The Levels of Adhesion Molecules in Essential Thrombocythemia
Background: It is known that thrombocytosis is closely related to vascular complications and particularly thrombosis in essential thrombocytemia (ET) cases. The aim of this study is to investigate a possible correlation between adhesion molecules and vascular attacks as well as the relation of these...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2014-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1738 |
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| author | Oktay Bilgir Ferda Bilgir Mehmet Calan Ferlt Sari |
| author_facet | Oktay Bilgir Ferda Bilgir Mehmet Calan Ferlt Sari |
| author_sort | Oktay Bilgir |
| collection | DOAJ |
| description | Background: It is known that thrombocytosis is closely related to vascular complications and particularly thrombosis in essential thrombocytemia (ET) cases. The aim of this study is to investigate a possible correlation between adhesion molecules and vascular attacks as well as the relation of these molecules to the platelet count.
Material and Methods: The study group consisted of 30 essential thrombocythemia patients and 30 healthy controls subjects. Serum intracellular adhesion molecule-1 (ICAM-1), serum vascular adhesion molecule-1 (VCAM-1) and serum E-selectin levels were determined by ELISA method according to manufacturer’s instructions.
Results: There were no significant differences between two groups with respect to levels of sICAM-1 and sE-selectin (p>0.05). The VCAM-1 levels and platelets were significantly higher in patients with ET compared to controls (p=0.000). Spearman’s correlation analysis revealed that sVCAM-1 levels were correlated with platelet counts (r=0.574, p<0.001)
Conclusions: High VCAM-1 level in Essential Thrombocytosis and its correlation with the platelet count suggest that these may be a factor in vascular complications and thrombocytosis. |
| format | Article |
| id | doaj-art-c0539d74a3ec4902bade97a66a1ab33d |
| institution | OA Journals |
| issn | 2035-3006 |
| language | English |
| publishDate | 2014-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-c0539d74a3ec4902bade97a66a1ab33d2025-08-20T02:08:32ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062014-08-011The Levels of Adhesion Molecules in Essential ThrombocythemiaOktay Bilgir0Ferda Bilgir1Mehmet Calan2Ferlt Sari3Izmir Bozyaka Research and Training Hospital Department of Hematology Bozyaka/Izmir/TurkeyCelal Bayar University Medical School Department of allergy and immunology Manisa/TurkeyDokuz Eylul University Medical School Department of endocrinology and Metabolism Izmir/TurkeyIzmir Bozyaka Research and Training Hospital Department of Hematology Bozyaka/Izmir/TurkeyBackground: It is known that thrombocytosis is closely related to vascular complications and particularly thrombosis in essential thrombocytemia (ET) cases. The aim of this study is to investigate a possible correlation between adhesion molecules and vascular attacks as well as the relation of these molecules to the platelet count. Material and Methods: The study group consisted of 30 essential thrombocythemia patients and 30 healthy controls subjects. Serum intracellular adhesion molecule-1 (ICAM-1), serum vascular adhesion molecule-1 (VCAM-1) and serum E-selectin levels were determined by ELISA method according to manufacturer’s instructions. Results: There were no significant differences between two groups with respect to levels of sICAM-1 and sE-selectin (p>0.05). The VCAM-1 levels and platelets were significantly higher in patients with ET compared to controls (p=0.000). Spearman’s correlation analysis revealed that sVCAM-1 levels were correlated with platelet counts (r=0.574, p<0.001) Conclusions: High VCAM-1 level in Essential Thrombocytosis and its correlation with the platelet count suggest that these may be a factor in vascular complications and thrombocytosis.https://mjhid.org/index.php/mjhid/article/view/1738Essential ThrombocythemiaICAMVCAME-selectinplatelet count |
| spellingShingle | Oktay Bilgir Ferda Bilgir Mehmet Calan Ferlt Sari The Levels of Adhesion Molecules in Essential Thrombocythemia Mediterranean Journal of Hematology and Infectious Diseases Essential Thrombocythemia ICAM VCAM E-selectin platelet count |
| title | The Levels of Adhesion Molecules in Essential Thrombocythemia |
| title_full | The Levels of Adhesion Molecules in Essential Thrombocythemia |
| title_fullStr | The Levels of Adhesion Molecules in Essential Thrombocythemia |
| title_full_unstemmed | The Levels of Adhesion Molecules in Essential Thrombocythemia |
| title_short | The Levels of Adhesion Molecules in Essential Thrombocythemia |
| title_sort | levels of adhesion molecules in essential thrombocythemia |
| topic | Essential Thrombocythemia ICAM VCAM E-selectin platelet count |
| url | https://mjhid.org/index.php/mjhid/article/view/1738 |
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