patients with < 300 n/μL. Both groups exhibited no significant disparities in cardiovascular risk factors; however, the high BEC group was more frequently male.Results: The aortic diameter was wider in patients with a BEC ≥ 300 n/μL (1.46 ± 0.25 cm vs 1.67 ± 0.63 cm, p=0.018). Three patients were diagnosed with an AAA, all had a BEC ≥ 300 n/μL. Patients with a BEC ≥ 300 n/μL exhibited lower strain values, indicative of higher vascular stiffness, including radial strain (2.65 ± 1.38% vs 4.46 ± 2.59%; p< 0.001). BEC exhibited a positive correlation with abdominal aortic diameter (R²=0.131, b=0.000, p< 0.001), and a negative correlation with radial strain values (R²=0.131, b=− 0.002, p=0.001) in sex-adjusted linear regression.Conclusion: In patients with asthma, blood eosinophil count (BEC) is correlated with a wider aortic diameter and heightened vascular stiffness in the abdominal aorta. Hence, they may be at an elevated risk of developing an AAA.Keywords: blood eosinophil count, asthma, abdominal aortic diameter, aneurysm, vascular stiffnesshttps://www.dovepress.com/blood-eosinophil-count-in-asthma-is-associated-with-increased-abdomina-peer-reviewed-fulltext-article-JAAblood eosinophil countasthmaabdominal aortic diameteraneurysmvascular stiffness |
| spellingShingle | Biener L Budimovska A Skowasch D Pizarro C Frisch BC Nickenig G Stumpf MJ Schaefer CA Schahab N Blood Eosinophil Count in Asthma Is Associated With Increased Abdominal Aortic Diameter and Increased Vascular Stiffness Journal of Asthma and Allergy blood eosinophil count asthma abdominal aortic diameter aneurysm vascular stiffness |
| title | Blood Eosinophil Count in Asthma Is Associated With Increased Abdominal Aortic Diameter and Increased Vascular Stiffness |
| title_full | Blood Eosinophil Count in Asthma Is Associated With Increased Abdominal Aortic Diameter and Increased Vascular Stiffness |
| title_fullStr | Blood Eosinophil Count in Asthma Is Associated With Increased Abdominal Aortic Diameter and Increased Vascular Stiffness |
| title_full_unstemmed | Blood Eosinophil Count in Asthma Is Associated With Increased Abdominal Aortic Diameter and Increased Vascular Stiffness |
| title_short | Blood Eosinophil Count in Asthma Is Associated With Increased Abdominal Aortic Diameter and Increased Vascular Stiffness |
| title_sort | blood eosinophil count in asthma is associated with increased abdominal aortic diameter and increased vascular stiffness |
| topic | blood eosinophil count asthma abdominal aortic diameter aneurysm vascular stiffness |
| url | https://www.dovepress.com/blood-eosinophil-count-in-asthma-is-associated-with-increased-abdomina-peer-reviewed-fulltext-article-JAA |
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