Evaluation of Associated Structural and Chromosomal Abnormalities in Patients with Fetal Cerebral Ventriculomegaly Detected in Ultrasonographic Imaging
OBJECTIVE: Fetal cerebral ventriculomegaly is defined as enlarged cerebral lateral ventricles. The etiology of fetal cerebral ventriculomegaly is multifactorial. Aneuploidy in ventriculomegaly is detected especially in moderate and severe ventriculomegaly accompanied by structural anomalies. This s...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Medical Network
2022-12-01
|
| Series: | Gynecology Obstetrics & Reproductive Medicine |
| Subjects: | |
| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/1287 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823857376673923072 |
|---|---|
| author | Erkan Cagliyan Samican Ozmen Sureyya Saridas Demir Ceren Aydin Egehan Bilen Handan Guleryuz Elif Yasar Derya Ercal Elcin Bora Tufan Cankaya |
| author_facet | Erkan Cagliyan Samican Ozmen Sureyya Saridas Demir Ceren Aydin Egehan Bilen Handan Guleryuz Elif Yasar Derya Ercal Elcin Bora Tufan Cankaya |
| author_sort | Erkan Cagliyan |
| collection | DOAJ |
| description |
OBJECTIVE: Fetal cerebral ventriculomegaly is defined as enlarged cerebral lateral ventricles. The etiology of fetal cerebral ventriculomegaly is multifactorial. Aneuploidy in ventriculomegaly is detected especially in moderate and severe ventriculomegaly accompanied by structural anomalies. This study aims to evaluate patients with fetal cerebral ventriculomegaly for associated structural and genetic abnormalities and their obstetric and neonatal outcomes.
STUDY DESIGN: This retrospective cohort study was conducted at Dokuz Eylul University Faculty of Medicine, Obstetrics and Gynecology Department between January 2009 and December 2019. Eighty-seven cases were included in the study and were evaluated for associated structural abnormalities. The results of genetic diagnostic tests were evaluated retrospectively. Postpartum information of the cases was obtained from the hospital records and neurodevelopmental development of the newborns was recorded.
RESULTS: Patients were classified as mild, moderate, and severe ventriculomegaly. Concomitant structural abnormalities were observed in 64% of the patients. Corpus callosum agenesis was the most common abnormality. The incidence of accompanying anomalies in severe ventriculomegaly was found to be significantly higher. Invasive prenatal tests were performed on 27 patients and one of them had a chromosomal abnormality. No significant correlation was observed between the incidence of postpartum neurodevelopmental disorders and the degrees of ventriculomegaly.
CONCLUSIONS: Fetal cerebral ventriculomegaly is a dynamic process. The etiology is multifactorial and abnormalities can be detected during follow-up. All patients should be evaluated carefully for associated abnormalities. The cases should also be evaluated for neurodevelopmental outcomes after birth. All diagnosis, follow-up, and treatment options should be handled with a multidisciplinary approach.
|
| format | Article |
| id | doaj-art-c066a8c725b248d7a28f9fb3ec10cb78 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-c066a8c725b248d7a28f9fb3ec10cb782025-02-11T21:16:15ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182022-12-0128310.21613/GORM.2022.1287Evaluation of Associated Structural and Chromosomal Abnormalities in Patients with Fetal Cerebral Ventriculomegaly Detected in Ultrasonographic ImagingErkan Cagliyan0Samican Ozmen1Sureyya Saridas Demir2Ceren Aydin3Egehan Bilen4Handan Guleryuz5Elif Yasar6Derya Ercal7Elcin Bora8Tufan Cankaya9Department of Gynecology and Obstetrics, Dokuz Eylul University School of Medicine, Izmir, TurkeyAssistant DoctorDepartment of Gynecology and Obstetrics, Dokuz Eylul University School of Medicine, Izmir, TurkeyDepartment of Gynecology and Obstetrics, Dokuz Eylul University School of Medicine, Izmir, TurkeyDepartment of Gynecology and Obstetrics, Dokuz Eylul University School of Medicine, Izmir, TurkeyDepartment of Radiology, Dokuz Eylul University School of Medicine, Izmir, TurkeyDepartment of Radiology, Dokuz Eylul University School of Medicine, Izmir, TurkeyDepartment of Medical Genetics Eylul University School of Medicine, Izmir, Turkey Department of Medical Genetics, Dokuz Eylul University School of Medicine, Izmir, TurkeyDepartment of Medical Genetics, Dokuz Eylul University School of Medicine, Izmir, Turkey OBJECTIVE: Fetal cerebral ventriculomegaly is defined as enlarged cerebral lateral ventricles. The etiology of fetal cerebral ventriculomegaly is multifactorial. Aneuploidy in ventriculomegaly is detected especially in moderate and severe ventriculomegaly accompanied by structural anomalies. This study aims to evaluate patients with fetal cerebral ventriculomegaly for associated structural and genetic abnormalities and their obstetric and neonatal outcomes. STUDY DESIGN: This retrospective cohort study was conducted at Dokuz Eylul University Faculty of Medicine, Obstetrics and Gynecology Department between January 2009 and December 2019. Eighty-seven cases were included in the study and were evaluated for associated structural abnormalities. The results of genetic diagnostic tests were evaluated retrospectively. Postpartum information of the cases was obtained from the hospital records and neurodevelopmental development of the newborns was recorded. RESULTS: Patients were classified as mild, moderate, and severe ventriculomegaly. Concomitant structural abnormalities were observed in 64% of the patients. Corpus callosum agenesis was the most common abnormality. The incidence of accompanying anomalies in severe ventriculomegaly was found to be significantly higher. Invasive prenatal tests were performed on 27 patients and one of them had a chromosomal abnormality. No significant correlation was observed between the incidence of postpartum neurodevelopmental disorders and the degrees of ventriculomegaly. CONCLUSIONS: Fetal cerebral ventriculomegaly is a dynamic process. The etiology is multifactorial and abnormalities can be detected during follow-up. All patients should be evaluated carefully for associated abnormalities. The cases should also be evaluated for neurodevelopmental outcomes after birth. All diagnosis, follow-up, and treatment options should be handled with a multidisciplinary approach. https://gorm.com.tr/index.php/GORM/article/view/1287Associated anomaliesFetal cerebral ventriculomegaly Prenatal diagnosis |
| spellingShingle | Erkan Cagliyan Samican Ozmen Sureyya Saridas Demir Ceren Aydin Egehan Bilen Handan Guleryuz Elif Yasar Derya Ercal Elcin Bora Tufan Cankaya Evaluation of Associated Structural and Chromosomal Abnormalities in Patients with Fetal Cerebral Ventriculomegaly Detected in Ultrasonographic Imaging Gynecology Obstetrics & Reproductive Medicine Associated anomalies Fetal cerebral ventriculomegaly Prenatal diagnosis |
| title | Evaluation of Associated Structural and Chromosomal Abnormalities in Patients with Fetal Cerebral Ventriculomegaly Detected in Ultrasonographic Imaging |
| title_full | Evaluation of Associated Structural and Chromosomal Abnormalities in Patients with Fetal Cerebral Ventriculomegaly Detected in Ultrasonographic Imaging |
| title_fullStr | Evaluation of Associated Structural and Chromosomal Abnormalities in Patients with Fetal Cerebral Ventriculomegaly Detected in Ultrasonographic Imaging |
| title_full_unstemmed | Evaluation of Associated Structural and Chromosomal Abnormalities in Patients with Fetal Cerebral Ventriculomegaly Detected in Ultrasonographic Imaging |
| title_short | Evaluation of Associated Structural and Chromosomal Abnormalities in Patients with Fetal Cerebral Ventriculomegaly Detected in Ultrasonographic Imaging |
| title_sort | evaluation of associated structural and chromosomal abnormalities in patients with fetal cerebral ventriculomegaly detected in ultrasonographic imaging |
| topic | Associated anomalies Fetal cerebral ventriculomegaly Prenatal diagnosis |
| url | https://gorm.com.tr/index.php/GORM/article/view/1287 |
| work_keys_str_mv | AT erkancagliyan evaluationofassociatedstructuralandchromosomalabnormalitiesinpatientswithfetalcerebralventriculomegalydetectedinultrasonographicimaging AT samicanozmen evaluationofassociatedstructuralandchromosomalabnormalitiesinpatientswithfetalcerebralventriculomegalydetectedinultrasonographicimaging AT sureyyasaridasdemir evaluationofassociatedstructuralandchromosomalabnormalitiesinpatientswithfetalcerebralventriculomegalydetectedinultrasonographicimaging AT cerenaydin evaluationofassociatedstructuralandchromosomalabnormalitiesinpatientswithfetalcerebralventriculomegalydetectedinultrasonographicimaging AT egehanbilen evaluationofassociatedstructuralandchromosomalabnormalitiesinpatientswithfetalcerebralventriculomegalydetectedinultrasonographicimaging AT handanguleryuz evaluationofassociatedstructuralandchromosomalabnormalitiesinpatientswithfetalcerebralventriculomegalydetectedinultrasonographicimaging AT elifyasar evaluationofassociatedstructuralandchromosomalabnormalitiesinpatientswithfetalcerebralventriculomegalydetectedinultrasonographicimaging AT deryaercal evaluationofassociatedstructuralandchromosomalabnormalitiesinpatientswithfetalcerebralventriculomegalydetectedinultrasonographicimaging AT elcinbora evaluationofassociatedstructuralandchromosomalabnormalitiesinpatientswithfetalcerebralventriculomegalydetectedinultrasonographicimaging AT tufancankaya evaluationofassociatedstructuralandchromosomalabnormalitiesinpatientswithfetalcerebralventriculomegalydetectedinultrasonographicimaging |