Role of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation
Vascular inflammation plays a crucial role in atherosclerosis, and its regulation is important to prevent cerebrovascular and coronary artery disease. The inflammatory process in atherogenesis involves a variety of immune cells including monocytes/macrophages, lymphocytes, dendritic cells, and neutr...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/508416 |
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| author | Kousei Ohshima Masaki Mogi Masatsugu Horiuchi |
| author_facet | Kousei Ohshima Masaki Mogi Masatsugu Horiuchi |
| author_sort | Kousei Ohshima |
| collection | DOAJ |
| description | Vascular inflammation plays a crucial role in atherosclerosis, and its regulation is important to prevent cerebrovascular and coronary artery disease. The inflammatory process in atherogenesis involves a variety of immune cells including monocytes/macrophages, lymphocytes, dendritic cells, and neutrophils, which all express peroxisome proliferator-activated receptor-γ (PPAR-γ). PPAR-γ is a nuclear receptor and transcription factor in the steroid superfamily and is known to be a key regulator of adipocyte differentiation. Increasing evidence from mainly experimental studies has demonstrated that PPAR-γ activation by endogenous and synthetic ligands is involved in lipid metabolism and anti-inflammatory activity. In addition, recent clinical studies have shown a beneficial effect of thiazolidinediones, synthetic PPAR-γ ligands, on cardiovascular disease beyond glycemic control. These results suggest that PPAR-γ activation is an important regulator in vascular inflammation and is expected to be a therapeutic target in the treatment of atherosclerotic complications. This paper reviews the recent findings of PPAR-γ involvement in vascular inflammation and the therapeutic potential of regulating the immune system in atherosclerosis. |
| format | Article |
| id | doaj-art-c05552fa5db6423988f14999deebe136 |
| institution | OA Journals |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-c05552fa5db6423988f14999deebe1362025-08-20T02:19:26ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322012-01-01201210.1155/2012/508416508416Role of Peroxisome Proliferator-Activated Receptor-γ in Vascular InflammationKousei Ohshima0Masaki Mogi1Masatsugu Horiuchi2Department of Molecular Cardiovascular Biology and Pharmacology, Graduate School of Medicine, Ehime University, Shitsukawa, Ehime, Toon 791-0295, JapanDepartment of Molecular Cardiovascular Biology and Pharmacology, Graduate School of Medicine, Ehime University, Shitsukawa, Ehime, Toon 791-0295, JapanDepartment of Molecular Cardiovascular Biology and Pharmacology, Graduate School of Medicine, Ehime University, Shitsukawa, Ehime, Toon 791-0295, JapanVascular inflammation plays a crucial role in atherosclerosis, and its regulation is important to prevent cerebrovascular and coronary artery disease. The inflammatory process in atherogenesis involves a variety of immune cells including monocytes/macrophages, lymphocytes, dendritic cells, and neutrophils, which all express peroxisome proliferator-activated receptor-γ (PPAR-γ). PPAR-γ is a nuclear receptor and transcription factor in the steroid superfamily and is known to be a key regulator of adipocyte differentiation. Increasing evidence from mainly experimental studies has demonstrated that PPAR-γ activation by endogenous and synthetic ligands is involved in lipid metabolism and anti-inflammatory activity. In addition, recent clinical studies have shown a beneficial effect of thiazolidinediones, synthetic PPAR-γ ligands, on cardiovascular disease beyond glycemic control. These results suggest that PPAR-γ activation is an important regulator in vascular inflammation and is expected to be a therapeutic target in the treatment of atherosclerotic complications. This paper reviews the recent findings of PPAR-γ involvement in vascular inflammation and the therapeutic potential of regulating the immune system in atherosclerosis.http://dx.doi.org/10.1155/2012/508416 |
| spellingShingle | Kousei Ohshima Masaki Mogi Masatsugu Horiuchi Role of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation International Journal of Vascular Medicine |
| title | Role of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation |
| title_full | Role of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation |
| title_fullStr | Role of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation |
| title_full_unstemmed | Role of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation |
| title_short | Role of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation |
| title_sort | role of peroxisome proliferator activated receptor γ in vascular inflammation |
| url | http://dx.doi.org/10.1155/2012/508416 |
| work_keys_str_mv | AT kouseiohshima roleofperoxisomeproliferatoractivatedreceptorginvascularinflammation AT masakimogi roleofperoxisomeproliferatoractivatedreceptorginvascularinflammation AT masatsuguhoriuchi roleofperoxisomeproliferatoractivatedreceptorginvascularinflammation |